Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Age‐related deficits on the radial maze and in fear conditioning: Hippocampal processing and consolidation

Age‐related deficits on the radial maze and in fear conditioning: Hippocampal processing and... Young adult, middle‐aged, and old male F‐344 rats were assessed for their hippocampal ability. This was accomplished by examining the animals on two different paradigms, each incorporating a simultaneous measure of hippocampal‐dependent and ‐independent processing. The animals were fear conditioned and then tested for retention of the conditioning context and tone. This was followed by an 8‐arm radial maze task which combined spatial working and cued reference memory elements. The two paradigms are compared in terms of task demands, potential confounds, and validity for aging studies. The results indicate that the performance of the animals on the two tasks is correlated. Age‐related deficits limited to the hippocampal aspects of the above tasks were found, with no deficits found in the analogous but hippocampus‐independent aspects of these tasks. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Hippocampus Wiley

Age‐related deficits on the radial maze and in fear conditioning: Hippocampal processing and consolidation

Oler, Jonathan A.; Markus, Etan J.
Hippocampus , Volume 8 (4) – Jan 1, 1998
Download PDF
14 pages

Loading next page...
 
/lp/wiley/age-related-deficits-on-the-radial-maze-and-in-fear-conditioning-wT2AOTPTPu

References (80)

Publisher
Wiley
Copyright
Copyright © 1998 Wiley Subscription Services
ISSN
1050-9631
eISSN
1098-1063
DOI
10.1002/(SICI)1098-1063(1998)8:4<402::AID-HIPO8>3.0.CO;2-I
Publisher site
See Article on Publisher Site

Abstract

Young adult, middle‐aged, and old male F‐344 rats were assessed for their hippocampal ability. This was accomplished by examining the animals on two different paradigms, each incorporating a simultaneous measure of hippocampal‐dependent and ‐independent processing. The animals were fear conditioned and then tested for retention of the conditioning context and tone. This was followed by an 8‐arm radial maze task which combined spatial working and cued reference memory elements. The two paradigms are compared in terms of task demands, potential confounds, and validity for aging studies. The results indicate that the performance of the animals on the two tasks is correlated. Age‐related deficits limited to the hippocampal aspects of the above tasks were found, with no deficits found in the analogous but hippocampus‐independent aspects of these tasks.

Journal

Hippocampus – Wiley

Published: Jan 1, 1998

Keywords: ; ; ; ; ;

There are no references for this article.