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A Practical Synthesis of N‐aryl/N‐alkyl 4‐Pyridones under Continuous Flow Technology

A Practical Synthesis of N‐aryl/N‐alkyl 4‐Pyridones under Continuous Flow Technology In this report, a practical synthetic approach to access N‐aryl/N‐alkyl 4‐pyridones via a two‐step continuous flow process has been developed. In comparison to batch conditions, this [3+2+1] cycloaddition involving a three‐components cascade reaction of aniline, dialkyl ethoxymethyl enemalonate and dialkyl acetylenedicarboxylate under mild conditions, which can provide N‐aryl/N‐alkyl 4‐pyridone derivatives with a wider substrate scope and good to excellent yields. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Asian Journal of Organic Chemistry Wiley

A Practical Synthesis of N‐aryl/N‐alkyl 4‐Pyridones under Continuous Flow Technology

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Publisher
Wiley
Copyright
© 2021 Wiley‐VCH GmbH
ISSN
2193-5807
eISSN
2193-5815
DOI
10.1002/ajoc.202100584
Publisher site
See Article on Publisher Site

Abstract

In this report, a practical synthetic approach to access N‐aryl/N‐alkyl 4‐pyridones via a two‐step continuous flow process has been developed. In comparison to batch conditions, this [3+2+1] cycloaddition involving a three‐components cascade reaction of aniline, dialkyl ethoxymethyl enemalonate and dialkyl acetylenedicarboxylate under mild conditions, which can provide N‐aryl/N‐alkyl 4‐pyridone derivatives with a wider substrate scope and good to excellent yields.

Journal

Asian Journal of Organic ChemistryWiley

Published: Dec 1, 2021

Keywords: Cascade cyclization; Flow synthesis; Metal-free; N -aryl 4-pyridone; Pyridone

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