Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

A STATISTICAL NOTE CONCERNING CELL‐COUNT VARIATION BETWEEN OBSERVERS, AND BETWEEN CULTURES FROM BLOOD SAMPLES TAKEN AT DIFFERENT TIMES FROM ONE INDIVIDUAL

A STATISTICAL NOTE CONCERNING CELL‐COUNT VARIATION BETWEEN OBSERVERS, AND BETWEEN CULTURES FROM... BY H. GOLDSTEIN Department of Statistics, University College London An experiment was designed in order to test for differences in the proportions of non-modal and abnormal cells counted, between different observers and between cultures taken a t different times from the same individual. The experiment involved six observers in the M.R.C. Clinical Effects of Radiation Research Unit and three leucocyte cultures from samples taken a t weekly intervals from a 61-year-old woman. Two slides were made from each culture in the usual way in preparation for chromosome analysis. The slides were examined a t the same time, every observer analysing thirty cells on each slide and the slides taken in rotation to eliminate order effects. The design is a 6 x 3 cross-classificationwith one replication (the second slide from the same culture). It was decided to carry out the analysis on the number of A and B type cells containing 45 chromosomes (modal number 46) out of the total number of cells counted on a slide, and also on the number of C-type cells out of the total. One of the slides was found to be too poor to be included in the analysis. A. The results for http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Human Genetics Wiley

A STATISTICAL NOTE CONCERNING CELL‐COUNT VARIATION BETWEEN OBSERVERS, AND BETWEEN CULTURES FROM BLOOD SAMPLES TAKEN AT DIFFERENT TIMES FROM ONE INDIVIDUAL

Goldstein, H.
Annals of Human Genetics , Volume 27 (4) – Jun 1, 1963
Download PDF
3 pages

Loading next page...
 
/lp/wiley/a-statistical-note-concerning-cell-count-variation-between-observers-GCbGsoIfdJ

References (1)

Publisher
Wiley
Copyright
Copyright © 1963 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0003-4800
eISSN
1469-1809
DOI
10.1111/j.1469-1809.1963.tb01533.x
Publisher site
See Article on Publisher Site

Abstract

BY H. GOLDSTEIN Department of Statistics, University College London An experiment was designed in order to test for differences in the proportions of non-modal and abnormal cells counted, between different observers and between cultures taken a t different times from the same individual. The experiment involved six observers in the M.R.C. Clinical Effects of Radiation Research Unit and three leucocyte cultures from samples taken a t weekly intervals from a 61-year-old woman. Two slides were made from each culture in the usual way in preparation for chromosome analysis. The slides were examined a t the same time, every observer analysing thirty cells on each slide and the slides taken in rotation to eliminate order effects. The design is a 6 x 3 cross-classificationwith one replication (the second slide from the same culture). It was decided to carry out the analysis on the number of A and B type cells containing 45 chromosomes (modal number 46) out of the total number of cells counted on a slide, and also on the number of C-type cells out of the total. One of the slides was found to be too poor to be included in the analysis. A. The results for

Journal

Annals of Human Genetics – Wiley

Published: Jun 1, 1963

There are no references for this article.