Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/wiley/a-large-scale-screen-for-coding-variants-in-sert-slc6a4-in-autism-AJqaYH8pZt
References (18)
-
J. Wendland, T. Deguzman, F. McMahon, G. Rudnick, S. Detera-Wadleigh, D. Murphy (2008)
SERT Ileu425Val in autism, Asperger syndrome and obsessive–compulsive disorderPsychiatric Genetics, 18
-
J. Sutcliffe, Ryan Delahanty, H. Prasad, J. McCauley, Q. Han, Lan Jiang, Chun Li, S. Folstein, R. Blakely (2005)
Allelic heterogeneity at the serotonin transporter locus (SLC6A4) confers susceptibility to autism and rigid-compulsive behaviors.American journal of human genetics, 77 2
-
D. Reich, D. Goldstein (2001)
Detecting association in a case‐control study while correcting for population stratificationGenetic Epidemiology, 20
-
Bernie Devlin, Edwin Cook, Hilary Coon, Geraldine Dawson, William McMahon, N. Minshew, David Pauls, C. Stodgell (2005)
Autism and the serotonin transporter: the long and short of itMolecular Psychiatry, 10
-
Soo-Jeong Kim, N. Cox, Rachel Courchesne, C. Lord, Christina Corsello, N. Akshoomoff, Stephen Guter, Bennett Leventhal, E. Courchesne, E. Cook (2002)
Transmission disequilibrium mapping at the serotonin transporter gene (SLC6A4) region in autistic disorderMolecular Psychiatry, 7
-
M. Grados, J. Samuels, Y. Shugart, V. Willour, Y. Wang, B. Cullen, O. Bienvenu, R. Hoehn-Saric, D. Valle, K. Liang, M. Riddle, J. Wendland, D. Murphy, G. Nestadt, S. Detera-Wadleigh (2007)
Rare plus common SERT variants in obsessive-compulsive disorderMolecular Psychiatry, 12
-
N. Ozaki, D. Goldman, W. Kaye, K. Plotnicov, Benjamin Greenberg, Benjamin Greenberg, J. Lappalainen, G. Rudnick, D. Murphy (2003)
Serotonin transporter missense mutation associated with a complex neuropsychiatric phenotypeMolecular Psychiatry, 8
-
Camille Brune, Soo-Jeong Kim, Jeff Salt, B. Leventhal, C. Lord, E. Cook (2006)
5-HTTLPR Genotype-Specific Phenotype in Children and Adolescents With Autism.The American journal of psychiatry, 163 12
-
Amanda Yonan, A. Palmer, T. Gilliam (2006)
Hardy-Weinberg disequilibrium identified genotyping error of the serotonin transporter (SLC6A4) promoter polymorphism.Psychiatric genetics, 16 1
-
N. Ramoz, J. Reichert, Thomas Corwin, Christopher Smith, J. Silverman, E. Hollander, J. Buxbaum (2006)
Lack of Evidence for Association of the Serotonin Transporter Gene SLC6A4 with AutismBiological Psychiatry, 60
-
M. Faham, Jianbiao Zheng, M. Moorhead, H. Fakhrai-Rad, Eugeni Namsaraev, K. Wong, Zhiyong Wang, Shu Chow, L. Lee, K. Suyenaga, J. Reichert, A. Boudreau, J. Eberle, C. Bruckner, Maneesh Jain, G. Karlin-Neumann, H. Jones, T. Willis, J. Buxbaum, Ronald Davis (2005)
Multiplexed variation scanning for 1,000 amplicons in hundreds of patients using mismatch repair detection (MRD) on tag arrays.Proceedings of the National Academy of Sciences of the United States of America, 102 41
-
J. McCauley, L. Olson, Michael Dowd, T. Amin, A. Steele, R. Blakely, S. Folstein, J. Haines, J. Sutcliffe (2004)
Linkage and association analysis at the serotonin transporter (SLC6A4) locus in a rigid‐compulsive subset of autismAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 127B
-
J. Wendland, M. Kruse, D. Murphy (2006)
Functional SLITRK1 var321, varCDfs and SLC6A4 G56A variants and susceptibility to obsessive-compulsive disorderMolecular Psychiatry, 11
-
D. Keen-Kim, C. Mathews, V. Reus, T. Lowe, L. Herrera, C. Budman, V. Gross‐Tsur, A. Pulver, R. Bruun, G. Erenberg, A. Naarden, C. Sabatti, N. Freimer (2006)
Overrepresentation of rare variants in a specific ethnic group may confuse interpretation of association analyses.Human molecular genetics, 15 22
-
R. Delorme, C. Betancur, M. Wagner, M. Krebs, P. Gorwood, P. Pearl, G. Nygren, C. Durand, F. Buhtz, P. Pickering, J. Melke, S. Ruhrmann, H. Anckarsäter, N. Chabane, A. Kipman, C. Reck, B. Millet, I. Roy, M. Mouren-Siméoni, W. Maier, M. Råstam, C. Gillberg, M. Leboyer, T. Bourgeron (2005)
Support for the association between the rare functional variant I425V of the serotonin transporter gene and susceptibility to obsessive compulsive disorderMolecular Psychiatry, 10
-
H. Prasad, Chong-Bin Zhu, J. McCauley, D. Samuvel, S. Ramamoorthy, R. Shelton, W. Hewlett, J. Sutcliffe, R. Blakely (2005)
Human serotonin transporter variants display altered sensitivity to protein kinase G and p38 mitogen-activated protein kinase.Proceedings of the National Academy of Sciences of the United States of America, 102 32
-
Judith Conroy, E. Meally, G. Kearney, Michael Fitzgerald, M. Gill, Louise Gallagher (2004)
Serotonin transporter gene and autism: a haplotype analysis in an Irish autistic populationMolecular Psychiatry, 9
-
E. Cook, Bennett Leventhal (1996)
The serotonin system in autism.Current opinion in pediatrics, 8 4
- Publisher
- Wiley
- Copyright
- Copyright © 2008, International Society for Autism Research, Wiley‐Liss, Inc.
- ISSN
- 1939-3792
- eISSN
- 1939-3806
- DOI
- 10.1002/aur.30
- pmid
- 19360675
- Publisher site
- See Article on Publisher Site
Abstract
In the current study we explored the hypothesis that rare variants in SLC6A4 contribute to autism susceptibility and to rigid‐compulsive behaviors in autism. We made use of a large number of unrelated cases with autism spectrum disorders (∼350) and controls (∼420) and screened for rare exonic variants in SLC6A4 by a high‐throughput method followed by sequencing. We observed no difference in the frequency of such variants in the two groups, irrespective of how we defined the rare variants. Furthermore, we did not observe an association of rare coding variants in SLC6A4 with rigid‐compulsive traits scores in the cases. These results do not support a significant role for rare coding variants in SLC6A4 in autism spectrum disorders, nor do they support a significant role for SLC6A4 in rigid‐compulsive traits in these disorders.
Journal
Autism Research – Wiley
Published: Aug 1, 2008