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A monoclonal antibody recognizing a cell surface antigen coded for by a gene on human chromosome 17

A monoclonal antibody recognizing a cell surface antigen coded for by a gene on human chromosome 17 Summary The monoclonal antibody, H207, raised against the human T‐cell‐derived acute lymphoblastic leukaemia line HSB‐2, recognizes an antigen of apparent molecular weight 125000 which is coded for by the gene, MIC6, on chromosome 17. Assignment was based on the pattern of reactivity with a panel of somatic cell hybrids. In particular, two hybrids containing only human chromosome 17 or a human translocation chromosome t(3;17) (3pter‐3p11::17p11–17qter) respectively bound H207, whilst their revertands did not. The H207 antigen has a general tissue distribution but is not found on B‐cell lines and is lacking from some T‐cell lines. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Human Genetics Wiley

A monoclonal antibody recognizing a cell surface antigen coded for by a gene on human chromosome 17

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References (66)

Publisher
Wiley
Copyright
Copyright © 1982 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0003-4800
eISSN
1469-1809
DOI
10.1111/j.1469-1809.1982.tb01584.x
Publisher site
See Article on Publisher Site

Abstract

Summary The monoclonal antibody, H207, raised against the human T‐cell‐derived acute lymphoblastic leukaemia line HSB‐2, recognizes an antigen of apparent molecular weight 125000 which is coded for by the gene, MIC6, on chromosome 17. Assignment was based on the pattern of reactivity with a panel of somatic cell hybrids. In particular, two hybrids containing only human chromosome 17 or a human translocation chromosome t(3;17) (3pter‐3p11::17p11–17qter) respectively bound H207, whilst their revertands did not. The H207 antigen has a general tissue distribution but is not found on B‐cell lines and is lacking from some T‐cell lines.

Journal

Annals of Human GeneticsWiley

Published: Oct 1, 1982

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