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Adenosine deaminase polymorphism in man

Adenosine deaminase polymorphism in man Summary 1 A new and specific method for the study of adenosine deaminase isozymes is described. 2 Examination of red‐cell lysates has revealed three genetically determined electrophoretically different ADA phenotypes: ADA 1, ADA 2–1 and ADA 2. 3 Family studies indicate that these phenotypes are determined by two alleles, ADA1 and ADA2 at an autosomal locus. 4 Preliminary population data suggest that ADA2 has a frequency of about 0.06 in European, 0.04 in Negroes and 0.11 in Asiatic Indians. 5 The behaviour of the ADA isozyme pattern on storage or after treatment with thiol reagents suggests the occurrence of reactive sulphydryl groups in the enzyme molecules. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Human Genetics Wiley

Adenosine deaminase polymorphism in man

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References (5)

Publisher
Wiley
Copyright
Copyright © 1968 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0003-4800
eISSN
1469-1809
DOI
10.1111/j.1469-1809.1968.tb00044.x
Publisher site
See Article on Publisher Site

Abstract

Summary 1 A new and specific method for the study of adenosine deaminase isozymes is described. 2 Examination of red‐cell lysates has revealed three genetically determined electrophoretically different ADA phenotypes: ADA 1, ADA 2–1 and ADA 2. 3 Family studies indicate that these phenotypes are determined by two alleles, ADA1 and ADA2 at an autosomal locus. 4 Preliminary population data suggest that ADA2 has a frequency of about 0.06 in European, 0.04 in Negroes and 0.11 in Asiatic Indians. 5 The behaviour of the ADA isozyme pattern on storage or after treatment with thiol reagents suggests the occurrence of reactive sulphydryl groups in the enzyme molecules.

Journal

Annals of Human GeneticsWiley

Published: Jul 1, 1968

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