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Advances in Uniform Polymer Microspheres and Microcapsules: Preparation and Biomedical Applications

Advances in Uniform Polymer Microspheres and Microcapsules: Preparation and Biomedical Applications Microspheres and microcapsules have been widely used in biomedical field, such as delivery systems for drugs, vaccines. Uniform particle is required for precise drug delivery and disease treatment, since the particle diameter is a key factor which controls the pharmacokinetics and efficacy of loaded drug. However, there is no universal method to prepare uniform particles either from monomer or preformed polymer raw materials. We have developed two membrane emulsification techniques (MET) to prepare uniform particles with controllable size. In this review, we introduce two MET processes and their mechanisms, and how to develop MET to different emulsion systems to obtain various uniform microspheres and microcapsules with interesting morphologies. Then, the advantages of uniform particles on biomedical application results are focused. Finally, particle design and applications as “Chassis” to form synthetic vaccine are described. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Chinese Journal of Chemistry Wiley

Advances in Uniform Polymer Microspheres and Microcapsules: Preparation and Biomedical Applications

Chinese Journal of Chemistry , Volume 38 (9) – Sep 1, 2020

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References (77)

Publisher
Wiley
Copyright
© 2020 SIOC, CAS, Shanghai & WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim
ISSN
1001-604X
eISSN
1614-7065
DOI
10.1002/cjoc.202000135
Publisher site
See Article on Publisher Site

Abstract

Microspheres and microcapsules have been widely used in biomedical field, such as delivery systems for drugs, vaccines. Uniform particle is required for precise drug delivery and disease treatment, since the particle diameter is a key factor which controls the pharmacokinetics and efficacy of loaded drug. However, there is no universal method to prepare uniform particles either from monomer or preformed polymer raw materials. We have developed two membrane emulsification techniques (MET) to prepare uniform particles with controllable size. In this review, we introduce two MET processes and their mechanisms, and how to develop MET to different emulsion systems to obtain various uniform microspheres and microcapsules with interesting morphologies. Then, the advantages of uniform particles on biomedical application results are focused. Finally, particle design and applications as “Chassis” to form synthetic vaccine are described.

Journal

Chinese Journal of ChemistryWiley

Published: Sep 1, 2020

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