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A highly reproducible cervical cuff technique for rat‐to‐mouse heterotopic heart xenotransplantation

A highly reproducible cervical cuff technique for rat‐to‐mouse heterotopic heart xenotransplantation Xenotransplantation is an effective way to solve the problem of donor shortage in clinical transplantation. However, clinical use of xenotransplantation is currently limited due to immunological challenges such as acute vascular rejection and cell‐mediated rejection. To finally surpass this immunological barrier, more preclinical research is needed into the molecular mechanisms of rejection and the possible effects of new immunosuppressants. Our aim was to create a refined, highly reproducible protocol to establish the most suitable rat‐to‐mouse heterotopic heart transplantation model using the cuff technique. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Xenotransplantation Wiley

A highly reproducible cervical cuff technique for rat‐to‐mouse heterotopic heart xenotransplantation

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References (16)

Publisher
Wiley
Copyright
© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
ISSN
0908-665X
eISSN
1399-3089
DOI
10.1111/xen.12331
pmid
28833558
Publisher site
See Article on Publisher Site

Abstract

Xenotransplantation is an effective way to solve the problem of donor shortage in clinical transplantation. However, clinical use of xenotransplantation is currently limited due to immunological challenges such as acute vascular rejection and cell‐mediated rejection. To finally surpass this immunological barrier, more preclinical research is needed into the molecular mechanisms of rejection and the possible effects of new immunosuppressants. Our aim was to create a refined, highly reproducible protocol to establish the most suitable rat‐to‐mouse heterotopic heart transplantation model using the cuff technique.

Journal

XenotransplantationWiley

Published: Jan 1, 2017

Keywords: ; ; ; ;

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