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Antineutrophil cytoplasmic antibodies (ANCA) in idiopathic pulmonary hemosiderosis

Antineutrophil cytoplasmic antibodies (ANCA) in idiopathic pulmonary hemosiderosis Four children were diagnosed with idiopathic pulmonary hemosiderosis (IPH), over a period of 4 years. Retrospectively, antineutrophil cytoplasmic antibodies (ANCA) were studied by indirect immunofluorescence (IIF) and ELISA in 18 sera from these patients, stored at ‐20°C. ANCA‐positive sera, from 1/20 to 1/1, 200 dilution, were found in 3/4 of the patients, by IIF. The patient with the highest titre of ANCA died 3 months later during an acute crisis, the other two patients need a minimal dose of steroids. In one case only, a patient who is still without treatment, had no ANCA. The antibodies anti‐myeloperoxidase and anti‐pro‐teinase‐3 were negative or at border line levels. Rheumatoid factor, anti‐nuclear (Hep‐2), anti‐endomysial, anti‐reticulin and antibasement membrane antibodies were negative in all sera. The surviving patients were followed‐up for more than 10 years with no systemic or renal disease appearences. The presence of serum ANCA may help to classify children with pulmonary haemorrhage and may have a prognostic value. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pediatric Allergy and Immunology Wiley

Antineutrophil cytoplasmic antibodies (ANCA) in idiopathic pulmonary hemosiderosis

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References (17)

Publisher
Wiley
Copyright
Copyright © 1994 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0905-6157
eISSN
1399-3038
DOI
10.1111/j.1399-3038.1994.tb00246.x
Publisher site
See Article on Publisher Site

Abstract

Four children were diagnosed with idiopathic pulmonary hemosiderosis (IPH), over a period of 4 years. Retrospectively, antineutrophil cytoplasmic antibodies (ANCA) were studied by indirect immunofluorescence (IIF) and ELISA in 18 sera from these patients, stored at ‐20°C. ANCA‐positive sera, from 1/20 to 1/1, 200 dilution, were found in 3/4 of the patients, by IIF. The patient with the highest titre of ANCA died 3 months later during an acute crisis, the other two patients need a minimal dose of steroids. In one case only, a patient who is still without treatment, had no ANCA. The antibodies anti‐myeloperoxidase and anti‐pro‐teinase‐3 were negative or at border line levels. Rheumatoid factor, anti‐nuclear (Hep‐2), anti‐endomysial, anti‐reticulin and antibasement membrane antibodies were negative in all sera. The surviving patients were followed‐up for more than 10 years with no systemic or renal disease appearences. The presence of serum ANCA may help to classify children with pulmonary haemorrhage and may have a prognostic value.

Journal

Pediatric Allergy and ImmunologyWiley

Published: Nov 1, 1994

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