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ABO frequencies in mongolism *

ABO frequencies in mongolism * Summary The ABO blood types of 581 institutionalized mongoloid subjects were determined and compared with blood types of a like number of non‐mongoloid retardates drawn from the same institutions. No significant differences in counties of residence of the two groups were detected. Comparison of the ABO frequencies revealed a slight deficiency of types O and B and a comparable excess of types A and AB among mongoloids, but the differences do not reach conventiond significance levels. Theoretical considerations indicate that the data neither support nor controvert the hypothesis of linkage of the ABO locus to chromosome 21, and that linkage of any locus exhibiting complete dominance will be difficult to establish using population gene frequency analyses, unleea the locus is absolutely linked to the kinetochore and trisomics arise largely or solely through fist meiotic division non‐disjunction. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Human Genetics Wiley

ABO frequencies in mongolism *

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References (12)

Publisher
Wiley
Copyright
Copyright © 1966 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0003-4800
eISSN
1469-1809
DOI
10.1111/j.1469-1809.1966.tb00005.x
Publisher site
See Article on Publisher Site

Abstract

Summary The ABO blood types of 581 institutionalized mongoloid subjects were determined and compared with blood types of a like number of non‐mongoloid retardates drawn from the same institutions. No significant differences in counties of residence of the two groups were detected. Comparison of the ABO frequencies revealed a slight deficiency of types O and B and a comparable excess of types A and AB among mongoloids, but the differences do not reach conventiond significance levels. Theoretical considerations indicate that the data neither support nor controvert the hypothesis of linkage of the ABO locus to chromosome 21, and that linkage of any locus exhibiting complete dominance will be difficult to establish using population gene frequency analyses, unleea the locus is absolutely linked to the kinetochore and trisomics arise largely or solely through fist meiotic division non‐disjunction.

Journal

Annals of Human GeneticsWiley

Published: Jul 1, 1966

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