Access the full text.
Sign up today, get DeepDyve free for 14 days.
F. Routledge, T. Campbell, J. McFetridge-Durdle, S. Bacon (2010)
Improvements in heart rate variability with exercise therapy.The Canadian journal of cardiology, 26 6
A. Fernandes, Y. Sens, V. Xavier, L. Miorin, V. Alves (2019)
Functional and Respiratory Capacity of Patients with Chronic Kidney Disease Undergoing Cycle Ergometer Training during Hemodialysis Sessions: A Randomized Clinical TrialInternational Journal of Nephrology, 2019
Israel Campos, L. Chan, Hanjie Zhang, Sheila Deziel, Cheryl Vaughn, Anna Meyring-Wösten, P. Kotanko (2016)
Intradialytic Hypoxemia in Chronic Hemodialysis PatientsBlood Purification, 41
R. Lang, L. Badano, V. Mor-Avi, J. Afilalo, A. Armstrong, L. Ernande, F. Flachskampf, E. Foster, S. Goldstein, T. Kuznetsova, P. Lancellotti, D. Muraru, M. Picard, E. Rietzschel, L. Rudski, K. Spencer, W. Tsang, J. Voigt (2015)
Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging.European heart journal cardiovascular Imaging, 16 3
S. Ting, H. Iqbal, H. Kanji, T. Hamborg, N. Aldridge, N. Krishnan, C. Imray, P. Banerjee, R. Bland, R. Higgins, D. Zehnder (2014)
Functional cardiovascular reserve predicts survival pre-kidney and post-kidney transplantation.Journal of the American Society of Nephrology : JASN, 25 1
D. Kitzman, L. Groban (2011)
Exercise intolerance.Cardiology clinics, 29 3
J. Grewal, R. McCully, G. Kane, C. Lam, P. Pellikka (2009)
Left ventricular function and exercise capacity.JAMA, 301 3
D. Kirkman, B. Muth, Joseph Stock, R. Townsend, D. Edwards (2018)
Cardiopulmonary exercise testing reveals subclinical abnormalities in chronic kidney diseaseEuropean Journal of Preventive Cardiology, 25
Kenneth Lim, S. Ting, T. Hamborg, G. McGregor, D. Oxborough, C. Tomkins, Dihua Xu, R. Thadhani, G. Lewis, R. Bland, P. Banerjee, S. Fletcher, N. Krishnan, R. Higgins, D. Zehnder, T. Hiemstra (2020)
Cardiovascular Functional Reserve Before and After Kidney Transplant.JAMA cardiology
Courtney Tuegel, N. Bansal (2017)
Heart failure in patients with kidney diseaseHeart, 103
P. Kotanko (2005)
Cause and Consequences of Sympathetic Hyperactivity in Chronic Kidney DiseaseBlood Purification, 24
A. Craenenbroeck, E. Craenenbroeck, K. Ackeren, V. Hoymans, G. Verpooten, C. Vrints, M. Couttenye (2015)
Impaired vascular function contributes to exercise intolerance in chronic kidney disease.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 31 12
P. Squara, D. Denjean, P. Estagnasié, A. Brusset, J. Dib, C. Dubois (2007)
Noninvasive cardiac output monitoring (NICOM): a clinical validationIntensive Care Medicine, 33
A. Vinet, S. Nottin, A.-M. Lecoq, P. Obert (2002)
Cardiovascular Responses to Progressive Cycle Exercise in Healthy Children and AdultsInternational Journal of Sports Medicine, 23
R. Arena, J. Myers, Joshua Abella, S. Pinkstaff, P. Brubaker, B. Moore, D. Kitzman, M. Peberdy, D. Bensimhon, P. Chase, D. Forman, Erin West, M. Guazzi (2009)
Determining the Preferred Percent-Predicted Equation for Peak Oxygen Consumption in Patients With Heart FailureCirculation: Heart Failure, 2
P. Painter (2009)
Determinants of exercise capacity in CKD patients treated with hemodialysis.Advances in chronic kidney disease, 16 6
F. Tentori, A. Karaboyas, B. Robinson, Hal, Morgenstern, Jinyao Zhang, Ananda Sen, T. Alp, kizler, Hugh, Rayner, R. Fissell, R. Vanholder, T. Tomo, F. Port (2013)
Association of dialysate bicarbonate concentration with mortality in the Dialysis Outcomes and Practice Patterns Study (DOPPS).American journal of kidney diseases : the official journal of the National Kidney Foundation, 62 4
Thomas Jones, David Houghton, S. Cassidy, Guy MacGowan, Guy MacGowan, M. Trenell, D. Jakovljevic (2015)
Bioreactance is a reliable method for estimating cardiac output at rest and during exercise.British journal of anaesthesia, 115 3
D. Frewin, F. Bartholomeusz, M. Cummings, A. Clarkson, L. Barry, B. Furber, C. Lorenzo, J. Jonsson, W. Taylor (1984)
Changes in plasma catecholamine levels during hemodialysis.Australian and New Zealand journal of medicine, 14 1
P. Kinnear, Colin Gray (2005)
SPSS 12 Made Simple.
P. Castellino, M. Bia, R. DeFronzo (1987)
Metabolic response to exercise in dialysis patients.Kidney international, 32 6
G. Balady, R. Arena, K. Sietsema, J. Myers, Lola Coke, G. Fletcher, D. Forman, B. Franklin, M. Guazzi, M. Gulati, S. Keteyian, C. Lavie, R. Macko, D. Mancini, R. Milani (2010)
Clinician's Guide to cardiopulmonary exercise testing in adults: a scientific statement from the American Heart Association.Circulation, 122 2
S. Ting, T. Hamborg, G. McGregor, D. Oxborough, Kenneth Lim, S. Koganti, N. Aldridge, C. Imray, R. Bland, S. Fletcher, N. Krishnan, R. Higgins, J. Townend, P. Banerjee, D. Zehnder (2015)
Reduced Cardiovascular Reserve in Chronic Kidney Failure: A Matched Cohort Study.American journal of kidney diseases : the official journal of the National Kidney Foundation, 66 2
H. Wallin, A. Asp, C. Wallquist, E. Jansson, K. Caidahl, Britta Rössner, S. Jacobson, A. Rickenlund, M. Eriksson (2018)
Gradual reduction in exercise capacity in chronic kidney disease is associated with systemic oxygen delivery factorsPLoS ONE, 13
R. Faria, N. Fernandes, Júlio Lovisi, M. Reboredo, M. Marta, B. Pinheiro, M. Bastos (2013)
Pulmonary function and exercise tolerance are related to disease severity in pre-dialytic patients with chronic kidney disease: a cross-sectional studyBMC Nephrology, 14
Abbas Fadaii, Homayoun Koohi-Kamali, B. Bagheri, Fatemeh Hamidimanii, Bahar Taherkhanchi (2012)
Prevalence of pulmonary hypertension in patients undergoing hemodialysis.Iranian journal of kidney diseases, 7 1
Julianne Wright, A. Hutchison (2009)
Cardiovascular disease in patients with chronic kidney diseaseVascular Health and Risk Management, 5
F. Husain‐Syed, P. McCullough, H. Birk, M. Renker, A. Brocca, W. Seeger, C. Ronco (2015)
Cardio-Pulmonary-Renal Interactions: A Multidisciplinary Approach.Journal of the American College of Cardiology, 65 22
A. Rivera-Brown, W. Frontera (2012)
Principles of Exercise Physiology: Responses to Acute Exercise and Long‐term Adaptations to TrainingPM&R, 4
Anna Meyring-Wösten, Hanjie Zhang, Xiaoling Ye, Doris Fuertinger, L. Chan, F. Kappel, M. Artemyev, N. Ginsberg, Yuedong Wang, S. Thijssen, P. Kotanko (2016)
Intradialytic Hypoxemia and Clinical Outcomes in Patients on Hemodialysis.Clinical journal of the American Society of Nephrology : CJASN, 11 4
K. Sietsema, A. Amato, S. Adler, E. Brass (2004)
Exercise capacity as a predictor of survival among ambulatory patients with end-stage renal disease.Kidney international, 65 2
A. Kettner, A. Goldberg, J. Hagberg, J. Delmez, H. Harter (1984)
Cardiovascular and metabolic responses to submaximal exercise in hemodialysis patients.Kidney international, 26 1
H. Mukai, Pei Ming, B. Lindholm, O. Heimbürger, P. Bárány, P. Stenvinkel, A. Qureshi (2018)
Lung Dysfunction and Mortality in Patients with Chronic Kidney DiseaseKidney and Blood Pressure Research, 43
E. Segura-Ortí (2010)
[Exercise in haemodyalisis patients: a literature systematic review].Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 30 2
Maximal O2 uptake is impaired in end-stage renal disease (ESRD), reducing quality of life and longevity. While determinants of maximal exercise intolerance are well defined, little is known of limitation during submaximal constant load exercise. By comparing individuals with ESRD and healthy controls, the aim of this exploratory study was to characterize mechanisms of exercise intolerance in participants with ESRD by assessing cardiopulmonary physiology at rest and during exercise. Resting spirometry and echocardiography were performed in 20 dialysis-dependent participants with ESRD (age: 59 ± 12 yr, 14 men and 6 women) and 20 healthy age- and sex-matched controls. Exercise tolerance was assessed with ventilatory gas exchange and central hemodynamics during a maximal cardiopulmonary exercise test and 30 min of submaximal constant load exercise. Left ventricular mass (292 ± 102 vs. 185 ± 83 g, P = 0.01) and filling pressure (E/e′: 6.48 ± 3.57 vs. 12.09 ± 6.50 m/s, P = 0.02) were higher in participants with ESRD; forced vital capacity (3.44 ± 1 vs. 4.29 ± 0.95 L/min, P = 0.03) and peak O2 uptake (13.3 ± 2.7 vs. 24.6 ± 7.3 mL·kg−1·min−1, P < 0.001) were lower. During constant load exercise, the relative increase in the arterial-venous O2 difference (13 ± 18% vs. 74 ± 18%) and heart rate (32 ± 18 vs. 75 ± 29%) were less in participants with ESRD despite exercise being performed at a higher percentage of maximum minute ventilation (48 ± 3% vs. 39 ± 3%) and heart rate (82 ± 2 vs. 64 ± 2%). Ventilatory and chronotropic incompetence contribute to exercise intolerance in individuals with ESRD. Both are potential targets for medical and lifestyle interventions.
American Journal of Physiology-Renal Physiology – The American Physiological Society
Published: Sep 1, 2020
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.