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Summary The monoclonal antibody, H207, raised against the human T‐cell‐derived acute lymphoblastic leukaemia line HSB‐2, recognizes an antigen of apparent molecular weight 125000 which is coded for by the gene, MIC6, on chromosome 17. Assignment was based on the pattern of reactivity with a panel of somatic cell hybrids. In particular, two hybrids containing only human chromosome 17 or a human translocation chromosome t(3;17) (3pter‐3p11::17p11–17qter) respectively bound H207, whilst their revertands did not. The H207 antigen has a general tissue distribution but is not found on B‐cell lines and is lacking from some T‐cell lines.
Annals of Human Genetics – Wiley
Published: Oct 1, 1982
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