Access the full text.
Sign up today, get DeepDyve free for 14 days.
T. Aguado, E. Romero, K. Monory, J. Palazuelos, M. Sendtner, G. Marsicano, B. Lutz, M. Guzmán, I. Galve-Roperh (2007)
The CB1 Cannabinoid Receptor Mediates Excitotoxicity-induced Neural Progenitor Proliferation and Neurogenesis*Journal of Biological Chemistry, 282
M. Uda, M. Ishido, K. Kami, M. Masuhara (2006)
Effects of chronic treadmill running on neurogenesis in the dentate gyrus of the hippocampus of adult ratBrain Research, 1104
L. Matsuda, S. Lolait, M. Brownstein, A. Young, T. Bonner (1990)
Structure of a cannabinoid receptor and functional expression of the cloned cDNANature, 346
Andrea Olson, B. Eadie, C. Ernst, B. Christie (2006)
Environmental enrichment and voluntary exercise massively increase neurogenesis in the adult hippocampus via dissociable pathwaysHippocampus, 16
S. Neeper, F. Gomez-Pinilla, James Choi, C. Cotman (1996)
Physical activity increases mRNA for brain-derived neurotrophic factor and nerve growth factor in rat brainBrain Research, 726
Hyungju Park, M. Poo (2012)
Neurotrophin regulation of neural circuit development and functionNature Reviews Neuroscience, 14
R. Mitra, K. Sundlass, K. Parker, A. Schatzberg, D. Lyons (2006)
Social stress-related behavior affects hippocampal cell proliferation in micePhysiology & Behavior, 89
Sarah Dubreucq, M. Koehl, D. Abrous, G. Marsicano, F. Chaouloff (2010)
CB1 receptor deficiency decreases wheel-running activity: Consequences on emotional behaviours and hippocampal neurogenesisExperimental Neurology, 224
L. Sim‐Selley, Nicole Schechter, W. Rorrer, George Dalton, J. Hernandez, Billy Martin, D. Selley (2006)
Prolonged Recovery Rate of CB1 Receptor Adaptation after Cessation of Long-Term Cannabinoid AdministrationMolecular Pharmacology, 70
L. Wise, J. Harloe, A. Lichtman (2009)
Fatty acid amide hydrolase (FAAH) knockout mice exhibit enhanced acquisition of an aversive, but not of an appetitive, Barnes maze taskNeurobiology of Learning and Memory, 92
Yeunhee Kim, Hyun-Bae Kim, Mi-Hyeon Jang, Baek-Vin Lim, Youn-Jung Kim, Hong Kim, Sung-Soo Kim, Ee-Hwa Kim, Chang-Ju Kim (2003)
Magnitude- and time-dependence of the effect of treadmill exercise on cell proliferation in the dentate gyrus of rats.International journal of sports medicine, 24 2
V. Marzo, M. Bifulco, L. Petrocellis (2004)
The endocannabinoid system and its therapeutic exploitationNature Reviews Drug Discovery, 3
W. Devane, L. Hanuš, A. Breuer, R. Pertwee, L. Stevenson, G. Griffin, D. Gibson, A. Mandelbaum, A. Etinger, R. Mechoulam (1992)
Isolation and structure of a brain constituent that binds to the cannabinoid receptor.Science, 258 5090
E. Marco, T. Rubino, W. Adriani, Maria-Paz Viveros, D. Parolaro, G. Laviola (2009)
Long-term consequences of URB597 administration during adolescence on cannabinoid CB1 receptor binding in brain areasBrain Research, 1257
E. Heyman, E. Heyman, F. Gamelin, Maaike Goekint, F. Piscitelli, B. Roelands, E. Leclair, V. Marzo, R. Meeusen (2012)
Intense exercise increases circulating endocannabinoid and BDNF levels in humans—Possible implications for reward and depressionPsychoneuroendocrinology, 37
C. Lundmark (2005)
A Hitchhiker's Guide to…, 55
edro Bekinschteina, Charlotte Oomena, Lisa Saksidaa, Timothy Busseya (2011)
ffects of environmental enrichment and voluntary exercise on neurogenesis , earning and memory , and pattern separation : BDNF as a critical variable ?
E. Aso, A. Ozaita, E. Valdizán, C. Ledent, Á. Pazos, R. Maldonado, O. Valverde (2008)
BDNF impairment in the hippocampus is related to enhanced despair behavior in CB1 knockout miceJournal of Neurochemistry, 105
F. Moreira, Nadine Kaiser, K. Monory, B. Lutz (2008)
Reduced anxiety-like behaviour induced by genetic and pharmacological inhibition of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) is mediated by CB1 receptorsNeuropharmacology, 54
Hui-li Liu, Gang Zhao, Kui Cai, Hai-hua Zhao, Li-de Shi (2011)
Treadmill exercise prevents decline in spatial learning and memory in APP/PS1 transgenic mice through improvement of hippocampal long-term potentiationBehavioural Brain Research, 218
R. Lister (2004)
The use of a plus-maze to measure anxiety in the mousePsychopharmacology, 92
R. Mechoulam, S. Ben-Shabat, L. Hanuš, M. Ligumsky, N. Kaminski, A. Schatz, A. Gopher, S. Almog, B. Martin, D. Compton, R. Pertwee, G. Griffin, M. Bayewitch, J. Barg, Z. Vogel (1995)
Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors.Biochemical pharmacology, 50 1
Sachin Patel, C. Hillard (2006)
Pharmacological Evaluation of Cannabinoid Receptor Ligands in a Mouse Model of Anxiety: Further Evidence for an Anxiolytic Role for Endogenous Cannabinoid SignalingJournal of Pharmacology and Experimental Therapeutics, 318
Thiago Lazaroni, A. Raslan, Walkíria Fontes, M. Oliveira, M. Bader, N. Alenina, M. Moraes, R. Santos, G. Pereira (2012)
Angiotensin-(1–7)/Mas axis integrity is required for the expression of object recognition memoryNeurobiology of Learning and Memory, 97
C. Hillman, K. Erickson, A. Kramer (2008)
Be smart, exercise your heart: exercise effects on brain and cognitionNature Reviews Neuroscience, 9
T. Aguado, K. Monory, J. Palazuelos, Nephi Stella‡, Benjamin Cravatt, Beat Lutz, Giovanni Marsicano, Z. Kokaia, Manuel Guzmán, I. Galve-Roperh (2005)
The endocannabinoid system drives neural progenitor proliferationThe FASEB Journal, 19
N. Madroñal, A. Gruart, O. Valverde, Isabel Espadas, R. Moratalla, J. Delgado-García (2012)
Involvement of cannabinoid CB1 receptor in associative learning and in hippocampal CA3-CA1 synaptic plasticity.Cerebral cortex, 22 3
A. Lichtman, K. Dimen, Billy Martin (1995)
Systemic or intrahippocampal cannabinoid administration impairs spatial memory in ratsPsychopharmacology, 119
C. Mazzola, J. Medalie, M. Scherma, L. Panlilio, M. Solinas, G. Tanda, F. Drago, J. Cadet, S. Goldberg, S. Yasar (2009)
Fatty acid amide hydrolase (FAAH) inhibition enhances memory acquisition through activation of PPAR-alpha nuclear receptors.Learning & memory, 16 5
V. Marzo (2008)
Targeting the endocannabinoid system: to enhance or reduce?Nature Reviews Drug Discovery, 7
E. Butovsky, A. Juknat, I. Goncharov, J. Elbaz, R. Eilam, A. Zangen, Z. Vogel (2005)
In vivo up‐regulation of brain‐derived neurotrophic factor in specific brain areas by chronic exposure to Δ9‐tetrahydrocannabinolJournal of Neurochemistry, 93
Kenichi Suijo, S. Inoue, Y. Ohya, Y. Odagiri, T. Takamiya, Hiroko Ishibashi, M. Itoh, Y. Fujieda, T. Shimomitsu (2012)
Resistance Exercise Enhances Cognitive Function in MouseInternational Journal of Sports Medicine, 34
Sandra Zoubovsky, V. Pogorelov, Y. Taniguchi, Sun-Hong Kim, P. Yoon, E. Nwulia, A. Sawa, M. Pletnikov, A. Kamiya (2011)
Working memory deficits in neuronal nitric oxide synthase knockout mice: potential impairments in prefrontal cortex mediated cognitive function.Biochemical and biophysical research communications, 408 4
R. Galani, I. Weiss, J. Cassel, C. Kelche (1998)
Spatial memory, habituation, and reactions to spatial and nonspatial changes in rats with selective lesions of the hippocampus, the entorhinal cortex or the subiculumBehavioural Brain Research, 96
Vincenzo Marzo (2009)
The endocannabinoid system: its general strategy of action, tools for its pharmacological manipulation and potential therapeutic exploitation.Pharmacological research, 60 2
S. Varvel, L. Wise, F. Niyuhire, B. Cravatt, A. Lichtman (2007)
Inhibition of Fatty-Acid Amide Hydrolase Accelerates Acquisition and Extinction Rates in a Spatial Memory TaskNeuropsychopharmacology, 32
T. Bisogno, A. Ligresti, V. Marzo (2005)
The endocannabinoid signalling system: Biochemical aspectsPharmacology Biochemistry and Behavior, 81
Nuno Sousa, O. Almeida, Carsten Wotjak (2006)
A hitchhiker's guide to behavioral analysis in laboratory rodentsGenes, 5
E. Fuchs, G. Flügge (1998)
Stress, glucocorticoids and structural plasticity of the hippocampusNeuroscience & Biobehavioral Reviews, 23
Kevin Baker, J. Kim (2002)
Effects of stress and hippocampal NMDA receptor antagonism on recognition memory in rats.Learning & memory, 9 2
M. Hill, A. Titterness, Anna Morrish, E. Carrier, Tiffany Lee, J. Gil-Mohapel, B. Gorzalka, C. Hillard, B. Christie (2009)
Endogenous cannabinoid signaling is required for voluntary exercise‐induced enhancement of progenitor cell proliferation in the hippocampusHippocampus, 20
P. Sparling, A. Giuffrida, D. Piomelli, L. Rosskopf, Arne Dietrich (2003)
Exercise activates the endocannabinoid systemNeuroReport, 14
Sérgio Silva, B. Araujo, A. Cossa, F. Scorza, E. Cavalheiro, M. Naffah-Mazzacoratti, R. Arida (2010)
Physical exercise in adolescence changes CB1 cannabinoid receptor expression in the rat brainNeurochemistry International, 57
D. Piomelli (2003)
The molecular logic of endocannabinoid signallingNature Reviews Neuroscience, 4
H. Praag, G. Kempermann, F. Gage (2000)
Neural consequences of enviromental enrichmentNature Reviews Neuroscience, 1
Rebecca Johnson, Justin Rhodes, S. Jeffrey, T. Garland, Gordon Mitchell (2003)
Hippocampal brain-derived neurotrophic factor but not neurotrophin-3 increases more in mice selected for increased voluntary wheel runningNeuroscience, 121
J. Romero, F. Berrendero, J. Manzanares, Alberto Pérez, J. Corchero, J. Fuentes, J. Fernández-Ruiz, J. Ramos (1998)
Time‐course of the cannabinoid receptor down‐regulation in the adult rat brain caused by repeated exposure to Δ9‐tetrahydrocannabinolSynapse, 30
L. Suarez, E. Cid, B. Gal, M. Inostroza, J. Brotons-Mas, Daniel Gomez-Dominguez, L. Prida, J. Solís (2012)
Systemic Injection of Kainic Acid Differently Affects LTP Magnitude Depending on its Epileptogenic EfficiencyPLoS ONE, 7
S. Munro, K. Thomas, Muna Abu-Shaar (1993)
Molecular characterization of a peripheral receptor for cannabinoidsNature, 365
Toshiko Suenaga, Masami Kaku, Y. Ichitani (2008)
Effects of intrahippocampal cannabinoid receptor agonist and antagonist on radial maze and T-maze delayed alternation performance in ratsPharmacology Biochemistry and Behavior, 91
D. Raichlen, A. Foster, A. Seillier, A. Giuffrida, Gregory Gerdeman (2013)
Exercise-induced endocannabinoid signaling is modulated by intensityEuropean Journal of Applied Physiology, 113
D. Raichlen, A. Foster, Gregory Gerdeman, A. Seillier, A. Giuffrida (2012)
Wired to run: exercise-induced endocannabinoid signaling in humans and cursorial mammals with implications for the ‘runner’s high’Journal of Experimental Biology, 215
L. Wise, A. Thorpe, A. Lichtman (2009)
Hippocampal CB1 receptors mediate the memory impairing effects of Δ9-tetrahydrocannabinolNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 34
F. Chaouloff, Sarah Dubreucq, L. Bellocchio, G. Marsicano (2011)
Endocannabinoids and motor behavior: CB1 receptors also control running activity.Physiology, 26 2
É. Griffin, Ranya Bechara, Amy Birch, Á. Kelly (2009)
Exercise enhances hippocampal‐dependent learning in the rat: Evidence for a BDNF‐related mechanismHippocampus, 19
N. Egashira, K. Mishima, K. Iwasaki, M. Fujiwara (2002)
Intracerebral microinjections of delta 9-tetrahydrocannabinol: search for the impairment of spatial memory in the eight-arm radial maze in rats.Brain research, 952 2
H. Soya, Toru Nakamura, C. Deocaris, Akiyo Kimpara, Miho Iimura, T. Fujikawa, Hyukki Chang, B. McEwen, T. Nishijima (2007)
BDNF induction with mild exercise in the rat hippocampus.Biochemical and biophysical research communications, 358 4
Stephen Davies, R. Pertwee, Gernot Riedel (2002)
Functions of cannabinoid receptors in the hippocampusNeuropharmacology, 42
Jun Wang, N. Ueda (2009)
Biology of endocannabinoid synthesis system.Prostaglandins & other lipid mediators, 89 3-4
S. Vaynman, F. Gomez-Pinilla (2005)
License to Run: Exercise Impacts Functional Plasticity in the Intact and Injured Central Nervous System by Using NeurotrophinsNeurorehabilitation and Neural Repair, 19
Nicola Broadbent, L. Squire, R. Clark (2004)
Spatial memory, recognition memory, and the hippocampus.Proceedings of the National Academy of Sciences of the United States of America, 101 40
S. Galiègue, S. Mary, J. Marchand, D. Dussossoy, D. Carrière, P. Carayon, M. Bouaboula, D. Shire, G. Fur, P. Casellas (1995)
Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations.European journal of biochemistry, 232 1
L. Panlilio, Z. Justinova, S. Goldberg (2013)
Inhibition of FAAH and activation of PPAR: new approaches to the treatment of cognitive dysfunction and drug addiction.Pharmacology & therapeutics, 138 1
A. Hoffman, M. Oz, Ruiqin Yang, A. Lichtman, C. Lupica (2007)
Opposing actions of chronic Delta9-tetrahydrocannabinol and cannabinoid antagonists on hippocampal long-term potentiation.Learning & memory, 14 1-2
R. O’Callaghan, R. Ohle, Á. Kelly (2007)
The effects of forced exercise on hippocampal plasticity in the rat: A comparison of LTP, spatial- and non-spatial learningBehavioural Brain Research, 176
J. Gresack, K. Frick (2006)
Effects of continuous and intermittent estrogen treatments on memory in aging female miceBrain Research, 1115
M. Bradford (1976)
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.Analytical biochemistry, 72
G. Cabral, F. Marciano-cabral (2005)
Cannabinoid receptors in microglia of the central nervous system: immune functional relevanceJournal of Leukocyte Biology, 78
S. Wolf, A. Bick-Sander, K. Fabel, P. Leal-Galicia, S. Tauber, G. Ramírez-Rodríguez, Anke Müller, A. Melnik, T. Waltinger, O. Ullrich, G. Kempermann (2010)
Cannabinoid receptor CB1 mediates baseline and activity-induced survival of new neurons in adult hippocampal neurogenesisCell Communication and Signaling : CCS, 8
L. Drumond, F. Mourão, H. Leite, Renata Abreu, H. Reis, M. Moraes, G. Pereira, A. Massensini (2012)
Differential effects of swimming training on neuronal calcium sensor-1 expression in rat hippocampus/cortex and in object recognition memory tasksBrain Research Bulletin, 88
H. Praag, B. Christie, T. Sejnowski, F. Gage (1999)
Running enhances neurogenesis, learning, and long-term potentiation in mice.Proceedings of the National Academy of Sciences of the United States of America, 96 23
L. Clarkson-smith, A. Hartley (1989)
Relationships between physical exercise and cognitive abilities in older adults.Psychology and aging, 4 2
Qing-Shu Lin, Qian Yang, Dan-dan Liu, Zhe Sun, Hao Dang, Juan Liang, Yunxiao Wang, Jieyan Chen, Sheng-tian Li (2011)
Hippocampal endocannabinoids play an important role in induction of long-term potentiation and regulation of contextual fear memory formationBrain Research Bulletin, 86
A. Ferreira, C. Real, A. Rodrigues, A. Alves, L. Britto (2011)
Short-term, moderate exercise is capable of inducing structural, bdnf-independent hippocampal plasticityBrain Research, 1425
It is well known that physical exercise has positive effects on cognitive functions and hippocampal plasticity. However, the underlying mechanisms have remained to be further investigated. Here we investigated the hypothesis that the memory‐enhancement promoted by physical exercise relies on facilitation of the endocannabinoid system. We observed that the spatial memory tested in the object location paradigm did not persist in sedentary mice, but could be improved by 1 week of treadmill running. In addition, exercise up‐regulated CB1 receptor and BDNF expression in the hippocampus. To verify if these changes required CB1 activation, we treated the mice with the selective antagonist, AM251, before each period of physical activity. In line with our hypothesis, this drug prevented the exercise‐induced memory enhancement and BDNF expression. Furthermore, AM251 reduced CB1 expression. To test if facilitating the endocannabinoid system signaling would mimic the alterations observed after exercise, we treated sedentary animals during 1 week with the anandamide‐hydrolysis inhibitor, URB597. Mice treated with this drug recognized the object in a new location and have increased levels of CB1 and BDNF expression in the hippocampus, showing that potentiating the endocanabinoid system equally benefits memory. In conclusion, the favorable effects of exercise upon spatial memory and BDNF expression depend on facilitation of CB1 receptor signaling, which can be mimic by inhibition of anandamide hydrolysis in sedentary animals. Our results suggest that, at least in part, the promnesic effect of the exercise is dependent of CB1 receptor activation and is mediated by BDNF. © 2013 Wiley Periodicals, Inc.
Hippocampus – Wiley
Published: Jan 1, 2014
Keywords: ; ; ; ;
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.