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AbbreviationsAPPalginate‐polylysine polymersASCcanine adipose stromal cellsAtgladipose triglyceride lipaseBRLBRL‐49653 (Rosiglitazone)BSAbovine serum albuminCIDcollision‐induced dissociationCScalf serumDIGEdifference gel electrophoresisDMEMDulbecco's Modified Eagle MediumFabp4fatty acid binding protein 4FBSfetal bovine serumHEPES4‐(2‐hydroxyethyl)‐1‐piperazineethanesulfonic acidIEFisoelectric focusingKOknockoutLCN2lipokalin 2LTQlinear trap quadrupoleMGFmascot generic filesMSmass spectrometryNGALneutrophil gelatinase‐associated lipocalinPBSphosphate‐buffered salinePCAprincipal component analysisPCRpolymerase chain reactionPpargperoxisome proliferator‐activated receptor gammaRaldretinaldehydeRBP4retinol binding protein 4SDS‐PAGEsodium dodecyl sulfate polyacrylamide gel electrophoresisUcp1uncoupling protein 1WTwild typeZfp423zinc finger protein 423INTRODUCTIONXenotransplantation of organs, specific cell populations, and genetically engineered cells continue to be investigated to address shortage of donor organs and for the treatment of genetic, autoimmune, and degenerative diseases. The survival and longevity of xenografts depend on interaction with the host immune system as well as an ability to integrate into the host's metabolism and energy pathways. Three decades of research led to considerable progress in the identification of hallmarks and mechanisms leading to immune rejection. Together, these efforts resulted in a considerable improvement in xenograft survival. The importance of energy pathways was revealed in context of cancer xenografts in immunosuppressed mice. Energy exchange between different species is also the basis for xenografts' longevity; however, mechanisms for cross talk establishing energy homeostasis between cells from different species remain understudied.Studies demonstrate functional survival of xenografts encapsulated into alginate‐polylysine polymers (APP) for the production of catecholamines
Xenotransplantation – Wiley
Published: Sep 1, 2017
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