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An Efficient Synthesis of 1,3‐Disubstituted Pyrazoles from 2‐Acylaziridines

An Efficient Synthesis of 1,3‐Disubstituted Pyrazoles from 2‐Acylaziridines We developed an efficient and environmentally benign method for pyrazole synthesis by condensation between 2‐acylaziridines and hydrazine‐CO2 salts in high yields. The sequential reactions involved include an acid‐catalyzed intramolecular aziridine ring opening and a subsequent benzylamine elimination. In additional to the ease of handling the hydrazine as a solid without any smell, all of the processes were carried out with no organic solvent, except for a small amount of phenol as an acid catalyst. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Asian Journal of Organic Chemistry Wiley

An Efficient Synthesis of 1,3‐Disubstituted Pyrazoles from 2‐Acylaziridines

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References (35)

Publisher
Wiley
Copyright
© 2019 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim
ISSN
2193-5807
eISSN
2193-5815
DOI
10.1002/ajoc.201900233
Publisher site
See Article on Publisher Site

Abstract

We developed an efficient and environmentally benign method for pyrazole synthesis by condensation between 2‐acylaziridines and hydrazine‐CO2 salts in high yields. The sequential reactions involved include an acid‐catalyzed intramolecular aziridine ring opening and a subsequent benzylamine elimination. In additional to the ease of handling the hydrazine as a solid without any smell, all of the processes were carried out with no organic solvent, except for a small amount of phenol as an acid catalyst.

Journal

Asian Journal of Organic ChemistryWiley

Published: Sep 1, 2019

Keywords: ; ; ; ;

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