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Association between the MDR1 gene variant C3435T and risk of leukaemia: a meta‐analysis

Association between the MDR1 gene variant C3435T and risk of leukaemia: a meta‐analysis Although a number of genetic studies have attempted to link the multidrug resistance (MDR1) C3435T polymorphism to risk of leukaemia, the results were often inconsistent. The present study aimed at investigating the pooled association using a meta‐analysis on the published studies. 1933 cases and 2215 controls of 11 published studies in English before June 2012 were involved in the updated meta‐analysis. Furthermore, subgroup analysis was performed in different ethnic and leukaemia subtype groups. This meta‐analysis suggests that the MDR1 C3435T polymorphism associate with risk of leukaemia. The effect of the variant on the expression levels and the possible functional role of the variant in leukaemia should be addressed in further studies. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Cancer Care Wiley

Association between the MDR1 gene variant C3435T and risk of leukaemia: a meta‐analysis

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References (55)

Publisher
Wiley
Copyright
Copyright © 2013 John Wiley & Sons Ltd
ISSN
0961-5423
eISSN
1365-2354
DOI
10.1111/ecc.12067
pmid
23731124
Publisher site
See Article on Publisher Site

Abstract

Although a number of genetic studies have attempted to link the multidrug resistance (MDR1) C3435T polymorphism to risk of leukaemia, the results were often inconsistent. The present study aimed at investigating the pooled association using a meta‐analysis on the published studies. 1933 cases and 2215 controls of 11 published studies in English before June 2012 were involved in the updated meta‐analysis. Furthermore, subgroup analysis was performed in different ethnic and leukaemia subtype groups. This meta‐analysis suggests that the MDR1 C3435T polymorphism associate with risk of leukaemia. The effect of the variant on the expression levels and the possible functional role of the variant in leukaemia should be addressed in further studies.

Journal

European Journal of Cancer CareWiley

Published: Jan 1, 2013

Keywords: ; ; ;

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