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References (19)
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J. Stene (1970)
Comparison of segregation ratios for families ascertained in different waysAnnals of Human Genetics, 33
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Familial Mongolism (Trisomy-21 Syndrome) Resulting from a "15/21" Chromosome Translocation in More than Three Generations of a Large Kindred.American journal of human genetics, 14 4
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Familial Down's syndromeAnn. Hum. Genet., 30
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A classification of methods of ascertainment and analysis in estimating the frequences FINNEY -
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Statistical inference on segregation ratios for D/G‐translocations, when the families are ascertained in different waysAnnals of Human Genetics, 34
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Cytogenetisch onderzoek, bij enige familim. Drukkerij-Uitgeverij Brakkenstein
- Publisher
- Wiley
- Copyright
- Copyright © 1970 Wiley Subscription Services, Inc., A Wiley Company
- ISSN
- 0003-4800
- eISSN
- 1469-1809
- DOI
- 10.1111/j.1469-1809.1970.tb01651.x
- Publisher site
- See Article on Publisher Site
Abstract
Analysis of segregation patterns between sibships within families ascertained in different ways BY JON STENE Institute of M e d i d Genetics and Institute of Xtatistics, University of Copenhagen 1. INTRODUCTION The analysis of segregation ratio when the families are brought into the material by some type of ascertainment has been discussed by many authors (see Bailey (1952), Morton (l959), Rao (1965) and Smith (1959) for references). The statistical methods for the analysis of such type of data are based upon the assumption that the abnormals by whom the families are ascertained are either recessive or dominant for a single gene, and that the occurrence of a single abnormal in the sibship is a sufficient condition for the family to be ascertained. The ascertainment is assumed to be of the same type for all families in the material. The familiesunder consideration are always defined as a sibship and their parents. The first assumption has been somewhat modified by Rao (1965), who considers some other types of data, but the literature seems to be short of methods to compare different sibships within a family and to compare families which consist of several sibships and are ascertained in different
Journal
Annals of Human Genetics – Wiley
Published: Jan 1, 1970