A Practical Synthesis of N‐aryl/N‐alkyl 4‐Pyridones under Continuous Flow Technology
A Practical Synthesis of N‐aryl/N‐alkyl 4‐Pyridones under Continuous Flow Technology
Li, Weiqiang; Wu, Qin; Xu, Genrui; Sun, Yinjing; Huang, Chao; Liu, Teng
2021-12-01 00:00:00
In this report, a practical synthetic approach to access N‐aryl/N‐alkyl 4‐pyridones via a two‐step continuous flow process has been developed. In comparison to batch conditions, this [3+2+1] cycloaddition involving a three‐components cascade reaction of aniline, dialkyl ethoxymethyl enemalonate and dialkyl acetylenedicarboxylate under mild conditions, which can provide N‐aryl/N‐alkyl 4‐pyridone derivatives with a wider substrate scope and good to excellent yields.
http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.pngAsian Journal of Organic ChemistryWileyhttp://www.deepdyve.com/lp/wiley/a-practical-synthesis-of-n-aryl-n-alkyl-4-pyridones-under-continuous-rxZMCWCbh4
A Practical Synthesis of N‐aryl/N‐alkyl 4‐Pyridones under Continuous Flow Technology
In this report, a practical synthetic approach to access N‐aryl/N‐alkyl 4‐pyridones via a two‐step continuous flow process has been developed. In comparison to batch conditions, this [3+2+1] cycloaddition involving a three‐components cascade reaction of aniline, dialkyl ethoxymethyl enemalonate and dialkyl acetylenedicarboxylate under mild conditions, which can provide N‐aryl/N‐alkyl 4‐pyridone derivatives with a wider substrate scope and good to excellent yields.
Journal
Asian Journal of Organic Chemistry
– Wiley
Published: Dec 1, 2021
Keywords: Cascade cyclization; Flow synthesis; Metal-free; N -aryl 4-pyridone; Pyridone
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