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JL van der Velden, Y Ye, JD Nolin, SM Hoffman, DG Chapman, KG Lahue, S Abdalla, P Chen, Y Liu, B Bennett, N Khalil, D Sutherland, W Smith, G Horan, M Assaf, Z Horowitz, R Chopra, RM Stevens, M Palmisano, YM Janssen-Heininger, PH Schafer (2016)
JNK inhibition reduces lung remodeling and pulmonary fibrotic systemic markers, 5
A. Sureshbabu, S. Muhsin, Mary Choi (2016)
TGF-β signaling in the kidney: profibrotic and protective effects.American journal of physiology. Renal physiology, 310 7
S Kitamura, N Horimoto, K Tsuji, A Inoue, K Takiue, H Sugiyama, H Makino (2014)
The selection of peritoneal mesothelial cells is important for cell therapy to prevent peritoneal fibrosis, 20
R Kramann, F Machado, H Wu, T Kusaba, K Hoeft, RK Schneider, BD Humphreys (2018)
Parabiosis and single-cell RNA sequencing reveal a limited contribution of monocytes to myofibroblasts in kidney fibrosis, 3
S Neelisetty, C Alford, K Reynolds, L Woodbury, S Nlandu-Khodo, H Yang, AB Fogo, CM Hao, RC Harris, R Zent, L Gewin (2015)
Renal fibrosis is not reduced by blocking transforming growth factor-beta signaling in matrix-producing interstitial cells, 88
I Hirahara, E Kusano, T Imai, Y Morishita, M Inoue, T Akimoto, O Saito, S Muto, D Nagata (2015)
Effluent tenascin-c levels reflect peritoneal deterioration in peritoneal dialysis: MAJOR IN PD Study, 2015
X Tian, H Gan, Y Zeng, H Zhao, R Tang, Y Xia (2018)
Inhibition of semaphorin-3a suppresses lipopolysaccharide-induced acute kidney injury, 96
SA Pileri, G Roncador, C Ceccarelli, M Piccioli, A Briskomatis, E Sabattini, S Ascani, D Santini, PP Piccaluga, O Leone, S Damiani, C Ercolessi, F Sandri, F Pieri, L Leoncini, B Falini (1997)
Antigen retrieval techniques in immunohistochemistry: comparison of different methods, 183
P. Aggarwal, D. Verón, David Thomas, D. Siegel, G. Moeckel, M. Kashgarian, A. Tufro (2014)
Semaphorin3a Promotes Advanced Diabetic NephropathyDiabetes, 64
AL Kolodkin, DJ Matthes, CS Goodman (1993)
The semaphorin genes encode a family of transmembrane and secreted growth cone guidance molecules, 75
K Deacon, JL Blank (1997)
Characterization of the mitogen-activated protein kinase kinase 4 (MKK4)/c-Jun NH2-terminal kinase 1 and MKK3/p38 pathways regulated by MEK kinases 2 and 3. MEK kinase 3 activates MKK3 but does not cause activation of p38 kinase in vivo, 272
T Toyofuku, H Kikutani (2007)
Semaphorin signaling during cardiac development, 600
I Loeffler (2019)
MKP2 suppresses TGF-beta1-induced epithelial-to-mesenchymal transition through JNK inhibition, 133
T. Toyofuku, Junko Yoshida, Tamiko Sugimoto, Hong Zhang, A. Kumanogoh, M. Hori, H. Kikutani (2005)
FARP2 triggers signals for Sema3A-mediated axonal repulsionNature Neuroscience, 8
H Takamatsu, T Okuno, A Kumanogoh (2010)
Regulation of immune cell responses by semaphorins and their receptors, 7
BR Conway, ED O'Sullivan, C Cairns, J O'Sullivan, DJ Simpson, A Salzano, K Connor, P Ding, D Humphries, K Stewart, O Teenan, R Pius, NC Henderson, C Benezech, P Ramachandran, D Ferenbach, J Hughes, T Chandra, L Denby (2020)
Kidney Single-cell atlas reveals myeloid heterogeneity in progression and regression of kidney disease, 31
A Inoue-Torii, S Kitamura, J Wada, K Tsuji, H Makino (2017)
The level of urinary semaphorin3A is associated with disease activity in patients with minimal change nephrotic syndrome, 10
F. Guan, Guillermo Villegas, Jason Teichman, P. Mundel, A. Tufro (2006)
Autocrine class 3 semaphorin system regulates slit diaphragm proteins and podocyte survival.Kidney international, 69 9
J Kanellis, FY Ma, R Kandane-Rathnayake, JP Dowling, KR Polkinghorne, BL Bennett, GC Friedman, DJ Nikolic-Paterson (2010)
JNK signalling in human and experimental renal ischaemia/reperfusion injury, 25
V Danelon, R Goldner, E Martinez, I Gokhman, K Wang, A Yaron, TS Tran (2020)
Modular and distinct plexin-A4/FARP2/Rac1 signaling controls dendrite morphogenesis, 40
GH Tesch, FY Ma, DJ Nikolic-Paterson (2016)
ASK1: a new therapeutic target for kidney disease, 311
A Cuenda (2000)
Mitogen-activated protein kinase kinase 4 (MKK4), 32
SI Kim, ME Choi (2012)
TGF-beta-activated kinase-1: new insights into the mechanism of TGF-beta signaling and kidney disease, 31
Lars Klareskog (2011)
GI-REASONS: A Novel 6-Month, Prospective, Randomized, Open-Label, Blinded Endpoint (PROBE) TrialThe American Journal of Gastroenterology, 108
M Omoto, S Yoshida, H Miyashita, T Kawakita, K Yoshida, A Kishino, T Kimura, S Shibata, K Tsubota, H Okano, S Shimmura (2012)
The semaphorin 3A inhibitor SM-345431 accelerates peripheral nerve regeneration and sensitivity in a murine corneal transplantation model, 7
AB Farris, RB Colvin (2012)
Renal interstitial fibrosis: mechanisms and evaluation, 21
MK Kim, YI Maeng, WJ Sung, HK Oh, JB Park, GS Yoon, CH Cho, KK Park (2013)
The differential expression of TGF-beta1, ILK and wnt signaling inducing epithelial to mesenchymal transition in human renal fibrogenesis: an immunohistochemical study, 6
Shinjiro Kaneko, A. Iwanami, M. Nakamura, A. Kishino, K. Kikuchi, S. Shibata, H. Okano, Takeshi Ikegami, Ayako Moriya, Osamu Konishi, C. Nakayama, K. Kumagai, Toru Kimura, Yasufumi Sato, Y. Goshima, M. Taniguchi, Mamoru Ito, Zhigang He, Y. Toyama, Hideyuki Okano (2006)
A selective Sema3A inhibitor enhances regenerative responses and functional recovery of the injured spinal cordNature Medicine, 12
Y Kida, K Asahina, H Teraoka, I Gitelman, T Sato (2007)
Twist relates to tubular epithelial-mesenchymal transition and interstitial fibrogenesis in the obstructed kidney, 55
E El Eter (2013)
NQDI 1, an inhibitor of ASK1 attenuates acute ischemic renal injury by modulating oxidative stress and cell death, 11
L Ning, S Li, J Gao, L Ding, C Wang, W Chen, G Shan, F Zhang, J Yu, G Xu (2019)
Tenascin-C is increased in inflammatory bowel disease and is associated with response to infliximab therapy, 2019
K. Kumagai, Nobuo Hosotani, K. Kikuchi, Toru Kimura, I. Saji (2003)
Xanthofulvin, a novel semaphorin inhibitor produced by a strain of Penicillium.The Journal of antibiotics, 56 7
M Iwano, D Plieth, TM Danoff, C Xue, H Okada, EG Neilson (2002)
Evidence that fibroblasts derive from epithelium during tissue fibrosis, 110
(1999)
Unified nomenclature for the semaphorins/collapsins, 97
NV Kukekov, Z Xu, LA Greene (2006)
Direct interaction of the molecular scaffolds POSH and JIP is required for apoptotic activation of JNKs, 281
J Xia, T Worzfeld (2016)
Semaphorins and plexins in kidney disease, 132
M Iwano (2010)
EMT and TGF-beta in renal fibrosis, 2
KI Jeon, K Nehrke, KR Huxlin (2020)
Semaphorin 3A potentiates the profibrotic effects of transforming growth factor-beta1 in the cornea, 521
Y Liu (2010)
New insights into epithelial-mesenchymal transition in kidney fibrosis, 21
D Hammaker, GS Firestein (2010)
“Go upstream, young man”: lessons learned from the p38 saga, 69
T Inoue, A Umezawa, T Takenaka, H Suzuki, H Okada (2015)
The contribution of epithelial-mesenchymal transition to renal fibrosis differs among kidney disease models, 87
N Takegahara, H Takamatsu, T Toyofuku, T Tsujimura, T Okuno, K Yukawa, M Mizui, M Yamamoto, DV Prasad, K Suzuki, M Ishii, K Terai, M Moriya, Y Nakatsuji, S Sakoda, S Sato, S Akira, K Takeda, M Inui, T Takai, M Ikawa, M Okabe, A Kumanogoh, H Kikutani (2006)
Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis, 8
F Strutz, H Okada, CW Lo, T Danoff, RL Carone, JE Tomaszewski, EG Neilson (1995)
Identification and characterization of a fibroblast marker: FSP1, 130
K Tsuji, S Kitamura, Y Sang, K Fukushima, J Wada (2020)
Adult kidney stem/progenitor cells contribute to regeneration through the secretion of trophic factors, 46
Punithavathi Ranganathan, Calpurnia Jayakumar, Riyaz Mohamed, N. Weintraub, G. Ramesh (2014)
Semaphorin 3A inactivation suppresses ischemia-reperfusion-induced inflammation and acute kidney injury.American journal of physiology. Renal physiology, 307 2
Y Sang, K Tsuji, A Inoue-Torii, K Fukushima, S Kitamura, J Wada (2020)
Semaphorin3A-inhibitor ameliorates doxorubicin-induced podocyte injury, 21
W Kriz, B Kaissling, M Le Hir (2011)
Epithelial-mesenchymal transition (EMT) in kidney fibrosis: fact or fantasy?, 121
QG Zhang, R Wang, D Han, Y Dong, DW Brann (2009)
Role of Rac1 GTPase in JNK signaling and delayed neuronal cell death following global cerebral ischemia, 1265
H Wu, Y Kirita, EL Donnelly, BD Humphreys (2019)
Advantages of single-nucleus over single-cell RNA sequencing of adult kidney: rare cell types and novel cell states revealed in fibrosis, 30
S. Kim, Mary Choi (2012)
TGF-β-activated kinase-1: New insights into the mechanism of TGF-β signaling and kidney diseaseKidney Research and Clinical Practice, 31
K Suzuki, A Kumanogoh, H Kikutani (2008)
Semaphorins and their receptors in immune cell interactions, 9
Liang Zhang, Shinjiro Kaneko, K. Kikuchi, A. Sano, M. Maeda, A. Kishino, S. Shibata, Masahiko Mukaino, Y. Toyama, Meigen Liu, Toru Kimura, H. Okano, M. Nakamura (2014)
Rewiring of regenerated axons by combining treadmill training with semaphorin3A inhibitionMolecular Brain, 7
N Frangogiannis (2020)
Transforming growth factor-beta in tissue fibrosis, 217
PZ Gerczuk, DG Breckenridge, JT Liles, GR Budas, JC Shryock, L Belardinelli, RA Kloner, W Dai (2012)
An apoptosis signal-regulating kinase 1 inhibitor reduces cardiomyocyte apoptosis and infarct size in a rat ischemia-reperfusion model, 60
N Picard, O Baum, A Vogetseder, B Kaissling, M Le Hir (2008)
Origin of renal myofibroblasts in the model of unilateral ureter obstruction in the rat, 130
H Ichijo, E Nishida, K Irie, P ten Dijke, M Saitoh, T Moriguchi, M Takagi, K Matsumoto, K Miyazono, Y Gotoh (1997)
Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways, 275
W Xu, Z Yang, N Lu (2015)
A new role for the PI3K/Akt signaling pathway in the epithelial-mesenchymal transition, 9
GH Tesch, FY Ma, Y Han, JT Liles, DG Breckenridge, DJ Nikolic-Paterson (2015)
ASK1 inhibitor halts progression of diabetic nephropathy in Nos3-deficient mice, 64
B. Humphreys (2018)
Mechanisms of Renal Fibrosis.Annual review of physiology, 80
K Grynberg, FY Ma, DJ Nikolic-Paterson (2017)
The JNK signaling pathway in renal fibrosis, 8
B Sutariya, D Jhonsa, MN Saraf (2016)
TGF-beta: the connecting link between nephropathy and fibrosis, 38
A. Ben-Zvi, Zohar Yagil, Yamit Hagalili, Hagit Klein, Omer Lerman, O. Behar (2006)
Semaphorin 3A and neurotrophins: a balance between apoptosis and survival signaling in embryonic DRG neuronsJournal of Neurochemistry, 96
TJ Liu, JL Guo, HK Wang, X Xu (2018)
Semaphorin-7A contributes to growth, migration and invasion of oral tongue squamous cell carcinoma through TGF-beta-mediated EMT signaling pathway, 22
A Ijaz, T Tejada, P Catanuto, X Xia, SJ Elliot, O Lenz, A Jauregui, MO Saenz, RD Molano, A Pileggi, C Ricordi, A Fornoni (2009)
Inhibition of C-jun N-terminal kinase improves insulin sensitivity but worsens albuminuria in experimental diabetes, 75
Hanni Menn-Josephy, Carol Lee, A. Nolin, Marta Christov, D. Rybin, J. Weinberg, J. Henderson, R. Bonegio, A. Havasi (2016)
Renal Interstitial Fibrosis: An Imperfect Predictor of Kidney Disease Progression in Some Patient CohortsAmerican Journal of Nephrology, 44
K Kikuchi, A Kishino, O Konishi, K Kumagai, N Hosotani, I Saji, C Nakayama, T Kimura (2003)
In vitro and in vivo characterization of a novel semaphorin 3A inhibitor, SM-216289 or xanthofulvin, 278
Renal fibrosis is the common pathological pathway in progressive renal diseases. In the study, we analyzed the roles of Semaphorin 3A (SEMA3A) on renal fibrosis and the effect of SEMA3A-inhibitor (SEMA3A-I) using unilateral ureteral obstruction (UUO) mouse model. The expression of SEMA3A in the proximal tubulus and neuropilin-1 (NRP1), a recepor of SEMA3A, in fibloblast and tubular cells were increased in the UUO kidneys. The increased expression of myofibroblast marker tenascin-C and fibronection as well as renal fibrosis were increased in UUO kidneys, all of which were ameliorated by SEMA3A-I. In addition, c-Jun N-terminal kinase (JNK) signaling pathway known as the target of SEMA3A signaling, was activated in proximal tubular cells and fibroblast cells after UUO surgery while SEMA3A-I significantly attenuated the activation. In vitro, treatments with SEMA3A as well as transforming growth factor-β1 (TGF-β1) in human proximal tubular cells lost epithelial cell characters while SEMA3A-I significantly ameliorated this transformation. JNK inhibitor, SP600125, partially reversed SEMA3A and TGF-β1-induced cell transformation, indicating that JNK signaling is involved in SEMA3A-induced renal fibrosis. In addition, the treatment with SEMA3A in fibroblast cells activated the expression of tenascin-C, collagen type I and fibronection, indicating that SEMA3A may accelerate renal fibrosis through the activation of fibroblast cells. The analysis of human data revealed the positive correlation between urinary SEMA3A and urinary N-acetyl-β-D-glucosaminidase, indicating the association between SEMA3A and tubular injury. In conclusion, SEMA3A signaling is involved in renal fibrosis through JNK signaling pathway and SEMA3A-I might be the therapeutic option for protecting from renal fibrosis.
American Journal of Physiology-Renal Physiology – The American Physiological Society
Published: Dec 1, 2021
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