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An efficient and green method for the synthesis of N ‐phosphoramino o ‐hydroxylphenyl α‐aminophosphonic monoesters

An efficient and green method for the synthesis of N ‐phosphoramino o ‐hydroxylphenyl... An efficient and green method to the synthesis of N‐protected o‐hydroxylphenyl α‐amino‐alkylphosphonic monoesters is described. It consists of the three‐component Mannich‐type reaction of phosphoramides, carbonyl compounds (aldehydes or ketones), and 2‐chlorobenzo(1,3,2) diox‐aphospholes under solvent‐free and catalyst‐free conditions, followed by hydrolysis. © 2008 Wiley Periodicals, Inc. Heteroatom Chem 19:596–601, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20483 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Heteroatom Chemistry Wiley

An efficient and green method for the synthesis of N ‐phosphoramino o ‐hydroxylphenyl α‐aminophosphonic monoesters

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References (22)

Publisher
Wiley
Copyright
Copyright © 2008 Wiley Periodicals, Inc.
ISSN
1042-7163
eISSN
1098-1071
DOI
10.1002/hc.20483
Publisher site
See Article on Publisher Site

Abstract

An efficient and green method to the synthesis of N‐protected o‐hydroxylphenyl α‐amino‐alkylphosphonic monoesters is described. It consists of the three‐component Mannich‐type reaction of phosphoramides, carbonyl compounds (aldehydes or ketones), and 2‐chlorobenzo(1,3,2) diox‐aphospholes under solvent‐free and catalyst‐free conditions, followed by hydrolysis. © 2008 Wiley Periodicals, Inc. Heteroatom Chem 19:596–601, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20483

Journal

Heteroatom ChemistryWiley

Published: Sep 1, 2008

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