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(1951)
Genetics of the hnman race
A diagrammatic representation of the proportions of genotypes and phenotypes in a panmictic population BY C. C. LI Grndunte School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, U . S . A . When there are two alleles, say A and a , with frequencies p and q, respectively, the three genotypic proportions p2, 2pq, q2 in a random mating population are usually represented as parts of a unit square, each side of which is divided into two segments of length p and q. Thus. the homozygote proportions p 2 and q2 would actually appear as two squares and the heterozygote proportion is represented by two separate rectangles, each of size p x q. This seems the easiest and the most ânaturalâ way to present the genotypic proportions. However, when there are more than two alleles, especially when there is a certain dominance pattern between the alleles, the unit square is no longer the simplest diagram to present the various genotypic proportions. In fact, it has two undesirable features: first, the heterozygote proportion is represented by two rectangles which may be widely separated in the diagram; secondly, the heterozygote area is not necessarily adjacent to the homozygote
Annals of Human Genetics – Wiley
Published: Nov 1, 1959
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