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R. Kim, B. Leake, E. Choo, G. Dresser, Samir Kubba, U. Schwarz, A. Taylor, H. Xie, J. McKinsey, Sheng Zhou, Lu-bin Lan, J. Schuetz, E. Schuetz, G. Wilkinson (2001)
Identification of functionally variant MDR1 alleles among European Americans and African AmericansClinical Pharmacology & Therapeutics, 70
Humeny (2003)
2735Anticancer Research, 23
Rao (2010)
1063Asian Pacific Journal of Cancer Prevention: APJCP, 11
Dean (2001)
1156Genome Research, 11
G. Penna, A. Allegra, A. Alonci, Mohamed Aguennouz, Alessia Garufi, A. Cannavó, D. Gerace, Angela Alibrandi, C. Musolino (2011)
MDR-1 polymorphisms (G2677T and C3435T) in B-chronic lymphocytic leukemia: an impact on susceptibility and prognosisMedical Oncology, 28
Drach (1996)
1747Blood, 88
M. Čižmáriková, M. Wagnerová, L. Schonova, V. Habalová, A. Kohút, A. Linková, M. Šarišský, J. Mojžiš, L. Mirossay, A. Miroššay (2010)
MDR1 (C3435T) polymorphism: relation to the risk of breast cancer and therapeutic outcomeThe Pharmacogenomics Journal, 10
K. Ueda, C. Cardarelli, M. Gottesman, I. Pastan (1987)
Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine.Proceedings of the National Academy of Sciences of the United States of America, 84 9
K. Urayama, J. Wiencke, P. Buffler, A. Chokkalingam, C. Metayer, J. Wiemels (2007)
MDR1 Gene Variants, Indoor Insecticide Exposure, and the Risk of Childhood Acute Lymphoblastic LeukemiaCancer Epidemiology Biomarkers & Prevention, 16
Maria Bernardo, Dalemari Crowther-Swanepoel, P. Broderick, E. Webb, G. Sellick, R. Wild, K. Sullivan, J. Vijayakrishnan, Yufei Wang, A. Pittman, N. Sunter, A. Hall, M. Dyer, E. Matutes, C. Dearden, T. Mainou-fowler, G. Jackson, G. Summerfield, Robert Harris, A. Pettitt, P. Hillmen, D. Allsup, J. Bailey, G. Pratt, C. Pepper, C. Fegan, J. Allan, D. Catovsky, R. Houlston (2008)
A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemiaNature Genetics, 40
W. Dalton (2007)
Faculty Opinions recommendation of A "silent" polymorphism in the MDR1 gene changes substrate specificity.
Chao Xuan, Xiao-yan Bai, G. Gao, Qin Yang, G. He (2011)
Association between polymorphism of methylenetetrahydrofolate reductase (MTHFR) C677T and risk of myocardial infarction: a meta-analysis for 8,140 cases and 10,522 controls.Archives of medical research, 42 8
C. Kimchi‐Sarfaty, J.M. Oh, I.W. Kim, Z.E. Sauna, A.M. Calcagno, S.V. Ambudkar, M.M. Gottesman (2007)
A ‘silent’ polymorphism in the MDR1 gene changes substrate specificityScience, 315
S. Hoffmeyer, O. Burk, O. Richter, H. Arnold, J. Brockmöller, A. Johne, I. Cascorbi, T. Gerloff, I. Roots, M. Eichelbaum, U. Brinkmann (2000)
Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo.Proceedings of the National Academy of Sciences of the United States of America, 97 7
J. Elliott, S. Raguz, C. Higgins (2004)
Multidrug transporter activity in lymphocytesBritish Journal of Pharmacology, 143
Rao Dn, C. Anuradha, S. Vishnupriya, K. Sailaja, D. Surekha, D. Raghunadharao, S. Rajappa (2010)
Association of an MDR1 gene (C3435T) polymorphism with acute leukemia in India.Asian Pacific journal of cancer prevention : APJCP, 11 4
K. Jamroziak, W. Młynarski, E. Balcerczak, Magda Mistygacz, J. Trelińska, M. Mirowski, J. Bodalski, T. Robak (2004)
Functional C3435T polymorphism of MDR1 gene: an impact on genetic susceptibility and clinical outcome of childhood acute lymphoblastic leukemiaEuropean Journal of Haematology, 72
Sudhir Gupta, Choong Kim, T. Tsuruo, S. Gollapudi (1992)
Preferential expression and activity of multidrug resistance gene 1 product (P-glycoprotein), a functionally active efflux pump, in human CD8 + T cells: A role in cytotoxic effector functionJournal of Clinical Immunology, 12
D. Parkin, C. Stiller, G. Draper, C. Bieber, B. Terracini, J. Young (1988)
The international incidence of childhood cancerInternational Journal of Cancer, 42
P. Chaudhary, I. Roninson (1991)
Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cellsCell, 66
D. Callen, E. Baker, R. Simmers, R. Seshadri, I. Roninson (1987)
Localization of the human multiple drug resistance gene, MDR1, to 7q21.1Human Genetics, 77
Azam Khedri, Amireh Nejat-Shokouhi, R. Salek, H. Esmaeili, A. Mokhtarifar, R. Heravi, F. Tatari, J. Behravan, B. Miladpour, Shahireh Tehrani (2011)
Association of the colorectal cancer and MDR1 gene polymorphism in an Iranian populationMolecular Biology Reports, 38
Songjian Chen, X. Huo, Yi Lin, Hao Ban, Yin-Cheng Lin, Weiqiu Li, Bao Zhang, W. Au, Xijin Xu (2010)
Association of MDR1 and ERCC1 polymorphisms with response and toxicity to cisplatin-based chemotherapy in non-small-cell lung cancer patients.International journal of hygiene and environmental health, 213 2
K. Fung, M. Gottesman (2009)
A synonymous polymorphism in a common MDR1 (ABCB1) haplotype shapes protein function.Biochimica et biophysica acta, 1794 5
M. Dean, A. Rzhetsky, R. Allikmets (2001)
The human ATP-binding cassette (ABC) transporter superfamily.Genome research, 11 7
Y. Uwai, S. Masuda, Maki Goto, Hideyuki Motohashi, H. Saito, M. Okuda, E. Nakamura, N. Ito, O. Ogawa, K. Inui (2004)
Common single nucleotide polymorphisms of the MDR1 gene have no influence on its mRNA expression level of normal kidney cortex and renal cell carcinoma in Japanese nephrectomized patientsJournal of Human Genetics, 49
Zhigui Ma, S. Morris, V. Valentine, Martin L, J. Herbrick, Xiaoli Cui, D. Bouman, Yue Li, Perdeep Mehta, D. Nižetić, Y. Kaneko, G. Chan, L. Chan, J. Squire, S. Scherer, J. Hitzler (2001)
Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemiaNature Genetics, 28
M. Hitzl, S. Drescher, H. Kuip, E. Schäffeler, J. Fischer, M. Schwab, M. Eichelbaum, M. Fromm (2001)
The C3435T mutation in the human MDR1 gene is associated with altered efflux of the P-glycoprotein substrate rhodamine 123 from CD56+ natural killer cells.Pharmacogenetics, 11 4
K. Jamroziak, E. Balcerczak, P. Smolewski, R. Robey, B. Cebula, M. Panczyk, M. Kowalczyk, A. Szmigielska-Kaplon, M. Mirowski, S. Bates, T. Robak (2006)
MDR1 (ABCB1) gene polymorphism C3435T is associated with P-glycoprotein activity in B-cell chronic lymphocytic leukemia.Pharmacological reports : PR, 58 5
Lingna Ni, Jian-yong Li, K. Miao, C. Qiao, Su-jiang Zhang, H. Qiu, S. Qian (2011)
Multidrug resistance gene (MDR1) polymorphisms correlate with imatinib response in chronic myeloid leukemiaMedical Oncology, 28
Chao Xuan, Limin Lun, Jin-Xia Zhao, Hong-wei Wang, B. Zhu, Shui Yu, Zhen Liu, Guo-Wei He (2013)
PTPN22 Gene Polymorphism (C1858T) Is Associated with Susceptibility to Type 1 Diabetes: A Meta‐Analysis of 19,495 Cases and 25,341 ControlsAnnals of Human Genetics, 77
Henrik Gréen, I. Falk, K. Lotfi, Esbjorn Paul, M. Hermansson, Richard Rosenquist, Richard Rosenquist, C. Paul, H. Nahi (2010)
Association of ABCB1 polymorphisms with survival and in vitro cytotoxicty in de novo acute myeloid leukemia with normal karyotypeThe Pharmacogenomics Journal, 12
Eun-Hye Hur, Je-Hwan Lee, M. Lee, Seong-jun Choi, Jung-Hee Lee, M. Kang, M. Seol, Y. Jang, Hee-Jung Lee, I. Kang, S. Shim, Seong-Gil Ryu, Y. Kang, Young-Shin Lee, Chan-Jeoung Park, H. Chi, K. Lee (2008)
C3435T polymorphism of the MDR1 gene is not associated with P-glycoprotein function of leukemic blasts and clinical outcome in patients with acute myeloid leukemia.Leukemia research, 32 10
Ágnes Semsei, D. Erdélyi, I. Ungvári, E. Kámory, B. Csókay, H. Andrikovics, A. Tordai, E. Cságoly, A. Falus, G. Kovács, C. Szalai (2008)
Association of some rare haplotypes and genotype combinations in the MDR1 gene with childhood acute lymphoblastic leukaemia.Leukemia research, 32 8
S. Haenisch, U. Zimmermann, E. Dazert, C. Wruck, P. Dazert, S. Siegmund, H. Kroemer, R. Warzok, I. Cascorbi (2007)
Influence of polymorphisms of ABCB1 and ABCC2 on mRNA and protein expression in normal and cancerous kidney cortexThe Pharmacogenomics Journal, 7
Q. Yan, N. Wajapeyee (2010)
Exploiting cellular senescence to treat cancer and circumvent drug resistanceCancer Biology & Therapy, 9
L. Henríquez-Hernández, A. Murias-Rosales, A. González-Hernández, A. León, Nicolás Díaz-Chico, L. Fernández-Pérez (2010)
Distribution of TYMS, MTHFR, p53 and MDR1 gene polymorphisms in patients with breast cancer treated with neoadjuvant chemotherapy.Cancer epidemiology, 34 5
Han-chun Chen, Wei-xin Hu, Qing-xia Liu, Wenfeng Li, Fang-zhi Chen, Zhou-zhou Rao, Xin-fa Liu, Ya-ping Luo, Yan-fei Cao (2008)
Genetic polymorphisms of metabolic enzymes CYP1A1, CYP2D6, GSTM1 and GSTT1 and leukemia susceptibilityEuropean Journal of Cancer Prevention, 17
H. Hattori, A. Suminoe, M. Wada, Yuhki Koga, K. Kohno, J. Okamura, T. Hara, A. Matsuzaki (2007)
Regulatory polymorphisms of multidrug resistance 1 (MDR1) gene are associated with the development of childhood acute lymphoblastic leukemia.Leukemia research, 31 12
M. Nauck, U. Stein, Sabine Karger, Winfried März, H. Wieland (2000)
Rapid detection of the C3435T polymorphism of multidrug resistance gene 1 using fluorogenic hybridization probes.Clinical chemistry, 46 12
E. Leal-Ugarte, M. Gutiérrez-Angulo, N. Macías-Gómez, V. Peralta-Leal, J. Durán-González, M. Ayala-Madrigal, M. Partida-Pérez, P. Barros-Núñez, D. Ruiz-Diaz, J. Moreno-Ortiz, J. Peregrina-Sandoval, J. Meza-Espinoza (2008)
MDR1 C3435T Polymorphism in Mexican Children with Acute Lymphoblastic Leukemia and in Healthy Individuals, 80
T. Reynolds (1998)
Researchers hunt for elusive environmental causes of leukemia.Journal of the National Cancer Institute, 90 2
Kimchi-Sarfaty (2007)
525Science, 315
J. Drach, A. Gsur, G. Hamilton, Shourong Zhao, J. Angerler, Michael Fiegl, N. Zojer, M. Raderer, I. Haberl, M. Andreeff, H. Huber (1996)
Involvement of P-glycoprotein in the transmembrane transport of interleukin-2 (IL-2), IL-4, and interferon-gamma in normal human T lymphocytes.Blood, 88 5
K. Jamroziak, E. Balcerczak, B. Cebula, A. Janus, M. Mirowski, T. Robak (2006)
No Influence of 3435C>T ABCB1 (MDR1) Gene Polymorphism on Risk of Adult Acute Myeloid Leukemia and P-glycoprotein Expression in Blast CellsTherapeutic Drug Monitoring, 28
Xifeng Qian, Songyu Cao, Guohua Yang, Jingyan Dong, G. Jin, Yunfeng Shen, Zhibin Hu (2012)
Variant genotypes of MDR1 C3435T increase the risk of leukemia: evidence from 10 case–control studiesLeukemia & Lymphoma, 53
Danxin Wang, Andrew Johnson, A. Papp, D. Kroetz, W. Sadee (2005)
Multidrug resistance polypeptide 1 (MDR1, ABCB1) variant 3435C>T affects mRNA stabilityPharmacogenetics and Genomics, 15
Chao Xuan, Bei-bei Zhang, Tao Yang, Kai-feng Deng, Ming Li, Ruifang Tian (2011)
Association between OCTN1/2 gene polymorphisms (1672C-T, 207G-C) and susceptibility of Crohn's disease: a meta-analysisInternational Journal of Colorectal Disease, 27
Jamroziak (2006b)
720Pharmacological Reports: PR, 58
L. Henríquez-Hernández, A. Murias-Rosales, A. González, A. León, B. Díaz-Chico, M. Santiago, L. Pérez (2009)
Gene polymorphisms in TYMS, MTHFR, p53 and MDR1 as risk factors for breast cancer: a case-control study.Oncology reports, 22 6
A. Humeny, F. Rödel, Claus Rödel, Rolf Sauer, László Füzesi, Cord-Michael Becker, Thomas Efferth (2003)
MDR1 single nucleotide polymorphism C3435T in normal colorectal tissue and colorectal carcinomas detected by MALDI-TOF mass spectrometry.Anticancer research, 23 3B
A. Komar (2007)
Silent SNPs: impact on gene function and phenotype.Pharmacogenomics, 8 8
D. Vivona, C. Bueno, L. Lima, R. Hirata, M. Hirata, A. Luchessi, M. Zanichelli, C. Chiattone, E. Guerra-Shinohara (2012)
ABCB1 haplotype is associated with major molecular response in chronic myeloid leukemia patients treated with standard-dose of imatinib.Blood cells, molecules & diseases, 48 2
Chao Xuan, Bei-bei Zhang, Ming Li, Kai-feng Deng, Tao Yang, Xiang-e Zhang (2011)
No association between APOE epsilon 4 allele and multiple sclerosis susceptibility: A meta-analysis from 5472 cases and 4727 controlsJournal of the Neurological Sciences, 308
L. Shen, J. Basilion, V. Stanton (1999)
Single-nucleotide polymorphisms can cause different structural folds of mRNA.Proceedings of the National Academy of Sciences of the United States of America, 96 14
Although a number of genetic studies have attempted to link the multidrug resistance (MDR1) C3435T polymorphism to risk of leukaemia, the results were often inconsistent. The present study aimed at investigating the pooled association using a meta‐analysis on the published studies. 1933 cases and 2215 controls of 11 published studies in English before June 2012 were involved in the updated meta‐analysis. Furthermore, subgroup analysis was performed in different ethnic and leukaemia subtype groups. This meta‐analysis suggests that the MDR1 C3435T polymorphism associate with risk of leukaemia. The effect of the variant on the expression levels and the possible functional role of the variant in leukaemia should be addressed in further studies.
European Journal of Cancer Care – Wiley
Published: Jan 1, 2013
Keywords: ; ; ;
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