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M. Atkinson, A. Murray (1965)
INHIBITION OF PRUINE PHOSPHORIBOSYLTRANSFERASES OF EHRLICH ASCITES-TUMOUR CELLS BY 6-MERCAPTOPURINE.The Biochemical journal, 94
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The gel-filtration behaviour of proteins related to their molecular weights over a wide range.The Biochemical journal, 96 3
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Purification and kinetic studies of adenine phosphoribosyltransferase from human erythrocytes.Archives of biochemistry and biophysics, 142 2
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An electrophoretic method for EDWARDS
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Protein Ineasuromrrit with thr
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Thermostability studies on tho isozyines o f
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Molecular size estimates of human peptidases determinrd by separnt
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Human lymphoblastoid cell lines. 1. Culture methods and examination for Epstein‐Barr virus.J. Natn. Cancer Inst., 47
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Thermostability studies on the isozymes of human phosphoglucomutaseAnnals of Human Genetics, 34
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Inhibition of purinc phosphoribosyl transferases
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Molecular size estimates of human peptidases determinrd by separnt,cL
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Inhcrited variants of human nucleoside phos - I 1 H G E ~ ~ range
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39, 745. phosphoribosyl transferase deficiency. A previously undescribed genetic defect in man. J . C'lin.. Invest. 47, 2281. defect in gout associntod with over-production of uric ncid
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[Chronic obliterating arteriopathies in Honduras. Statistical analysis of 183 cases].Angiologia, 20 2
W. Lewis, H. Harris (1969)
Molecular size estimates of human peptidases determined by separate gene lociAnnals of Human Genetics, 33
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The separation of adenine and hypoxanthine-guanine phosphoribosyl BOWMAN
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Purification and kinetic studies of adenine phosphoribosyl-trailsfcruse STEEL
Printed in Great Brituin A search for electrophoretic variants of human adenine phosphoribosyl transferase BY SUSAN MOWBRAY, B. WATSON AND HARRY HARRIS H . R .C. Human Biochemical Genetics Unit, The Galton Laboratorg, University College London Adenine phosphoribosyl transferase (APRT) catalyses the reaction of adenine with 5-pliosphoribosyl-pyrophosphate to give adenosine-5â-monophosphate and pyrophosphate. It is widely distributed in human tissues. There have been several reports of inherited variation of APRT in man. Kelley et nl. (1968) described a family in which four individuals showed a partial deficiency of the enzyme activity in red cells. The trait appeared to be inherited as an autosomal heterozygous character, and it did not appear to be associated with any obvious abnormality in uric acid production. Henderson et al. ( 1968) reported individual differences in therniostability of red cell APRT, which appeared to represent a common polymorphism involving two alleles, one produciiig a relatively more unstable form of the enzyme than the other. Bakay & Nyhan (1971) described the electrophoresis of APRT in acrylamide gels and reported that usually the enzyme migrated as a single symmetrical zone of activity, and in one individual a faster migrating variant was observed. I n the present paper
Annals of Human Genetics – Wiley
Published: Nov 1, 1972
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