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A note on testing the Hardy‐Weinberg Law

A note on testing the Hardy‐Weinberg Law Pvinted i &eat Britain n A note on testing the Hardy-Weinberg Law BY CEDRIC A. B. SMITH The Galton Laboratory, University College London INTRODUCTION Suppose that we select from a large population IT a sample of n unrelated individuals. I n this population three phenotypes, G,, G,, and G, G, are distinguishable; and evidence suggests that these phenotypes correspond respectively to three genotypes G, G,, G, G,, G, G,, where G, and G, are a pair of alleles. If this is true, if G,, G, have respective frequencies p , q in the population, and if the so-called Hardy-Weinberg Law holds, then the proportions of GIG,, G,Q, and G,G, individuals in the population should be in the ratios (1.1) (This formula was essentially found first by Castle, 1903, but we shall use here the accepted name of the ‘Hardy-Weinberg Law’.) We may therefore wish to test whether this holds in the population under study. One motive for doing so is that if in fact the polymorphism is kept in existence by heterozygote advantage, then the proportions of G, B, observed should theoretically be greater than expected from the Hardy-Weinberg formula. The most usual way of testing the formula http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Human Genetics Wiley

A note on testing the Hardy‐Weinberg Law

SMITH, CEDRIC A. B.
Annals of Human Genetics , Volume 33 (4) – May 1, 1970
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References (4)

Publisher
Wiley
Copyright
Copyright © 1970 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0003-4800
eISSN
1469-1809
DOI
10.1111/j.1469-1809.1970.tb01664.x
Publisher site
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Abstract

Pvinted i &eat Britain n A note on testing the Hardy-Weinberg Law BY CEDRIC A. B. SMITH The Galton Laboratory, University College London INTRODUCTION Suppose that we select from a large population IT a sample of n unrelated individuals. I n this population three phenotypes, G,, G,, and G, G, are distinguishable; and evidence suggests that these phenotypes correspond respectively to three genotypes G, G,, G, G,, G, G,, where G, and G, are a pair of alleles. If this is true, if G,, G, have respective frequencies p , q in the population, and if the so-called Hardy-Weinberg Law holds, then the proportions of GIG,, G,Q, and G,G, individuals in the population should be in the ratios (1.1) (This formula was essentially found first by Castle, 1903, but we shall use here the accepted name of the ‘Hardy-Weinberg Law’.) We may therefore wish to test whether this holds in the population under study. One motive for doing so is that if in fact the polymorphism is kept in existence by heterozygote advantage, then the proportions of G, B, observed should theoretically be greater than expected from the Hardy-Weinberg formula. The most usual way of testing the formula

Journal

Annals of Human Genetics – Wiley

Published: May 1, 1970

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