Access the full text.
Sign up today, get DeepDyve free for 14 days.
References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.
FRANK B. LIVINGSTONE Department of Anthropology, University of Michigan, Ann Arbor, M I 48109 Although differential contributions to the next generation have frequently been used to measure differences in fitness, a t genetic equilibrium there will be no such differences among genotypes with balanced polymorphism. For a single locus the frequencies, after selection, of , where the three genotypes, AA, A a , aa,will be: qlp2/K2W,,pq/W and W ,q2/v, v = w,, + 2W,, pq + p2 tyz2 pa. To estimate the contribution of any genotype to the next generation, the average fitness of the offspring can be calculated from the frequencies of possible matings for that genotype and the average fitness of the offspring of each mating. For the AA genotype the average fitness of the offspring will be (K1p2/W) + (2W,,pdP) (0.5 K + 0 . 5 % ~ ) (%2 W,, + a2/WK2 or ~-1(w,l~rw,l~+w,,crl+w,2arw,2~+w,241). At genetic equilibrium, W ,p + 4,q = q 2 p+ W ,q = , , so that average fitness will be simply For the A a genotype, the average fitness of the offspring will be w. w, (qlp2/v) (0.5q1+0-5W,,) + ( 2 & 2 p 4 / v ) (0.25q1+0.5K2+0.25W,2) + (b2Q2/v) (0'5K2+0'5%,), which also reduces to p; and similarly for the aa genotype. This conclusion is only valid when selection occurs as early mortality. However, the sickle cell gene appears to be close to equilibrium in many populations in Africa ;and since most selection due to either sickle-cell anaemia or cerebral malaria occurs in early childhood, this inay explain the inconclusive nature of the data on differences in the average number of surviving offspring for sicklers and non-sicklers.
Annals of Human Genetics – Wiley
Published: Jan 1, 1977
You can share this free article with as many people as you like with the url below! We hope you enjoy this feature!
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.