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Association between the polymorphism of C861G (rs6296) in the serotonin 1B receptor gene and Tourette syndrome in Han Chinese people

Association between the polymorphism of C861G (rs6296) in the serotonin 1B receptor gene and... IntroductionTourette syndrome (TS) is a childhood onset neuropsychiatric movement disorder characterized by multiple motor tics and one or more vocal/phonic tics, lasting longer than a year. To date, the prevalence range of TS is between 0.4% to 3.8% of youngsters between the ages of 5 and 18 years (Robertson, ). The onset age of TS being reported is between the ages of 4 and 6 years and reach their worst‐ever severity between the ages of 10 and 12 years (Bloch and Leckman, ). Boys/men are more commonly affected, with the male : female ratio being about 3∼4:1. About 88% of individuals had been reported comorbidity, psychopathology and other difficulties (Freeman et al., ). The predominant comorbid disorders in TS include attention deficit hyperactivity disorder (ADHD), obsessive–compulsive behavior (OCB) and obsessive–compulsive disorder (OCD), while the most common coexisting psychopathologies are depression, learning difficulties and so on (Robertson, ). These disorders often causemore problems for the children both at home and at school than do tics alone.Although the pathogenesis of TS is not specific, the family and twin studies certified that TS is a genetic disease (Deng et al., ). The etiology of TS is the complex interaction of environmental adversities and genetic background (Hoekstra http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Asia-Pacific Psychiatry Wiley

Association between the polymorphism of C861G (rs6296) in the serotonin 1B receptor gene and Tourette syndrome in Han Chinese people

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References (36)

Publisher
Wiley
Copyright
© 2017 John Wiley & Sons Australia, Ltd
ISSN
1758-5864
eISSN
1758-5872
DOI
10.1111/appy.12196
pmid
26123080
Publisher site
See Article on Publisher Site

Abstract

IntroductionTourette syndrome (TS) is a childhood onset neuropsychiatric movement disorder characterized by multiple motor tics and one or more vocal/phonic tics, lasting longer than a year. To date, the prevalence range of TS is between 0.4% to 3.8% of youngsters between the ages of 5 and 18 years (Robertson, ). The onset age of TS being reported is between the ages of 4 and 6 years and reach their worst‐ever severity between the ages of 10 and 12 years (Bloch and Leckman, ). Boys/men are more commonly affected, with the male : female ratio being about 3∼4:1. About 88% of individuals had been reported comorbidity, psychopathology and other difficulties (Freeman et al., ). The predominant comorbid disorders in TS include attention deficit hyperactivity disorder (ADHD), obsessive–compulsive behavior (OCB) and obsessive–compulsive disorder (OCD), while the most common coexisting psychopathologies are depression, learning difficulties and so on (Robertson, ). These disorders often causemore problems for the children both at home and at school than do tics alone.Although the pathogenesis of TS is not specific, the family and twin studies certified that TS is a genetic disease (Deng et al., ). The etiology of TS is the complex interaction of environmental adversities and genetic background (Hoekstra

Journal

Asia-Pacific PsychiatryWiley

Published: Jun 1, 2017

Keywords: ; ; ; ;

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