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- Publisher
- Wiley
- Copyright
- Copyright © 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim
- ISSN
- 2192-6506
- eISSN
- 2192-6506
- DOI
- 10.1002/cplu.201100010
- Publisher site
- See Article on Publisher Site
Abstract
Stranded on a nanoparticle: For the first time, zeolitic imidazolate framework‐8 nanoparticles (ZIFNPs) have been used in an effective fluorescent sensing platform for nucleic acids. The DNA detection is accomplished in two steps: 1) ZIFNPs adsorb and quench the dye‐labeled single‐stranded DNA probe, and 2) subsequent hybridization of the probe with its target produces double‐stranded DNA, which detaches from the ZIFNP. The present system shows a high selectivity down to single‐base mismatch (see figure).
Journal
ChemPlusChem – Wiley
Published: Jan 1, 2012