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A general model for disease‐marker association

A general model for disease‐marker association Summary A general model for analysing disease‐marker associations from a random sample of patients and controls is given, assuming an arbitrary number of marker and disease susceptibility alleles. A method for testing the goodness‐of‐fit of various disease susceptibility models to the observed distribution of genotypes at the marker locus in patient and control samples is given. The method is demonstrated using a recently published data set on type I diabetes. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Human Genetics Wiley

A general model for disease‐marker association

Annals of Human Genetics , Volume 47 (3) – Jul 1, 1983

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References (14)

Publisher
Wiley
Copyright
Copyright © 1983 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0003-4800
eISSN
1469-1809
DOI
10.1111/j.1469-1809.1983.tb00992.x
Publisher site
See Article on Publisher Site

Abstract

Summary A general model for analysing disease‐marker associations from a random sample of patients and controls is given, assuming an arbitrary number of marker and disease susceptibility alleles. A method for testing the goodness‐of‐fit of various disease susceptibility models to the observed distribution of genotypes at the marker locus in patient and control samples is given. The method is demonstrated using a recently published data set on type I diabetes.

Journal

Annals of Human GeneticsWiley

Published: Jul 1, 1983

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