Access the full text.
Sign up today, get DeepDyve free for 14 days.
Schuurman Schuurman, Cheng Cheng, Lam Lam (2003)
Histopathology of xenograft rejection: a commentaryXenotransplantation, 10
H. Schuurman, Jane Cheng, T. Lam (2003)
Pathology of xenograft rejection: a commentaryXenotransplantation, 10
Production of (cid:1) -1,3-galactosyltransferase null pigs by means of nuclear transfer with fibroblasts bearing loss of heterozygosity mutations
K. Menninger, G. Wieczorek, S. Riesen, A. Kunkler, M. Audet, A. Blancher, H. Schuurman, V. Quesniaux, M. Bigaud (2002)
The origin of cynomolgus monkey affects the outcome of kidney allografts under Neoral immunosuppression.Transplantation proceedings, 34 7
R. Mañez, F. Blanco, I. Díaz, A. Centeno, E. López-Peláez, M. Hermida, H. Davies, A. Katopodis (2001)
Removal of bowel aerobic gram‐negative bacteria is more effective than immunosuppression with cyclophosphamide and steroids to decrease natural α‐Galactosyl IgG antibodiesXenotransplantation, 8
B. Holmes, A. Richards, M. Awwad, L. Copeman, M. McLaughlin, E. Cozzi, H. Schuurman, H. Davies (2002)
Anti‐pig antibody levels in naïve baboons and cynomolgus monkeysXenotransplantation, 9
A. Richards, H. Davies, M. McLaughlin, L. Copeman, B. Holmes, G. Cruz, S. Bycroft, G. Chavez, D. White, H. Schuurman, E. Cozzi (2002)
Serum anti-pig antibodies as potential indicators of acute humoral xenograft rejection in pig-to-cynomolgus monkey kidney transplantationTransplantation, 73
J. Seebach, Mårten Schneider, C. Comrack, A. Leguern, S. Kolb, P. Knolle, S. Germana, H. Dersimonian, C. Leguern, D. Sachs (2001)
Immortalized bone‐marrow derived pig endothelial cellsXenotransplantation, 8
C. Taylor, K. Tang, S. Smith, D. White, H. Davies (1998)
HLA-specific antibodies in highly sensitized patients can cause a positive crossmatch against pig lymphocytes.Transplantation, 65 12
K. Teranishi, R. Mañez, M. Awwad, D. Cooper (2002)
Anti‐Galα1‐3Gal IgM and IgG antibody levels in sera of humans and old world non‐human primatesXenotransplantation, 9
Kolber‐Simonds Kolber‐Simonds, Lai Lai, Watt Watt (2004)
Production of alpha‐1,3‐galactosyltransferase null pigs via nuclear transfer with fibroblasts bearing loss of heterozygosity mutationsProc Natl Acad Sci USA
Carol Phelps, Chihiro Koike, T. Vaught, J. Boone, Kevin Wells, Shu-Hung Chen, S. Ball, S. Specht, I. Polejaeva, Jeff Monahan, P. Jobst, Sugandha Sharma, Ashley Lamborn, A. Garst, Marilyn Moore, A. Demetris, W. Rudert, R. Bottino, S. Bertera, Massimo Trucco, Thomas Starzl, Yifan Dai, D. Ayares (2002)
Production of α1,3-Galactosyltransferase-Deficient PigsScience, 299
(2002)
AntiGala1-3Gal IgM and IgG antibody levels in sera of humans and Old World non-human primates
Abstract: Background: Natural anti‐porcine antibodies play a major role in hyperacute solid organ xenograft rejection in the pig‐to‐non‐human primate model. Work from other groups and our experience in transplantation experiments has shown that antibody levels are highly variable between non‐human primate species, and that extremely high levels can mediate hyperacute rejection even if organs from animals transgenic for human decay‐accelerating factor are used. Methods: Sera were obtained from cynomolgus monkeys wild‐caught in Mauritius, captive‐bred in the Philippines, captive‐bred in Indonesia (Indonesia‐Ind), and originating from Indonesia but colony‐bred in USA (Indonesia‐USA), from baboons wild‐caught in Kenya, and from rhesus monkeys originating from India but colony‐bred in USA (10 animals in each group). Antibody levels were determined using assays for haemolytic antibody (APA), IgM and IgG class anti‐Galα1‐3Gal antibody, and IgM and IgG class anti‐endothelial cell antibody. Results: Cynomolgus monkeys from the Philippines and Indonesia‐USA and rhesus monkeys showed median APA and IgM antibody levels in the same range as a pooled human serum standard, and median IgG levels well below the level in this standard. Cynomolgus monkeys from Mauritius and Indonesia‐Ind showed extremely high APA levels (median seven to 10 times the human serum standard): IgM class antibodies were also higher, while IgG class antibodies were in the range of the level in the human serum standard. Antibody levels in baboons were in between these two categories. The results of the APA assay showed a highly statistically significant correlation with the assays of IgM antibody, and this was also the case for the IgM antibody assays, indicative of the assessment of the same antibodies in these assays. The same was observed for the assays for IgG antibody. Taking body weight as an indicator for age, there was no relationship between body weight and levels of antibodies. Conclusions: Natural antibody levels show a significant variation between various groups of non‐human primates, with levels in some groups well above those in a human serum standard.
Xenotransplantation – Wiley
Published: Jul 1, 2004
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.