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Acid‐Catalyzed Pseudo Five‐Component Annulation for a General One‐Pot Synthesis of 2,4,6‐Triaryl Pyrimidines

Acid‐Catalyzed Pseudo Five‐Component Annulation for a General One‐Pot Synthesis of 2,4,6‐Triaryl... A facile and general synthesis of 2,4,6‐triaryl pyrimidines has been developed. It involves a one‐pot [2+1+1+1+1] pseudo five‐component annulation of one methyl ketone, two aldehydes and two NH4OAc catalyzed by TfOH. One C−C and four C−N bonds are formed during the oxidative annulation process. The reaction shows good tolerance of many important functional groups in air and produces only water as the coproduct, making this methodology a highly versatile alternative to the existing methods for structuring pyrimidine framework. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Asian Journal of Organic Chemistry Wiley

Acid‐Catalyzed Pseudo Five‐Component Annulation for a General One‐Pot Synthesis of 2,4,6‐Triaryl Pyrimidines

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References (61)

Publisher
Wiley
Copyright
© 2020 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim
ISSN
2193-5807
eISSN
2193-5815
DOI
10.1002/ajoc.201900700
Publisher site
See Article on Publisher Site

Abstract

A facile and general synthesis of 2,4,6‐triaryl pyrimidines has been developed. It involves a one‐pot [2+1+1+1+1] pseudo five‐component annulation of one methyl ketone, two aldehydes and two NH4OAc catalyzed by TfOH. One C−C and four C−N bonds are formed during the oxidative annulation process. The reaction shows good tolerance of many important functional groups in air and produces only water as the coproduct, making this methodology a highly versatile alternative to the existing methods for structuring pyrimidine framework.

Journal

Asian Journal of Organic ChemistryWiley

Published: Feb 1, 2020

Keywords: ; ; ; ;

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