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3D electron diffraction for structure determination of small‐molecule nanocrystals: A possible breakthrough for the pharmaceutical industry

3D electron diffraction for structure determination of small‐molecule nanocrystals: A possible... Nanomedicine is among the most fascinating areas of research. Most of the newly discovered pharmaceutical polymorphs, as well as many new synthesized or isolated natural products, appear only in form of nanocrystals. The development of techniques that allow investigating the atomic structure of nanocrystalline materials is therefore one of the most important frontiers of crystallography. Some unique features of electrons, like their non‐neutral charge and their strong interaction with matter, make this radiation suitable for imaging and detecting individual atoms, molecules, or nanoscale objects down to sub‐angstrom resolution. In the recent years the development of three‐dimensional (3D) electron diffraction (3D ED) has shown that electron diffraction can be successfully used to solve the crystal structure of nanocrystals and most of its limiting factors like dynamical scattering or limited completeness can be easily overcome. This article is a review of the state of the art of this method with a specific focus on how it can be applied to beam sensitive samples like small‐molecule organic nanocrystals. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology Wiley

3D electron diffraction for structure determination of small‐molecule nanocrystals: A possible breakthrough for the pharmaceutical industry

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References (139)

Publisher
Wiley
Copyright
Copyright © 2022 Wiley Periodicals LLC.
ISSN
1939-5116
eISSN
1939-0041
DOI
10.1002/wnan.1810
Publisher site
See Article on Publisher Site

Abstract

Nanomedicine is among the most fascinating areas of research. Most of the newly discovered pharmaceutical polymorphs, as well as many new synthesized or isolated natural products, appear only in form of nanocrystals. The development of techniques that allow investigating the atomic structure of nanocrystalline materials is therefore one of the most important frontiers of crystallography. Some unique features of electrons, like their non‐neutral charge and their strong interaction with matter, make this radiation suitable for imaging and detecting individual atoms, molecules, or nanoscale objects down to sub‐angstrom resolution. In the recent years the development of three‐dimensional (3D) electron diffraction (3D ED) has shown that electron diffraction can be successfully used to solve the crystal structure of nanocrystals and most of its limiting factors like dynamical scattering or limited completeness can be easily overcome. This article is a review of the state of the art of this method with a specific focus on how it can be applied to beam sensitive samples like small‐molecule organic nanocrystals.

Journal

Wiley Interdisciplinary Reviews: Nanomedicine and NanobiotechnologyWiley

Published: Sep 1, 2022

Keywords: 3D electron diffraction; electron crystallography; pharmaceutics; small‐molecule organics; structure solution

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