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Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer‐related deaths in the United States, making it a major public health concern.1 Surgical resection is the only potentially curative treatment for PDAC. Approximately half of the patients with PDAC present with metastatic diseases, most commonly with liver metastases.2,3 In these patients, the detection and accurate diagnosis of liver metastases are crucial because their presence results in substantial changes in the treatment strategy.4 The National Comprehensive Cancer Network guidelines recommend dynamic contrast‐enhanced computed tomography (CECT) as the preferred imaging modality for the initial evaluation of local resectability and detection of metastases in patients with PDAC.4 Endoscopic ultrasonography and endoscopic retrograde cholangiopancreatography are subsequently performed to confirm the diagnosis. Magnetic resonance imaging (MRI) is not routinely used for staging mainly because of the limited throughput and its limited availability.4Gadoxetic acid‐enhanced MRI enables the acquisition of hepatobiliary phase (HBP) images and has been reported to be useful in detecting liver metastases in patients with PDAC, with better sensitivity than that of CECT.5,6 However, the long examination time may limit the use of gadoxetic acid‐enhanced MRI for patients with PDAC. Abbreviated MRI protocols with limited sequences, which can theoretically be performed in
Journal of Magnetic Resonance Imaging – Wiley
Published: Sep 1, 2022
Keywords: pancreatic adenocarcinoma; liver metastases; MRI; gadoxetic acid
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