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A likelihood ratio test for detecting patterns of disease‐marker association

A likelihood ratio test for detecting patterns of disease‐marker association A likelihood ratio test of disease‐marker association is proposed, based on the observation of marker alleles transmitted from parents to affected children. The proposed association test has the advantage of identifying the population pattern of disease‐marker association, differentiating between marker alleles that are positively and negatively associated with the disease. The power of the test for detecting association is evaluated and compared with three existing multi‐allelic tests for some specific disease‐marker association patterns. The power of the parametric tests depends crucially on the pattern of disease‐marker association. An over‐parameterised association model is less detrimental in terms of power than an under parameterised model. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Human Genetics Wiley

A likelihood ratio test for detecting patterns of disease‐marker association

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References (19)

Publisher
Wiley
Copyright
Copyright © 1997 Wiley Subscription Services
ISSN
0003-4800
eISSN
1469-1809
DOI
10.1046/j.1469-1809.1997.6140335.x
pmid
9365786
Publisher site
See Article on Publisher Site

Abstract

A likelihood ratio test of disease‐marker association is proposed, based on the observation of marker alleles transmitted from parents to affected children. The proposed association test has the advantage of identifying the population pattern of disease‐marker association, differentiating between marker alleles that are positively and negatively associated with the disease. The power of the test for detecting association is evaluated and compared with three existing multi‐allelic tests for some specific disease‐marker association patterns. The power of the parametric tests depends crucially on the pattern of disease‐marker association. An over‐parameterised association model is less detrimental in terms of power than an under parameterised model.

Journal

Annals of Human Genetics – Wiley

Published: Jan 1, 1997

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