Access the full text.
Sign up today, get DeepDyve free for 14 days.
(1977)
Several of the adenosine deaminase isozymes are adenosine deaminase activity and deoxyadenosine catabolism
M. Stoker (1973)
Role of Diffusion Boundary Layer in Contact Inhibition of GrowthNature, 246
R. Eisenthal, A. Cornish-Bowden (1974)
The direct linear plot. A new graphical procedure for estimating enzyme kinetic parameters.The Biochemical journal, 139 3
M. Coleman, J. Donofrio, J. Hutton, L. Hahn, A. Daoud, B. Lampkin, J. Dyminski (1978)
Identification and quantitation of adenine deoxynucleotides in erythrocytes of a patient with adenosine deaminase deficiency and severe combined immunodeficiency.The Journal of biological chemistry, 253 5
D. Hopkinson, P. Cook, H. Harris (1969)
Further data on the adenosine deaminase (ADA) polymorphism and a report of a new phenotypeAnnals of Human Genetics, 32
H. Simmonds, G. Panayi, V. Corrigall (1978)
A ROLE FOR PURINE METABOLISM IN THE IMMUNE RESPONSE: ADENOSINE-DEAMINASE ACTIVITY AND DEOXYADENOSINE CATABOLISMThe Lancet, 311
E. Giblett, J. Anderson, Flossie Cohen, B. Pollara, H. Meuwissen (1972)
Adenosine-deaminase deficiency in two patients with severely impaired cellular immunity.Lancet, 2 7786
W. Osborne, N. Spencer (1973)
Partial purification and properties of the common inherited forms of adenosine deaminase from human erythrocytes.The Biochemical journal, 133 1
(1978)
A role for purine metabolism in the immune response: SPENCER
D. Swallow, L. Evans, D. Hopkinson (1977)
Several of the adenosine deaminase isozymes are glycoproteinsNature, 269
A. Cohen, R. Hirschhorn, S. Horowitz, Arieh Rubinstein, S. Polmar, R. Hong, D. Martin (1978)
Deoxyadenosine triphosphate as a potentially toxic metabolite in adenosine deaminase deficiency.Proceedings of the National Academy of Sciences of the United States of America, 75 1
N. Spencer, D. Hopkinson, H. Harris (1968)
Adenosine deaminase polymorphism in manAnnals of Human Genetics, 32
(1958)
Practical Huematology, 2nd ed
(1973)
Partial purification and properties of the common inherited forms
G. Battistuzzi, R. Scozzari, P. Santolamazza, L. Terrenato, G. Modiano (1974)
Comparative activity of red cell adenosine deaminase allelic formsNature, 251
S. Frederiksen (1966)
Specificity of adenosine deaminase toward adenosine and 2'-deoxyadenosine analogues.Archives of biochemistry and biophysics, 113 2
(1977)
Several of the adenosine deaminase isozymes are adenosine deaminase activity and deoxyadenosine catabolism . Lancet i , 60 - 63 . Genet . 32 , S 14 . glycoproteins
R. Hirschhorn, V. Levytaka, B. Pollara, H. Meuwissen (1973)
Evidence for control of several different tissue-specific isozymes of adenosine deaminase by a single genetic locus.Nature: New biology, 246 155
SUMMARY Adenosine deaminase activity has been measured in red cells from individuals of known ADA phenotype (ADA 1, ADA 2‐1, ADA 3‐1, ADA 3‐2) using adenosine and 2′‐deoxyadenosine as substrates. No significant differences were observed among the phenotypes in their relative deaminase activity with the two substrates. However, evidence suggests the occurrence of an uncommon allele designated ADA1wdetermining low levels of ADA activity. The deaminase activities of the phenotypes were in the order ADA 1 > ADA 2‐1 > ADA 3‐1 > ADA 3‐2 with both substrates. The relative activities of the alleles were estimated to be: ADA1 100%, ADA2 89%, ADA3 28% and ADA1 67% with adenosine, and ADA1 100%, ADA2 87%, ADA3 39% and ADA1 66% with 2′‐deoxyadenosine. The Michaelis constants for adenosine and 2'‐deoxyadenosine were determined for the different phenotypes. There were no significant differences in these values among the phenotypes.
Annals of Human Genetics – Wiley
Published: Feb 1, 1981
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.