Access the full text.
Sign up today, get DeepDyve free for 14 days.
K. Kohda, K. Harada, K. Kato, A. Hoshino, J. Motohashi, T. Yamaji, S. Morinobu, N. Matsuoka, Nobumasa Kato (2007)
Glucocorticoid receptor activation is involved in producing abnormal phenotypes of single-prolonged stress rats: A putative post-traumatic stress disorder modelNeuroscience, 148
H. Frielingsdorf, K. Bath, K. Bath, Fatima Soliman, J. Difede, B. Casey, F. Lee (2010)
Variant brain‐derived neurotrophic factor Val66Met endophenotypes: implications for posttraumatic stress disorderAnnals of the New York Academy of Sciences, 1208
A. Karl, M. Schaefer, Loretta Malta, D. Dörfel, N. Rohleder, Annett Werner (2006)
A meta-analysis of structural brain abnormalities in PTSDNeuroscience & Biobehavioral Reviews, 30
B. Elzinga, B. Elzinga, J. Bremner (2002)
Are the neural substrates of memory the final common pathway in posttraumatic stress disorder (PTSD)?Journal of affective disorders, 70 1
S. Kirov, K. Harris (1999)
Dendrites are more spiny on mature hippocampal neurons when synapses are inactivatedNature Neuroscience, 2
E. Moser, K. Krobert, M. Moser, R. Morris (1998)
Impaired spatial learning after saturation of long-term potentiation.Science, 281 5385
Wajeeha Aziz, Wen Wang, S. Kesaf, Alsayed Mohamed, Y. Fukazawa, R. Shigemoto (2013)
Distinct kinetics of synaptic structural plasticity, memory formation, and memory decay in massed and spaced learningProceedings of the National Academy of Sciences, 111
Kristin Arendt, Federica Sarti, Lu Chen (2013)
Chronic Inactivation of a Neural Circuit Enhances LTP by Inducing Silent Synapse FormationThe Journal of Neuroscience, 33
H. Kasai, M. Matsuzaki, J. Noguchi, N. Yasumatsu, H. Nakahara (2003)
Structure–stability–function relationships of dendritic spinesTrends in Neurosciences, 26
S. Martin, R. Morris (2002)
New life in an old idea: The synaptic plasticity and memory hypothesis revisitedHippocampus, 12
Larissa Rizhova, B. Klementiev, Karine Cambon, C. Venero, Carmen Sandi, Elena Vershinina, Elisabetta Vaudano, V. Berezin, Elisabeth Bock (2007)
Effects of P2, a peptide derived from a homophilic binding site in the neural cell adhesion molecule on learning and memory in ratsNeuroscience, 149
T. Lee, J. Saruta, K. Sasaguri, S. Sato, K. Tsukinoki (2008)
Allowing animals to bite reverses the effects of immobilization stress on hippocampal neurotrophin expressionBrain Research, 1195
C. Márquez, X. Belda, A. Armario (2002)
Post-stress recovery of pituitary–adrenal hormones and glucose, but not the response during exposure to the stressor, is a marker of stress intensity in highly stressful situationsBrain Research, 926
K. Uluc, P. Kendigelen, Emin Fidan, Louise Zhang, Vishal Chanana, D. Kintner, E. Akture, Chihwa Song, K. Ye, Dandan Sun, P. Ferrazzano, P. Cengiz (2013)
TrkB receptor agonist 7, 8 dihydroxyflavone triggers profound gender- dependent neuroprotection in mice after perinatal hypoxia and ischemia.CNS & neurological disorders drug targets, 12 3
N. Sousa, M. Madeira, M. Paula-Barbosa (1998)
Effects of corticosterone treatment and rehabilitation on the hippocampal formation of neonatal and adult rats. An unbiased stereological studyBrain Research, 794
G. Molenberghs (2010)
Generalized Estimating EquationsMethods of Information in Medicine, 49
Mark Smith, Shinya Makino, R. Kvetňanský, Robert Post, Psy-Chiatry Branch (1995)
Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus, 15
A. Blugeot, C. Rivat, E. Bouvier, J. Molet, Amandine Mouchard, B. Zeau, C. Bernard, J. Benoliel, C. Becker (2011)
Vulnerability to Depression: From Brain Neuroplasticity to Identification of BiomarkersThe Journal of Neuroscience, 31
X. Belda, S. Fuentes, R. Nadal, A. Armario (2008)
A single exposure to immobilization causes long-lasting pituitary-adrenal and behavioral sensitization to mild stressorsHormones and Behavior, 54
R. Andero, S. Heldt, K. Ye, Xia Liu, A. Armario, K. Ressler (2011)
Effect of 7,8-dihydroxyflavone, a small-molecule TrkB agonist, on emotional learning.The American journal of psychiatry, 168 2
R. Sapolsky, L. Romero, A. Munck (2000)
How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions.Endocrine reviews, 21 1
T. Ueyama, Y. Kawai, K. Nemoto, M. Sekimoto, S. Toné, E. Senba (1997)
Immobilization stress reduced the expression of neurotrophins and their receptors in the rat brainNeuroscience Research, 28
Shuji Murakami, H. Imbe, Y. Morikawa, C. Kubo, E. Senba (2005)
Chronic stress, as well as acute stress, reduces BDNF mRNA expression in the rat hippocampus but less robustlyNeuroscience Research, 53
L. Dell’Osso, C. Carmassi, A. Debbio, M. Dell’Osso, C. Bianchi, E. Pozzo, N. Origlia, L. Domenici, G. Massimetti, D. Marazziti, A. Piccinni (2009)
Brain-derived neurotrophic factor plasma levels in patients suffering from post-traumatic stress disorderProgress in Neuro-Psychopharmacology and Biological Psychiatry, 33
T. Numakawa, N. Adachi, Misty Richards, S. Chiba, H. Kunugi (2013)
Brain-derived neurotrophic factor and glucocorticoids: Reciprocal influence on the central nervous systemNeuroscience, 239
L. Devi, M. Ohno (2012)
7,8-Dihydroxyflavone, a Small-Molecule TrkB Agonist, Reverses Memory Deficits and BACE1 Elevation in a Mouse Model of Alzheimer's DiseaseNeuropsychopharmacology, 37
Sung-Wuk Jang, Xia Liu, M. Yepes, K. Shepherd, G. Miller, Yang Liu, W. Wilson, Ge Xiao, B. Blanchi, Y. Sun, K. Ye, Solomon Snyder, Johns Hopkins, S.-W J (2010)
A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavoneProceedings of the National Academy of Sciences, 107
A. Armario, Núria Daviu, Cristina Muñoz-Abellán, Cristina Rabasa, S. Fuentes, X. Belda, H. Gagliano, R. Nadal (2012)
What can We Know from Pituitary–Adrenal Hormones About the Nature and Consequences of Exposure to Emotional Stressors?Cellular and Molecular Neurobiology, 32
A. Armario, R. Escorihuela, R. Nadal (2008)
Long-term neuroendocrine and behavioural effects of a single exposure to stress in adult animalsNeuroscience & Biobehavioral Reviews, 32
Yuan-jian Yang, Yan-kun Li, Wei Wang, Jianbo Wan, Bin Yu, Meiyan Wang, Bin Hu (2014)
Small-molecule TrkB agonist 7,8-dihydroxyflavone reverses cognitive and synaptic plasticity deficits in a rat model of schizophreniaPharmacology Biochemistry and Behavior, 122
S. Hauck, F. Kapczinski, R. Roesler, É. Silveira, P. Magalhães, Letícia Kruel, S. Schestatsky, L. Ceitlin (2010)
Serum brain-derived neurotrophic factor in patients with trauma psychopathologyProgress in Neuro-Psychopharmacology and Biological Psychiatry, 34
Victor Pineda, J. Athos, Hongbing Wang, Jeremy Celver, D. Ippolito, G. Boulay, L. Birnbaumer, D. Storm (2004)
Removal of Giα1 Constraints on Adenylyl Cyclase in the Hippocampus Enhances LTP and Impairs Memory FormationNeuron, 41
F. Jeanneteau, M. Chao (2013)
Are BDNF and glucocorticoid activities calibrated?Neuroscience, 239
P. Adlard, C. Cotman (2004)
Voluntary exercise protects against stress-induced decreases in brain-derived neurotrophic factor protein expressionNeuroscience, 124
O. Martı́, Arantxa García, Astrid Vellès, M. Harbuz, Antonio Armario (2001)
Evidence that a single exposure to aversive stimuli triggers long-lasting effects in the hypothalamus-pituitary-adrenal axis that consolidate with time.The European journal of neuroscience, 13 1
G. Kerchner, R. Nicoll (2008)
Silent synapses and the emergence of a postsynaptic mechanism for LTPNature Reviews Neuroscience, 9
R. Andero, K. Ressler, K. Ressler (2012)
Fear extinction and BDNF: translating animal models of PTSD to the clinicGenes, 11
T. Steckler, V. Risbrough (2012)
Pharmacological treatment of PTSD – Established and new approachesNeuropharmacology, 62
Gary Philips, Xiaojing Ye, Ashley Kopec, T. Carew (2013)
MAPK Establishes a Molecular Context That Defines Effective Training Patterns for Long-Term Memory FormationThe Journal of Neuroscience, 33
H. Gagliano, S. Fuentes, R. Nadal, A. Armario (2008)
Previous exposure to immobilisation and repeated exposure to a novel environment demonstrate a marked dissociation between behavioral and pituitary–adrenal responsesBehavioural Brain Research, 187
R. Pitman, A. Rasmusson, K. Koenen, L. Shin, S. Orr, M. Gilbertson, M. Milad, I. Liberzon (2012)
Biological studies of post-traumatic stress disorderNature Reviews Neuroscience, 13
Marion Benoist, Rocío Palenzuela, C. Rozas, P. Rojas, Elena Tortosa, B. Morales, C. González-Billault, J. Ávila, J. Esteban (2013)
MAP1B‐dependent Rac activation is required for AMPA receptor endocytosis during long‐term depressionThe EMBO Journal, 32
K. Hughes, L. Shin (2011)
Functional neuroimaging studies of post-traumatic stress disorderExpert Review of Neurotherapeutics, 11
M. Gilbertson, M. Shenton, A. Ciszewski, K. Kasai, N. Lasko, S. Orr, R. Pitman (2002)
Smaller hippocampal volume predicts pathologic vulnerability to psychological traumaNature Neuroscience, 5
Michael Smith (2005)
Bilateral hippocampal volume reduction in adults with post‐traumatic stress disorder: A meta‐analysis of structural MRI studiesHippocampus, 15
R. Andero, Núria Daviu, R. Escorihuela, R. Nadal, A. Armario (2012)
7,8‐dihydroxyflavone, a TrkB receptor agonist, blocks long‐term spatial memory impairment caused by immobilization stress in ratsHippocampus, 22
W. Berger, Akhil Mehra, M. Lenoci, T. Metzler, C. Otte, G. Tarasovsky, S. Mellon, O. Wolkowitz, C. Marmar, T. Neylan (2010)
Serum brain-derived neurotrophic factor predicts responses to escitalopram in chronic posttraumatic stress disorderProgress in Neuro-Psychopharmacology and Biological Psychiatry, 34
M. Tress (2003)
Generalized, Linear, and Mixed ModelsTechnometrics, 45
J. Chen, Kao‐Wei Chua, C. Chua, Hailong Yu, Aijie Pei, B. Chua, R. Hamdy, Xingshun Xu, Chun-feng Liu (2011)
Antioxidant activity of 7,8-dihydroxyflavone provides neuroprotection against glutamate-induced toxicityNeuroscience Letters, 499
Y. Golub, S. Kaltwasser, C. Mauch, L. Herrmann, U. Schmidt, F. Holsboer, M. Czisch, C. Wotjak (2011)
Reduced hippocampus volume in the mouse model of Posttraumatic Stress Disorder.Journal of psychiatric research, 45 5
D. Diamond, Adam Campbell, Collin Park, Joshua Halonen, P. Zoladz (2007)
The Temporal Dynamics Model of Emotional Memory Processing: A Synthesis on the Neurobiological Basis of Stress-Induced Amnesia, Flashbulb and Traumatic Memories, and the Yerkes-Dodson LawNeural Plasticity, 2007
Post‐traumatic stress disorder (PTSD) occurs after exposure to traumatic situations and it is characterized by cognitive deficits that include impaired explicit memory. The neurobiological bases of such PTSD‐associated memory alterations are yet to be elucidated and no satisfactory treatment for them exists. To address this issue, we first studied whether a single exposure of young adult rats (60 days) to immobilization on boards (IMO), a putative model of PTSD, produces long‐term behavioral effects (2–8 days) similar to those found in PTSD patients. Subsequently, we investigated whether the administration of the TrkB agonist 7,8‐dihydroxyflavone (DHF) 8 h after stress (therapeutic window) ameliorated the PTSD‐like effect of IMO and the associated changes in synaptic plasticity. A single IMO exposure induced a spatial memory impairment similar to that found in other animal models of PTSD or in PTSD patients. IMO also increased spine density and long‐term potentiation (LTP) in the CA3‐CA1 pathway. Significantly, DHF reverted both spatial memory impairment and the increase in LTP, while it produced no effect in the controls. These data provide novel insights into the possible neurobiological substrate for explicit memory impairment in PTSD patients, supporting the idea that the activation of the BDNF/TrkB pathway fulfils a protective role after severe stress. Administration of DHF in the aftermath of a traumatic experience might be relevant to prevent its long‐term consequences. © 2016 Wiley Periodicals, Inc.
Hippocampus – Wiley
Published: Sep 1, 2016
Keywords: ; ; ; ; ;
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.