Access the full text.
Sign up today, get DeepDyve free for 14 days.
Rui-Juan Lv, Qun Wang, Tao Cui, Fei Zhu, Xiao-Qiu Shao (2017)
Status epilepticus-related etiology, incidence and mortality: A meta-analysisEpilepsy Research, 136
Jason Snyder, Jessica Choe, Meredith Clifford, Sara Jeurling, Patrick Hurley, Ashly Brown, J. Kamhi, H. Cameron (2009)
Adult-Born Hippocampal Neurons Are More Numerous, Faster Maturing, and More Involved in Behavior in Rats than in MiceThe Journal of Neuroscience, 29
T. Kirino (1982)
Delayed neuronal death in the gerbil hippocampus following ischemiaBrain Research, 239
H. Scharfman (1999)
The role of nonprincipal cells in dentate gyrus excitability and its relevance to animal models of epilepsy and temporal lobe epilepsy.Advances in neurology, 79
J. Maguire (2014)
Stress-induced plasticity of GABAergic inhibitionFrontiers in Cellular Neuroscience, 8
Yashmin Karten, Meredith Jones, Sara Jeurling, H. Cameron (2006)
GABAergic signaling in young granule cells in the adult rat and mouse dentate gyrusHippocampus, 16
L. Mongiat, M. Soledad, Espó Sito, G. Lombardi, A. Schinder, T. Reh (2009)
Reliable Activation of Immature Neurons in the Adult HippocampusPLoS ONE, 4
G. Kempermann, H. Kuhn, F. Gage (1997)
Genetic influence on neurogenesis in the dentate gyrus of adult mice.Proceedings of the National Academy of Sciences of the United States of America, 94 19
C. Dinocourt, Z. Petanjek, T. Freund, Y. Ben‐Ari, M. Esclapez (2003)
Loss of interneurons innervating pyramidal cell dendrites and axon initial segments in the CA1 region of the hippocampus following pilocarpine‐induced seizuresJournal of Comparative Neurology, 459
M. England, C. Liverman, Andrea Schultz, Larisa Strawbridge (2012)
Epilepsy across the spectrum: Promoting health and understanding. A summary of the Institute of Medicine reportEpilepsy & Behavior, 25
Désirée Seib, Delane Espinueva, Oren Princz-Lebel, Erin Chahley, Jordann Stevenson, Timothy O’Leary, S. Floresco, Jason Snyder (2021)
Hippocampal neurogenesis promotes preference for future rewardsMolecular Psychiatry, 26
Jason Snyder, A. Soumier, Michelle Brewer, J. Pickel, H. Cameron (2011)
Adult hippocampal neurogenesis buffers stress responses and depressive behaviorNature, 476
P. Nelson, Charles Smith, E. Abner, Bernard Wilfred, Wang-Xia Wang, J. Neltner, M. Baker, D. Fardo, R. Kryscio, S. Scheff, G. Jicha, K. Jellinger, L. Eldik, F. Schmitt (2013)
Hippocampal sclerosis of aging, a prevalent and high-morbidity brain diseaseActa Neuropathologica, 126
Lian Wang, Yong-hong Liu, Yuan-gui Huang, Liang-Wei Chen (2008)
Time-course of neuronal death in the mouse pilocarpine model of chronic epilepsy using Fluoro-Jade C stainingBrain Research, 1241
D. Lowenstein, M. Thomas, Dh Smith, T. Mcintosh (1992)
Selective vulnerability of dentate hilar neurons following traumatic brain injury: a potential mechanistic link between head trauma and disorders of the hippocampus, 12
Nadler Jv (1981)
Kainic acid as a tool for the study of temporal lobe epilepsyLife Sciences, 29
H. Scharfman, Hannah Bernstein (2015)
Potential implications of a monosynaptic pathway from mossy cells to adult-born granule cells of the dentate gyrusFrontiers in Systems Neuroscience, 9
D. Amaral (1978)
A golgi study of cell types in the hilar region of the hippocampus in the ratJournal of Comparative Neurology, 182
Esther Krook-Magnuson, Caren Armstrong, Anh Bui, S. Lew, M. Oijala, I. Soltesz (2015)
In vivo evaluation of the dentate gate theory in epilepsyThe Journal of Physiology, 593
E. Lothman, J. Stringer, E. Bertram (1992)
The dentate gyrus as a control point for seizures in the hippocampus and beyond.Epilepsy research. Supplement, 7
Yosuke Niibori, Tzong-Shiue Yu, J. Epp, K. Akers, S. Josselyn, P. Frankland (2012)
Suppression of adult neurogenesis impairs population coding of similar contexts in hippocampal CA3 regionNature communications, 3
T. Uemori, Keiko Toda, T. Seki (2017)
Seizure severity‐dependent selective vulnerability of the granule cell layer and aberrant neurogenesis in the rat hippocampusHippocampus, 27
K. Spielmann, R. Vliet, W. Sandt-Koenderman, M. Frens, G. Ribbers, R. Selles, S. Vugt, J. Geest, P. Holland (2017)
Cerebellar Cathodal Transcranial Direct Stimulation and Performance on a Verb Generation Task: A Replication StudyNeural Plasticity, 2017
E. Trinka, Hannah Cock, D. Hesdorffer, A. Rossetti, I. Scheffer, S. Shinnar, S. Shorvon, D. Lowenstein (2015)
A definition and classification of status epilepticus – Report of the ILAE Task Force on Classification of Status EpilepticusEpilepsia, 56
T. L. Babb, J. K. Pretorius (1993)
The treatment of epilepsy: Principles and practice
H. Scharfman, Anne Sollas, Karen Smith, M. Jackson, J. Goodman (2002)
Structural and functional asymmetry in the normal and epileptic rat dentate gyrusJournal of Comparative Neurology, 454
J. Botterill, K. Brymer, H. Caruncho, L. Kalynchuk (2015)
Aberrant hippocampal neurogenesis after limbic kindling: Relationship to BDNF and hippocampal-dependent memoryEpilepsy & Behavior, 47
R. Racine (1972)
Modification of seizure activity by electrical stimulation. II. Motor seizure.Electroencephalography and clinical neurophysiology, 32 3
M. Thomé-Souza, E. Kuczynski, K. Valente (2007)
Sertraline and fluoxetine: Safe treatments for children and adolescents with epilepsy and depressionEpilepsy & Behavior, 10
M. England, C. Liverman, Andrea Schultz, Larisa Strawbridge (2012)
Epilepsy Across the Spectrum
(2020)
Mesial temporal lobe epilepsy with hippocampal sclerosisDefinitions
Sloka Iyengar, J. Lafrancois, D. Friedman, L. Drew, C. Denny, N. Burghardt, Melody Wu, Jenny Hsieh, R. Hen, H. Scharfman (2015)
Suppression of Adult Neurogenesis Increases the Acute Effects of Kainic AcidExperimental Neurology, 264
P. Patrylo, I. Tyagi, Amy Willingham, Sung Lee, A. Williamson (2007)
Dentate Filter Function Is Altered in a Proepileptic Fashion during AgingEpilepsia, 48
Jason Brown, S. Couillard-Després, C. Cooper-Kuhn, J. Winkler, L. Aigner, H. Kuhn (2003)
Transient expression of doublecortin during adult neurogenesisJournal of Comparative Neurology, 467
C. Clelland, M. Choi, C. Romberg, G. Clemenson, A. Fragniere, P. Tyers, S. Jessberger, L. Saksida, R. Barker, F. Gage, T. Bussey (2009)
A Functional Role for Adult Hippocampal Neurogenesis in Spatial Pattern SeparationScience, 325
I. Soltesz, A. Losonczy (2018)
CA1 pyramidal cell diversity enabling parallel information processing in the hippocampusNature Neuroscience, 21
Matthew Korn, Quinton Mandle, J. Parent (2016)
Conditional Disabled-1 Deletion in Mice Alters Hippocampal Neurogenesis and Reduces Seizure ThresholdFrontiers in Neuroscience, 10
B. Meldrum (2002)
Concept of activity-induced cell death in epilepsy: historical and contemporary perspectives.Progress in brain research, 135
L. Santarelli, M. Saxe, C. Gross, A. Surget, F. Battaglia, S. Dulawa, N. Weisstaub, James Lee, R. Duman, O. Arancio, C. Belzung, R. Hen (2003)
Requirement of Hippocampal Neurogenesis for the Behavioral Effects of AntidepressantsScience, 301
L. Čulig, A. Surget, Marlene Bourdey, W. Khemissi, A. Guisquet, E. Vogel, Amar Sahay, R. Hen, C. Belzung (2017)
Increasing adult hippocampal neurogenesis in mice after exposure to unpredictable chronic mild stress may counteract some of the effects of stressNeuropharmacology, 126
Kyung-Ok Cho, Zane Lybrand, Naoki Ito, Rebecca Brulet, Farrah Tafacory, Ling Zhang, L. Good, Kerstin Ure, S. Kernie, S. Birnbaum, H. Scharfman, A. Eisch, Jenny Hsieh (2015)
Aberrant hippocampal neurogenesis contributes to epilepsy and associated cognitive declineNature Communications, 6
R. Schloesser, H. Manji, K. Martinowich (2009)
Suppression of adult neurogenesis leads to an increased hypothalamo-pituitary-adrenal axis responseNeuroReport, 20
H. Georg, Kuhn, Heather, Dickinson-Anson, Fred, H. Gage (1996)
Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation, 16
C. Brandt, Kathrin Töllner, R. Klee, S. Bröer, W. Löscher (2015)
Effective termination of status epilepticus by rational polypharmacy in the lithium–pilocarpine model in rats: Window of opportunity to prevent epilepsy and prediction of epilepsy by biomarkersNeurobiology of Disease, 75
S. Ge, K. Sailor, G. Ming, Hongjun Song (2008)
Synaptic integration and plasticity of new neurons in the adult hippocampusThe Journal of Physiology, 586
F. Bouckaert, P. Sienaert, J. Obbels, A. Dols, M. Vandenbulcke, M. Stek, T. Bolwig (2014)
ECT: Its Brain Enabling Effects A Review of Electroconvulsive Therapy–Induced Structural Brain PlasticityThe Journal of ECT, 30
M. Drew, C. Denny, R. Hen (2010)
Arrest of adult hippocampal neurogenesis in mice impairs single- but not multiple-trial contextual fear conditioning.Behavioral neuroscience, 124 4
C. Myers, Keria Bermudez-Hernandez, H. Scharfman (2013)
The Influence of Ectopic Migration of Granule Cells into the Hilus on Dentate Gyrus-CA3 FunctionPLoS ONE, 8
Chunmei Zhao, Wei Deng, F. Gage (2008)
Mechanisms and Functional Implications of Adult NeurogenesisCell, 132
S. Herman (2002)
Epilepsy after brain insult: Targeting epileptogenesisNeurology, 59
H. Scharfman, J. Goodman, Marie‐Aude Rigoulot, R. Berger, S. Walling, T. Mercurio, K. Stormes, N. MacLusky (2005)
Seizure susceptibility in intact and ovariectomized female rats treated with the convulsant pilocarpineExperimental Neurology, 196
J. Gleeson, P. Lin, L. Flanagan, C. Walsh (1999)
Doublecortin Is a Microtubule-Associated Protein and Is Expressed Widely by Migrating NeuronsNeuron, 23
D. Cain, M. Corcoran (1984)
Intracerebral beta-endorphin, met-enkephalin and morphine: kindling of seizures and handling-induced potentiation of epileptiform effects.Life sciences, 34 25
J. Altman (2011)
The Discovery of Adult Mammalian Neurogenesis
Kevin Phelan, U. Shwe, David Williams, L. Greenfield, Fang Zheng (2015)
Pilocarpine-induced status epilepticus in mice: A comparison of spectral analysis of electroencephalogram and behavioral grading using the Racine scaleEpilepsy Research, 117
Ramses Ribot, B. Ouyang, A. Kanner (2017)
The impact of antidepressants on seizure frequency and depressive and anxiety disorders of patients with epilepsy: Is it worth investigating?Epilepsy & Behavior, 70
Jan Frankowski, Young Kim, Robert Hunt (2019)
Selective vulnerability of hippocampal interneurons to graded traumatic brain injuryNeurobiology of Disease, 129
Song Jiao, Zheng Li (2011)
Nonapoptotic Function of BAD and BAX in Long-Term Depression of Synaptic TransmissionNeuron, 70
H. Scharfman (2004)
Functional implications of seizure-induced neurogenesis.Advances in experimental medicine and biology, 548
F. Bartolomei, Fabrice Wendling, Jean Régis, M. Gavaret, Maxime Guye, P. Chauvel (2004)
Pre-ictal synchronicity in limbic networks of mesial temporal lobe epilepsyEpilepsy Research, 61
C. Anacker, R. Hen (2017)
Adult hippocampal neurogenesis and cognitive flexibility — linking memory and moodNature Reviews Neuroscience, 18
Lynette Sadleir, Ingrid Scheffer (2007)
Febrile seizuresBMJ : British Medical Journal, 334
I. Módy, T. Otis, A. Bragin, M. Hsu, G. Buzsáki (1995)
GABAergic inhibition of granule cells and hilar neuronal synchrony following ischemia-induced hilar neuronal lossNeuroscience, 69
R. Racine (1975)
Modification of seizure activity by electrical stimulation: cortical areas.Electroencephalography and clinical neurophysiology, 38 1
C. Schmidt-Hieber, P. Jonas, J. Bischofberger (2004)
Enhanced synaptic plasticity in newly generated granule cells of the adult hippocampusNature, 429
L. Covolan, Luiz Mello (2000)
Temporal profile of neuronal injury following pilocarpine or kainic acid-induced status epilepticusEpilepsy Research, 39
J. Weise, T. Engelhorn, A. Dörfler, S. Aker, M. Bähr, A. Hufnagel (2005)
Expression time course and spatial distribution of activated caspase-3 after experimental status epilepticus: Contribution of delayed neuronal cell death to seizure-induced neuronal injuryNeurobiology of Disease, 18
J. Ekstrand, W. Pouliot, P. Scheerlinck, F. Dudek (2011)
Lithium pilocarpine-induced status epilepticus in postnatal day 20 rats results in greater neuronal injury in ventral versus dorsal hippocampusNeuroscience, 192
Kaplan, Jw Hinds (1977)
Neurogenesis in the adult rat: electron microscopic analysis of light radioautographs.Science, 197 4308
B. Singer, A. Gamelli, Cynthia Fuller, Stephanie Temme, J. Parent, G. Murphy (2011)
Compensatory network changes in the dentate gyrus restore long-term potentiation following ablation of neurogenesis in young-adult miceProceedings of the National Academy of Sciences, 108
U. Fischer, S. Steffens, S. Frank, N. Rainov, K. Schulze-Osthoff, C. Kramm (2005)
Mechanisms of thymidine kinase/ganciclovir and cytosine deaminase/ 5-fluorocytosine suicide gene therapy-induced cell death in glioma cellsOncogene, 24
M. Olesen, G. Wörtwein, Jonas Folke, B. Pakkenberg (2017)
Electroconvulsive stimulation results in long‐term survival of newly generated hippocampal neurons in ratsHippocampus, 27
Amar Sahay, Kimberly Scobie, Alexis Hill, C. O’Carroll, M. Kheirbek, N. Burghardt, A. Fenton, A. Dranovsky, R. Hen (2011)
Increasing adult hippocampal neurogenesis is sufficient to improve pattern separationNature, 472
N. Toni, D. Laplagne, Chunmei Zhao, G. Lombardi, C. Ribak, F. Gage, A. Schinder (2008)
Neurons born in the adult dentate gyrus form functional synapses with target cellsNature Neuroscience, 11
Phillip Connell, Arezou Bayat, Sweta Joshi, M. Koubeissi (2017)
Acute and spontaneous seizure onset zones in the intraperitoneal kainic acid modelEpilepsy & Behavior, 68
L. Mello, E. Cavalheiro, A. Tan, W. Kupfer, J. Pretorius, T. Babb, D. Finch (1993)
Circuit Mechanisms of Seizures in the Pilocarpine Model of Chronic Epilepsy: Cell Loss and Mossy Fiber SproutingEpilepsia, 34
(2017)
Relative timing of the initial neocortical and hippocampal seizure activity preceding kainic acidinduced status epilepticus in adult rats
Denise Garcia, Ngan Doan, T. Imura, T. Bush, M. Sofroniew (2004)
GFAP-expressing progenitors are the principal source of constitutive neurogenesis in adult mouse forebrainNature Neuroscience, 7
J. Moyer, V. Gnatkovsky, Tomonori Ono, J. Otáhal, Joost Wagenaar, W. Stacey, J. Noebels, A. Ikeda, K. Staley, M. Curtis, B. Litt, A. Galanopoulou (2017)
Standards for data acquisition and software‐based analysis of in vivo electroencephalography recordings from animals. A TASK1‐WG5 report of the AES/ILAE Translational Task Force of the ILAEEpilepsia, 58
K. Mizuseki, K. Diba, E. Pastalkova, G. Buzsáki (2011)
Hippocampal CA1 pyramidal cells form functionally distinct sublayersNature neuroscience, 14
Y. Ben‐Ari (2012)
Jasper's basic mechanisms of the epilepsies
M. Lunde, E. Lee, K. Rasmussen (2006)
Electroconvulsive therapy in patients with epilepsyEpilepsy & Behavior, 9
D. Wasserman (1992)
Genetic influenceNature, 359
Alain Bouthillier, S. Spencer, D. Spencer (1995)
Hippocampal sclerosisNeurology, 45
H. Scharfman, P. Schwartzkroin (1990)
Responses of cells of the rat fascia dentata to prolonged stimulation of the perforant path: Sensitivity of hilar cells and changes in granule cell excitabilityNeuroscience, 35
D. Hesdorffer, G. Logroscino, G. Cascino, J. Annegers, J. Annegers, W. Hauser, W. Hauser (1998)
Incidence of status epilepticus in Rochester, Minnesota, 1965-1984Neurology, 50
K. Borges, M. Gearing, Dayna McDermott, Amy Smith, Antoine Almonte, B. Wainer, R. Dingledine (2003)
Neuronal and glial pathological changes during epileptogenesis in the mouse pilocarpine modelExperimental Neurology, 182
F. Dudek, K. Staley (2012)
The Time Course and Circuit Mechanisms of Acquired Epileptogenesis
H. Scharfman, R. Hen (2007)
Is More Neurogenesis Always Better?Science, 315
J. Parent, D. Lowenstein (2002)
Seizure-induced neurogenesis: are more new neurons good for an adult brain?Progress in brain research, 135
J. Aimone, S. Jessberger, F. Gage (2007)
Adult neurogenesisScholarpedia, 2
Woong Sun, A. Winseck, S. Vinsant, Ok‐hee Park, H. Kim, R. Oppenheim (2004)
Programmed Cell Death of Adult-Generated Hippocampal Neurons Is Mediated by the Proapoptotic Gene BaxThe Journal of Neuroscience, 24
C. Shaw, E. Alvord (1997)
Neuropathology of the limbic system.Neuroimaging clinics of North America, 7 1
B. Grain, W. Westerkam, A. Harrison, J. Nadler (1988)
Selective neuronal death after transient forebrain ischemia in the mongolian gerbil: A silver impregnation studyNeuroscience, 27
R. Kalaria (2016)
Neuropathological diagnosis of vascular cognitive impairment and vascular dementia with implications for Alzheimer’s diseaseActa Neuropathologica, 131
Angela Walker, Phillip Rivera, Qian Wang, Jen Chuang, Stephanie Tran, S. Osborne-Lawrence, S. Estill, Ruth Starwalt, Paula Huntington, Lorraine Morlock, Jacinth Naidoo, Noelle Williams, J. Ready, Amelia Eisch, Andrew Pieper, J. Zigman (2014)
The P7C3 class of neuroprotective compounds exerts antidepressant efficacy in mice by increasing hippocampal neurogenesisMolecular Psychiatry, 20
S. Sanchez, F. Rincon (2016)
Status Epilepticus: Epidemiology and Public Health NeedsJournal of Clinical Medicine, 5
Keria Bermudez-Hernandez, Yi-Ling Lu, Jillian Moretto, Swati Jain, J. Lafrancois, Á. Duffy, H. Scharfman (2017)
Hilar granule cells of the mouse dentate gyrus: effects of age, septotemporal location, strain, and selective deletion of the proapoptotic gene BAXBrain Structure and Function, 222
T. Nakashiba, J. Cushman, K. Pelkey, S. Renaudineau, D. Buhl, T. McHugh, V. Barrera, R. Chittajallu, Keisuke Iwamoto, C. McBain, M. Fanselow, S. Tonegawa (2012)
Young Dentate Granule Cells Mediate Pattern Separation, whereas Old Granule Cells Facilitate Pattern CompletionCell, 149
J. Cavazos, T. Sutula (1990)
Progressive neuronal loss induced by kindling: a possible mechanism for mossy fiber synaptic reorganization and hippocampal sclerosisBrain Research, 527
L. Drew, M. Kheirbek, V. Luna, C. Denny, Megan Cloidt, Melody Wu, Swati Jain, H. Scharfman, R. Hen (2016)
Activation of local inhibitory circuits in the dentate gyrus by adult‐born neuronsHippocampus, 26
M. Sofroniew, T. Bush, Natalie Blumauer, L. Kruger, L. Mucke, Martin Johnson (1999)
Genetically-targeted and conditionally-regulated ablation of astroglial cells in the central, enteric and peripheral nervous systems in adult transgenic mice 1 Published on the World Wide Web on 7 June 1999. 1Brain Research, 835
Á. Duffy, M. Schaner, Synphen Wu, Agnieszka Staniszewski, Asok Kumar, J. Arévalo, O. Arancio, M. Chao, H. Scharfman (2011)
A selective role for ARMS/Kidins220 scaffold protein in spatial memory and trophic support of entorhinal and frontal cortical neuronsExperimental Neurology, 229
Cristina Dieni, Angela Nietz, R. Panichi, Jacques Wadiche, Linda Overstreet-Wadiche (2013)
Distinct Determinants of Sparse Activation during Granule Cell MaturationThe Journal of Neuroscience, 33
I. Kharatishvili, J. Nissinen, Tracy McIntosh, A. Pitkänen (2006)
A model of posttraumatic epilepsy induced by lateral fluid-percussion brain injury in ratsNeuroscience, 140
Sean Markwardt, Linda Overstreet-Wadiche (2008)
GABAergic signalling to adult‐generated neuronsThe Journal of Physiology, 586
H. Scharfman, N. MacLusky (2017)
Sex differences in hippocampal area CA3 pyramidal cellsJournal of Neuroscience Research, 95
C. Wasterlain, D. Fujikawa, Laroy Penix, R. Sankar (1993)
Pathophysiological Mechanisms of Brain Damage from Status EpilepticusEpilepsia, 34
J. Margerison, J. Corsellis (1966)
Epilepsy and the temporal lobes. A clinical, electroencephalographic and neuropathological study of the brain in epilepsy, with particular reference to the temporal lobes.Brain : a journal of neurology, 89 3
V. Skucas, Á. Duffy, Lauren Harte-Hargrove, Alejandra Magagna-Poveda, T. Radman, G. Chakraborty, C. Schroeder, N. MacLusky, H. Scharfman (2013)
Testosterone Depletion in Adult Male Rats Increases Mossy Fiber Transmission, LTP, and Sprouting in Area CA3 of HippocampusThe Journal of Neuroscience, 33
B. Swartz, C. Houser, U. Tomiyasu, G. Walsh, A. DeSalles, J. Rich, A. Delgado-Escueta (2006)
Hippocampal Cell Loss in Posttraumatic Human EpilepsyEpilepsia, 47
H. Praag, A. Schinder, B. Christie, N. Toni, T. Palmer, F. Gage (2002)
Functional neurogenesis in the adult hippocampusNature, 415
André Nascimento, N. Santos, Fernanda Pelágio, S. Teixeira, E. Ferrari, F. Langone (2012)
Neuronal degeneration and gliosis time-course in the mouse hippocampal formation after pilocarpine-induced status epilepticusBrain Research, 1470
Taruna Ikrar, N. Guo, Kai-Wen He, Antoine Besnard, Sally Levinson, Alexis Hill, Hey-Kyoung Lee, R. Hen, Xiangmin Xu, Amar Sahay (2013)
Adult neurogenesis modifies excitability of the dentate gyrusFrontiers in Neural Circuits, 7
J. Aimone, Yan Li, Star Lee, G. Clemenson, Wei Deng, F. Gage (2014)
Regulation and function of adult neurogenesis: from genes to cognition.Physiological reviews, 94 4
P. Taupin (2008)
Adult neurogenesis pharmacology in neurological diseases and disordersExpert Review of Neurotherapeutics, 8
Bo Feng, Zhong Chen (2016)
Generation of Febrile Seizures and Subsequent EpileptogenesisNeuroscience Bulletin, 32
R. Sloviter (1994)
The functional organization of the hippocampal dentate gyrus and its relevance to the pathogenesis of temporal lobe epilepsyAnnals of Neurology, 35
M. Tubi, E. Lutkenhoff, M. Blanco, D. McArthur, P. Villablanca, B. Ellingson, R. Diaz-Arrastia, P. Ness, Courtney Real, Vikesh Shrestha, J. Engel, P. Vespa (2019)
Early seizures and temporal lobe trauma predict post-traumatic epilepsy: A longitudinal studyNeurobiology of Disease, 123
P. Buckmaster, Megan Haney (2012)
Factors affecting outcomes of pilocarpine treatment in a mouse model of temporal lobe epilepsyEpilepsy Research, 102
Judes Poirier, R. Čapek, Y. Koninck (2000)
Differential progression of Dark Neuron and Fluoro-Jade labelling in the rat hippocampus following pilocarpine-induced status epilepticusNeuroscience, 97
H. Hamid, A. Kanner (2013)
Should antidepressant drugs of the selective serotonin reuptake inhibitor family be tested as antiepileptic drugs?Epilepsy & Behavior, 26
C. Anacker, V. Luna, Gregory Stevens, A. Millette, Ryan Shores, Jessica Jimenez, Briana Chen, R. Hen (2018)
Hippocampal neurogenesis confers stress resilience by inhibiting the ventral dentate gyrusNature, 559
H. Scharfman, J. Goodman, Anne Sollas (2000)
Granule-Like Neurons at the Hilar/CA3 Border after Status Epilepticus and Their Synchrony with Area CA3 Pyramidal Cells: Functional Implications of Seizure-Induced NeurogenesisThe Journal of Neuroscience, 20
M. Nilsson, E. Perfilieva, Ulf Johansson, O. Orwar, P. Eriksson (1999)
Enriched environment increases neurogenesis in the adult rat dentate gyrus and improves spatial memory.Journal of neurobiology, 39 4
K. Tse, Sreekanth Puttachary, Edward Beamer, G. Sills, T. Thippeswamy (2014)
Advantages of Repeated Low Dose against Single High Dose of Kainate in C57BL/6J Mouse Model of Status Epilepticus: Behavioral and Electroencephalographic StudiesPLoS ONE, 9
D. Fujikawa (1996)
The temporal evolution of neuronal damage from pilocarpine-induced status epilepticusBrain Research, 725
B. Meldrum (1991)
9. Excitotoxicity and epileptic brain damageEpilepsy Research, 10
Bethany Hosford, John Liska, S. Danzer (2016)
Ablation of Newly Generated Hippocampal Granule Cells Has Disease-Modifying Effects in EpilepsyThe Journal of Neuroscience, 36
A. Pieper, S. McKnight, J. Ready (2014)
P7C3 and an unbiased approach to drug discovery for neurodegenerative diseases.Chemical Society reviews, 43 19
A. Marin-Burgin, L. Mongiat, M. Pardi, A. Schinder (2012)
Unique Processing During a Period of High Excitation/Inhibition Balance in Adult-Born NeuronsScience, 335
C. Denny, N. Burghardt, Daniel Schachter, R. Hen, M. Drew (2012)
4‐ to 6‐week‐old adult‐born hippocampal neurons influence novelty‐evoked exploration and contextual fear conditioningHippocampus, 22
R. Schloesser, D. Jimenez, N. Hardy, D. Paredes, Briony Catlow, H. Manji, R. McKay, K. Martinowich (2014)
Atrophy of pyramidal neurons and increased stress-induced glutamate levels in CA3 following chronic suppression of adult neurogenesisBrain Structure and Function, 219
Ren-Zhi Zhan, O. Timofeeva, J. Nadler, Ren-Zhi Zhan, Timofeeva Nadler, Jv High, J. Nadler (2010)
High ratio of synaptic excitation to synaptic inhibition in hilar ectopic granule cells of pilocarpine-treated rats.Journal of neurophysiology, 104 6
Kylie Huckleberry, Francis Shue, Taylor Copeland, R. Chitwood, W. Yin, M. Drew (2018)
Dorsal and ventral hippocampal adult-born neurons contribute to context fear memoryNeuropsychopharmacology, 43
C. Dengler, D. Coulter (2016)
Normal and epilepsy-associated pathologic function of the dentate gyrus.Progress in brain research, 226
Deana Apple, R. Fonseca, Erzsebet Kokovay (2017)
The role of adult neurogenesis in psychiatric and cognitive disordersBrain Research, 1655
P. Ambrogini, D. Lattanzi, S. Ciuffoli, D. Agostini, L. Bertini, V. Stocchi, S. Santi, R. Cuppini (2004)
Morpho-functional characterization of neuronal cells at different stages of maturation in granule cell layer of adult rat dentate gyrusBrain Research, 1017
Yan Gu, M. Arruda-Carvalho, Jia Wang, Stephen Janoschka, S. Josselyn, P. Frankland, S. Ge (2012)
Optical controlling reveals time-dependent roles for adult-born dentate granule cellsNature neuroscience, 15
J. Parent, G. Murphy (2008)
Mechanisms and functional significance of aberrant seizure‐induced hippocampal neurogenesisEpilepsia, 49
(1993)
Pathologic substrates of epilepsy
L. Glover, Timothy Schoenfeld, Rose-Marie Karlsson, D. Bannerman, H. Cameron (2017)
Ongoing neurogenesis in the adult dentate gyrus mediates behavioral responses to ambiguous threat cuesPLoS Biology, 15
K. Izumiyama, K. Kogure (1988)
Effect of dihydroergotoxine mesylate (Hydergine®) on delayed neuronal death in the gerbil hippocampusActa Neurologica Scandinavica, 78
Hemal Pathak, F. Weissinger, M. Terunuma, G. Carlson, F. Hsu, S. Moss, D. Coulter (2007)
Disrupted Dentate Granule Cell Chloride Regulation Enhances Synaptic Excitability during Development of Temporal Lobe EpilepsyThe Journal of Neuroscience, 27
Jong Kim, S. Nam, D. Yoo, H. Jung, I. Kim, I. Hwang, J. Seong, Y. Yoon (2017)
Comparison of Adult Hippocampal Neurogenesis and Susceptibility to Treadmill Exercise in Nine Mouse StrainsNeural Plasticity, 2017
Kathleen Mcavoy, Antoine Besnard, Amar Sahay (2015)
Adult hippocampal neurogenesis and pattern separation in DG: a role for feedback inhibition in modulating sparseness to govern population-based codingFrontiers in Systems Neuroscience, 9
U. Heinemann, H. Beck, J. Dreier, E. Ficker, J. Stabel, C. Zhang (1992)
The dentate gyrus as a regulated gate for the propagation of epileptiform activity.Epilepsy research. Supplement, 7
R. Sloviter (1989)
Calcium‐binding protein (calbindin‐D28k) and parvalbumin immunocytochemistry: Localization in the rat hippocampus with specific reference to the selective vulnerability of hippocampal neurons to seizure activityJournal of Comparative Neurology, 280
N. Fountain (2000)
Status Epilepticus: Risk Factors and ComplicationsEpilepsia, 41
Martin Ingvar, P. Morgan, Roland Auer (2004)
The nature and timing of excitotoxic neuronal necrosis in the cerebral cortex, hippocampus and thalamus due to flurothyl-induced status epilepticusActa Neuropathologica, 75
N. Burghardt, Eunhye Park, R. Hen, A. Fenton (2012)
Adult‐born hippocampal neurons promote cognitive flexibility in miceHippocampus, 22
Jason Snyder, N. Kee, J. Wojtowicz (2001)
Effects of adult neurogenesis on synaptic plasticity in the rat dentate gyrus.Journal of neurophysiology, 85 6
J. Noebels, M. Avoli, M. Rogawski, R. Olsen, A. Delgado-Escueta (2012)
Kainate and Temporal Lobe Epilepsies: 3 decades of progress -- Jasper's Basic Mechanisms of the Epilepsies
M. Esposito, Verónica Piatti, D. Laplagne, Nicolás Morgenstern, C. Ferrari, F. Pitossi, A. Schinder (2005)
Neuronal Differentiation in the Adult Hippocampus Recapitulates Embryonic DevelopmentThe Journal of Neuroscience, 25
L. Drew, Stefano Fusi, R. Hen (2013)
Adult neurogenesis in the mammalian hippocampus: Why the dentate gyrus?Learning & Memory, 20
Katherine Jakubs, A. Nanobashvili, S. Bonde, Christine Ekdahl, Z. Kokaia, M. Kokaia, O. Lindvall (2006)
Environment Matters: Synaptic Properties of Neurons Born in the Epileptic Adult Brain Develop to Reduce ExcitabilityNeuron, 52
T. Bush, T. Savidge, T. Freeman, H. Cox, E. Campbell, L. Mucke, Martin Johnson, M. Sofroniew (1998)
Fulminant Jejuno-Ileitis following Ablation of Enteric Glia in Adult Transgenic MiceCell, 93
S. Latchney, Thomas Jaramillo, P. Rivera, A. Eisch, C. Powell (2015)
Chronic P7C3 treatment restores hippocampal neurogenesisNeuroscience Letters, 591
S. Couillard-Després, B. Winner, S. Schaubeck, R. Aigner, M. Vroemen, N. Weidner, U. Bogdahn, J. Winkler, H. Kuhn, L. Aigner (2005)
Doublecortin expression levels in adult brain reflect neurogenesisEuropean Journal of Neuroscience, 21
Xiaoyan Yang, Xuefeng Wang (2015)
Potential mechanisms and clinical applications of mild hypothermia and electroconvulsive therapy on refractory status epilepticusExpert Review of Neurotherapeutics, 15
Yun-Sik Choi, Stanley Lin, Boyoung Lee, P. Kurup, Hee-Yeon Cho, J. Naegele, P. Lombroso, K. Obrietan (2007)
Status Epilepticus-Induced Somatostatinergic Hilar Interneuron Degeneration Is Regulated by Striatal Enriched Protein Tyrosine PhosphataseThe Journal of Neuroscience, 27
Michael Wong (2013)
“TOR”-ing down the Dentate Gate in Temporal Lobe EpilepsyEpilepsy Currents, 13
M. Mazzuferi, G. Kumar, C. Rospo, R. Kaminski (2012)
Rapid epileptogenesis in the mouse pilocarpine model: Video-EEG, pharmacokinetic and histopathological characterizationExperimental Neurology, 238
D. Pollak, F. Monje, L. Zuckerman, C. Denny, M. Drew, E. Kandel (2008)
An Animal Model of a Behavioral Intervention for DepressionNeuron, 60
J. Altman, G. Das (1965)
Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in ratsJournal of Comparative Neurology, 124
S. Ge, Chih-hao Yang, K. Hsu, G. Ming, Hongjun Song (2007)
A Critical Period for Enhanced Synaptic Plasticity in Newly Generated Neurons of the Adult BrainNeuron, 54
C. Stafstrom (2002)
The Incidence and Prevalence of Febrile Seizures
R. Schmidt-Kastner, K. Hossmann (2004)
Distribution of ischemic neuronal damage in the dorsal hippocampus of ratActa Neuropathologica, 76
Jia-min Zhuo, Hua-an Tseng, M. Desai, Mark Bucklin, Ali Mohammed, Nick Robinson, E. Boyden, L. Rangel, A. Jasanoff, H. Gritton, Xue Han (2016)
Young adult born neurons enhance hippocampal dependent performance via influences on bilateral networkseLife, 5
Brian Murphy, R. Pun, H. Yin, Christian Faulkner, Andreas Loepke, S. Danzer (2011)
Heterogeneous Integration of Adult-Generated Granule Cells into the Epileptic BrainThe Journal of Neuroscience, 31
H. Cameron, C. Woolley, B. McEwen, E. Gould (1993)
Differentiation of newly born neurons and glia in the dentate gyrus of the adult ratNeuroscience, 56
David Bonislawski, Elizabeth Schwarzbach, A. Cohen (2007)
Brain injury impairs dentate gyrus inhibitory efficacyNeurobiology of Disease, 25
J. Kleen, Rod Scott, Gregory Holmes, P. Lenck-Santini (2010)
Cognitive and behavioral comorbidities of epilepsyEpilepsia, 51
R. Dingledine, Nicholas Varvel, F. Dudek (2014)
When and how do seizures kill neurons, and is cell death relevant to epileptogenesis?Advances in experimental medicine and biology, 813
James Chen, C. Wasterlain (2006)
Status epilepticus: pathophysiology and management in adultsThe Lancet Neurology, 5
M. Rattka, C. Brandt, W. Löscher (2013)
The intrahippocampal kainate model of temporal lobe epilepsy revisited: Epileptogenesis, behavioral and cognitive alterations, pharmacological response, and hippoccampal damage in epileptic ratsEpilepsy Research, 103
James D’Amour, Alejandra Magagna-Poveda, Jillian Moretto, D. Friedman, J. Lafrancois, Patrice Pearce, A. Fenton, N. MacLusky, H. Scharfman (2015)
Interictal spike frequency varies with ovarian cycle stage in a rat model of epilepsyExperimental Neurology, 269
S. Jessberger, J. Parent (2015)
Epilepsy and Adult Neurogenesis.Cold Spring Harbor perspectives in biology, 7 12
T. Hisatsune (2007)
Adult hippocampal neurogenesisNeuroscience Research, 58
A. Pitkänen, J. Nissinen, J. Nairismägi, K. Lukasiuk, O. Gröhn, R. Miettinen, R. Kauppinen (2002)
Progression of neuronal damage after status epilepticus and during spontaneous seizures in a rat model of temporal lobe epilepsy.Progress in brain research, 135
J. Altman (2011)
Neurogenesis in the adult brain I: Neurobiology, I
H. Cameron, R. McKay (2001)
Adult neurogenesis produces a large pool of new granule cells in the dentate gyrusJournal of Comparative Neurology, 435
Silvio Temprana, L. Mongiat, S. Yang, M. Trinchero, D. Alvarez, E. Kropff, Damiana Giacomini, Natalia Beltramone, G. Lanuza, A. Schinder (2015)
Delayed Coupling to Feedback Inhibition during a Critical Period for the Integration of Adult-Born Granule CellsNeuron, 85
Patrice Pearce, D. Friedman, J. Lafrancois, Sloka Iyengar, A. Fenton, N. MacLusky, H. Scharfman (2014)
Spike–wave discharges in adult Sprague–Dawley rats and their implications for animal models of temporal lobe epilepsyEpilepsy & Behavior, 32
H. Scharfman, C. Myers (2016)
Corruption of the dentate gyrus by “dominant” granule cells: Implications for dentate gyrus function in health and diseaseNeurobiology of Learning and Memory, 129
B. Scott, J. Wojtowicz, W. Burnham (2000)
Neurogenesis in the Dentate Gyrus of the Rat Following Electroconvulsive Shock SeizuresExperimental Neurology, 165
T. Madsen, A. Treschow, J. Bengzon, T. Bolwig, O. Lindvall, A. Tingström (2000)
Increased neurogenesis in a model of electroconvulsive therapyBiological Psychiatry, 47
D. Henshall, B. Meldrum (2012)
Cell death and survival mechanisms after single and repeated brief seizures
Se Choi, Enjana Bylykbashi, Z. Chatila, Star Lee, B. Pulli, G. Clemenson, Eunhee Kim, Alexander Rompala, Mary Oram, Caroline Asselin, Jenna Aronson, C. Zhang, Sean Miller, Andrea Lesinski, John Chen, Doo Kim, H. Praag, B. Spiegelman, F. Gage, R. Tanzi (2018)
Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer’s mouse modelScience, 361
Clay Lacefield, V. Itskov, T. Reardon, R. Hen, J. Gordon (2012)
Effects of adult‐generated granule cells on coordinated network activity in the dentate gyrusHippocampus, 22
匹田 貴夫, 澤本 和延 (2009)
Adult neurogenesis and neural stem cells, 231
S. Kadam, R. D’Ambrosio, V. Duveau, C. Roucard, N. Garcia-Cairasco, A. Ikeda, M. Curtis, A. Galanopoulou, K. Kelly (2017)
Methodological standards and interpretation of video‐electroencephalography in adult control rodents. A TASK1‐WG1 report of the AES/ILAE Translational Task Force of the ILAEEpilepsia, 58
Elena Adlaf, Ryan Vaden, Anastasia Niver, Allison Manuel, Vincent Onyilo, Matheus Araujo, Cristina Dieni, Hai Vo, G. King, Jacques Wadiche, Linda Overstreet-Wadiche (2016)
Adult-born neurons modify excitatory synaptic transmission to existing neuronseLife, 6
N. Sawyer, A. Escayg (2010)
Stress and Epilepsy: Multiple Models, Multiple OutcomesJournal of Clinical Neurophysiology, 27
R. Fisher, H. Scharfman, M. Decurtis (2014)
How can we identify ictal and interictal abnormal activity?Advances in experimental medicine and biology, 813
B. Siesjö, T. Wieloch (1986)
Epileptic brain damage: pathophysiology and neurochemical pathology.Advances in neurology, 44
I. Kazanis (2013)
Neurogenesis in the adult mammalian brain: how much do we need, how much do we have?Current topics in behavioral neurosciences, 15
N. Rensing, D. Guo, M. Wong (2012)
Video-EEG monitoring methods for characterizing rodent models of tuberous sclerosis and epilepsy.Methods in molecular biology, 821
Noora Huusko, Christine Römer, X. Ndode-Ekane, K. Lukasiuk, A. Pitkänen (2013)
Loss of hippocampal interneurons and epileptogenesis: a comparison of two animal models of acquired epilepsyBrain Structure and Function, 220
Marcel Beining, T. Jungenitz, Tijana Radic, T. Deller, Hermann Cuntz, P. Jedlicka, S. Schwarzacher (2016)
Adult-born dentate granule cells show a critical period of dendritic reorganization and are distinct from developmentally born cellsBrain Structure and Function, 222
Rachel Tesla, Hamilton Wolf, P. Xu, J. Drawbridge, S. Estill, Paula Huntington, Latisha McDaniel, Whitney Knobbe, A. Burket, S. Tran, Ruth Starwalt, Lorraine Morlock, Jacinth Naidoo, N. Williams, J. Ready, S. McKnight, A. Pieper (2012)
Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of amyotrophic lateral sclerosisProceedings of the National Academy of Sciences, 109
E. Cavalheiro, N. Santos, M. Priel (1996)
The Pilocarpine Model of Epilepsy in MiceEpilepsia, 37
E. Trinka, R. Kälviäinen (2017)
25 years of advances in the definition, classification and treatment of status epilepticusSeizure, 44
G. Mckhann, H. Wenzel, C. Robbins, A. Sosunov, P. Schwartzkroin (2003)
Mouse strain differences in kainic acid sensitivity, seizure behavior, mortality, and hippocampal pathologyNeuroscience, 122
L. Schmued, Chris Stowers, A. Scallet, Lulu Xu (2005)
Fluoro-Jade C results in ultra high resolution and contrast labeling of degenerating neuronsBrain Research, 1035
M. Lehmkuhle, K. Thomson, P. Scheerlinck, W. Pouliot, Bradley Greger, F. Dudek (2009)
A simple quantitative method for analyzing electrographic status epilepticus in rats.Journal of neurophysiology, 101 3
David Hsu (2007)
The dentate gyrus as a filter or gate: a look back and a look ahead.Progress in brain research, 163
U. Häussler, L. Bielefeld, U. Froriep, Jakob Wolfart, C. Haas (2012)
Septotemporal position in the hippocampal formation determines epileptic and neurogenic activity in temporal lobe epilepsy.Cerebral cortex, 22 1
G. Kempermann (2006)
They Are Not Too Excited: The Possible Role of Adult-Born Neurons in EpilepsyNeuron, 52
M. Saxe, F. Battaglia, Jing-wen Wang, G. Malleret, D. David, J. Monckton, A. Garcia, M. Sofroniew, E. Kandel, L. Santarelli, R. Hen, M. Drew (2006)
Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrusProceedings of the National Academy of Sciences, 103
Meghan Blaya, H. Bramlett, Jacinth Naidoo, A. Pieper, W. Dietrich, Bruce Carter (2014)
Neuroprotective efficacy of a proneurogenic compound after traumatic brain injury.Journal of neurotrauma, 31 5
J. Cavazos, I. Das, T. Sutula (1994)
Neuronal loss induced in limbic pathways by kindling: evidence for induction of hippocampal sclerosis by repeated brief seizures, 14
H. Scharfman, D. McCloskey (2009)
Postnatal neurogenesis as a therapeutic target in temporal lobe epilepsyEpilepsy Research, 85
L. Schmued, K. Hopkins (2000)
Fluoro-Jade B: a high affinity fluorescent marker for the localization of neuronal degenerationBrain Research, 874
Previous studies suggest that reducing the numbers of adult‐born neurons in the dentate gyrus (DG) of the mouse increases susceptibility to severe continuous seizures (status epilepticus; SE) evoked by systemic injection of the convulsant kainic acid (KA). However, it was not clear if the results would be the same for other ways to induce seizures, or if SE‐induced damage would be affected. Therefore, we used pilocarpine, which induces seizures by a different mechanism than KA. Also, we quantified hippocampal damage after SE. In addition, we used both loss‐of‐function and gain‐of‐function methods in adult mice. We hypothesized that after loss‐of‐function, mice would be more susceptible to pilocarpine‐induced SE and SE‐associated hippocampal damage, and after gain‐of‐function, mice would be more protected from SE and hippocampal damage after SE. For loss‐of‐function, adult neurogenesis was suppressed by pharmacogenetic deletion of dividing radial glial precursors. For gain‐of‐function, adult neurogenesis was increased by conditional deletion of pro‐apoptotic gene Bax in Nestin‐expressing progenitors. Fluoro‐Jade C (FJ‐C) was used to quantify neuronal injury and video‐electroencephalography (video‐EEG) was used to quantify SE. Pilocarpine‐induced SE was longer in mice with reduced adult neurogenesis, SE had more power and neuronal damage was greater. Conversely, mice with increased adult‐born neurons had shorter SE, SE had less power, and there was less neuronal damage. The results suggest that adult‐born neurons exert protective effects against SE and SE‐induced neuronal injury.
Hippocampus – Wiley
Published: Aug 1, 2019
Keywords: ; ; ; ;
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.