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Apoptosis, airway inflammation and anti‐asthma therapy: From immunobiology to clinical application

Apoptosis, airway inflammation and anti‐asthma therapy: From immunobiology to clinical application T lymphocyte apoptosis is essential for maintaining immune system homeostasis. Experimental evidence suggests apoptosis control mechanisms may be impaired in inflammatory conditions, particularly airway Th2‐type allergic diseases. This review briefly examines the mucosal immune system homeostasis and common apoptotic pathways and discusses impaired apoptosis, allergy, airway inflammation, remodelling and fibrosis. Finally, the paper presents an update on pharmacological targeting of apoptosis to control airway inflammation in patients with allergic asthma. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pediatric Allergy and Immunology Wiley

Apoptosis, airway inflammation and anti‐asthma therapy: From immunobiology to clinical application

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References (90)

Publisher
Wiley
Copyright
© 2008 The Authors. Journal compilation © 2008 Blackwell Munksgaard
ISSN
0905-6157
eISSN
1399-3038
DOI
10.1111/j.1399-3038.2007.00668.x
pmid
18179617
Publisher site
See Article on Publisher Site

Abstract

T lymphocyte apoptosis is essential for maintaining immune system homeostasis. Experimental evidence suggests apoptosis control mechanisms may be impaired in inflammatory conditions, particularly airway Th2‐type allergic diseases. This review briefly examines the mucosal immune system homeostasis and common apoptotic pathways and discusses impaired apoptosis, allergy, airway inflammation, remodelling and fibrosis. Finally, the paper presents an update on pharmacological targeting of apoptosis to control airway inflammation in patients with allergic asthma.

Journal

Pediatric Allergy and ImmunologyWiley

Published: Jun 1, 2008

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