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L. Kruglyak (1999)
Prospects for whole-genome linkage disequilibrium mapping of common disease genesNature Genetics, 22
J. Terwilliger, J. Ott (1994)
Handbook of Human Genetic Linkage
D. Pauls (1999)
A complete genome screen in sib pairs affected by Gilles de la Tourette syndrome. The Tourette Syndrome Association International Consortium for Genetics.American journal of human genetics, 65 5
M. Seiler, F. Seiler (1989)
Numerical Recipes in C: The Art of Scientific ComputingRisk Analysis, 9
W. Ewens (1999)
Statistical aspects of the transmission/disequilibrium test (TDT)
Jian Huang, Yanming Jiang (1999)
Linkage detection adaptive to linkage disequilibrium: the disequilibrium maximum-likelihood-binomial test for affected-sibship data.American journal of human genetics, 65 6
E. Lander, L. Kruglyak (1995)
Genetic dissection of complex traits: guidelines for interpreting and reporting linkage resultsNature Genetics, 11
J. Faraway (1993)
Distribution of the admixture test for the detection of linkage under heterogeneityGenetic Epidemiology, 10
Ravi Sachidanandam, David Weissman, Steven Schmidt, Jerzy Kakol, Lincoln Stein, Gabor Marth, Steve Sherry, J. Mullikin, B. Mortimore, David Willey, S. Hunt, Charlotte Cole, Penny Coggill, C. Rice, Zemin Ning, J. Rogers, D. Bentley, Pui-Yan Kwok, E. Mardis, Raymond Yeh, Brian Schultz, L. Cook, Ruth Davenport, M. Dante, L. Fulton, L. Hillier, Robert Waterston, J. Mcpherson, Brian Gilman, Stephen Schaffner, W. Etten, David Reich, J. Higgins, Mark Daly, B. Blumenstiel, J. Baldwin, N. Stange-thomann, M. Zody, L. Linton, Eric Lander, D. Altshuler (2001)
A map of human genome sequence variation containing 1.42 million single nucleotide polymorphismsNature, 409
L. Abel, A. Alcais, A. Mallet (1998)
Comparison of four sib‐pair linkage methods for analyzing sibships with more than two affecteds: Interest of the binomial maximum likelihood approachGenetic Epidemiology, 15
J. Altmüller, L. Palmer, L. Palmer, G. Fischer, H. Scherb, Matthias Wjst (2001)
Genomewide scans of complex human diseases: true linkage is hard to find.American journal of human genetics, 69 5
W. Press (1994)
Numerical recipes in C++: the art of scientific computing, 2nd Edition (C++ ed., print. is corrected to software version 2.10)
J. Ott (1985)
Analysis of Human Genetic Linkage
P. Abreu, S. Hodge, D. Greenberg (2002)
Quantification of type I error probabilities for heterogeneity LOD scoresGenetic Epidemiology, 22
J. Stephens, J. Schneider, D. Tanguay, Julie Choi, Tara Acharya, S. Stanley, Ruhong Jiang, Chad Messer, A. Chew, Jinglin Han, Jicheng Duan, Janet Carr, Min Lee, B. Koshy, A. Kumar, Ge Zhang, W. Newell, A. Windemuth, Chuanbo Xu, T. Kalbfleisch, S. Shaner, Kevin Arnold, Vincent Schulz, Connie Drysdale, K. Nandabalan, R. Judson, G. Ruaño, G. Vovis (2001)
Haplotype Variation and Linkage Disequilibrium in 313 Human GenesScience, 293
Ingrid Simonic, Dale Nyholt, G. Gericke, Derek Gordon, Naomichi Matsumoto, David Ledbetter, Jurg Ott, James Weber (2001)
Further evidence for linkage of Gilles de la Tourette syndrome (GTS) susceptibility loci on chromosomes 2p11, 8q22 and 11q23-24 in South African Afrikaners.American journal of medical genetics, 105 2
W. Ewens (2000)
A hundred years of population genetics theory.Journal of epidemiology and biostatistics, 5 1
S. Horvath, C. Windemuth, M. Knapp (2000)
The disequilibrium maximum-likelihood-binomial test does not replace the transmission/disequilibrium test.American journal of human genetics, 67 2
C. Crouse, E. Lehmann (1960)
Testing Statistical Hypothesis.Biometrika, 47
Laurent Abel, Bertram Müller-Myhsok (1998)
Robustness and power of the maximum-likelihood-binomial and maximum-likelihood-score methods, in multipoint linkage analysis of affected-sibship data.American journal of human genetics, 63 2
D. Reich, M. Cargill, S. Bolk, J. Ireland, Pardis Sabeti, D. Richter, T. Lavery, Rose Kouyoumjian, S. Farhadian, R. Ward, E. Lander (2001)
Linkage disequilibrium in the human genomeNature, 411
R. Spielman, R. McGinnis, Warren Ewenst (1993)
Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM).American journal of human genetics, 52 3
(1999)
A complete genome screen in sib pairs affected by Gilles de la Tourette syndrome, 65
G. Johnson, L. Esposito, B. Barratt, Annabel Smith, J. Heward, G. Genova, H. Ueda, H. Cordell, I. Eaves, F. Dudbridge, R. Twells, F. Payne, Wil Hughes, S. Nutland, H. Stevens, Phill Carr, E. Tuomilehto-Wolf, J. Tuomilehto, S. Gough, D. Clayton, J. Todd (2001)
Haplotype tagging for the identification of common disease genesNature Genetics, 29
This paper presents a marginal likelihood model for family‐based data based upon the transmission of marker alleles from each heterozygous parent to his/her affected children. The proposed model, extending the maximum‐likelihood‐binomial (MLB) method and the disequilibrium maximum‐likelihood‐binomial (DMLB) method (Abel et al. 1998; Abel & Müller‐Myhsok, 1998; Huang & Jiang, 1999), is adaptive to linkage disequilibrium (LD) and linkage heterogeneity. Compared with other procedures, the likelihood ratio test (LRT) derived from the proposed model enjoys superior qualities. First, simulations indicate that the power of the LRT is greater than that of the TDT or DMLB in all of our studied scenarios. Second, when we applied the LRT and other tests to a Tourette Syndrome data, the result was data favorable to the use of the LRT. Therefore, we recommend the use of the LRT as an additional linkage test wherever applicable, especially when the amount of LD is uncertain.
Annals of Human Genetics – Wiley
Published: Jan 1, 2003
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