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Relapse in steroid-sensitive nephrotic syndrome: are extracellular vesicles the missing link?

Relapse in steroid-sensitive nephrotic syndrome: are extracellular vesicles the missing link? Am J Physiol Renal Physiol 321: F656–F658, 2021. First published September 27, 2021; doi:10.1152/ajprenal.00349.2021 EDITORIAL Relapse in steroid-sensitive nephrotic syndrome: are extracellular vesicles the missing link? 1,2 2 Robert L. Myette and Dylan Burger Division of Nephrology, Department of Pediatrics, Children’s Hospital of Eastern Ontario, University of Ottawa, Ottawa, Ontario, Canada and Kidney Research Centre, Department of Cellular and Molecular Medicine, The Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada Pediatric nephrotic syndrome (NS) is a podocytopathy and sex-matched controls. These studies focused on the use of represents one of the most common forms of glomerular uEVs as biomarkers; however, studies focused on disease dysfunction in children (1). Idiopathic NS is the most com- mechanisms involving plasma EVs have been lacking. mon form and comprises glomerular foot process effacement In an article recently published in the American Journal of evident on renal biopsy. Children with idiopathic NS have Physiology-Renal Physiology,Eroglu et al. (6)studied plasma massive proteinuria with subsequent hypoalbuminemia, EVs from 20 children with steroid-sensitive NS (SSNS) in both and edema. This can lead to secondary issues, including relapse and remission stage and compared those EVs with 10 hypercholesterolemia, increased risk of infection and venous healthy controls http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Physiology-Renal Physiology The American Physiological Society

Relapse in steroid-sensitive nephrotic syndrome: are extracellular vesicles the missing link?

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ISSN
1931-857x
eISSN
1522-1466
DOI
10.1152/ajprenal.00349.2021
Publisher site
See Article on Publisher Site

Abstract

Am J Physiol Renal Physiol 321: F656–F658, 2021. First published September 27, 2021; doi:10.1152/ajprenal.00349.2021 EDITORIAL Relapse in steroid-sensitive nephrotic syndrome: are extracellular vesicles the missing link? 1,2 2 Robert L. Myette and Dylan Burger Division of Nephrology, Department of Pediatrics, Children’s Hospital of Eastern Ontario, University of Ottawa, Ottawa, Ontario, Canada and Kidney Research Centre, Department of Cellular and Molecular Medicine, The Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada Pediatric nephrotic syndrome (NS) is a podocytopathy and sex-matched controls. These studies focused on the use of represents one of the most common forms of glomerular uEVs as biomarkers; however, studies focused on disease dysfunction in children (1). Idiopathic NS is the most com- mechanisms involving plasma EVs have been lacking. mon form and comprises glomerular foot process effacement In an article recently published in the American Journal of evident on renal biopsy. Children with idiopathic NS have Physiology-Renal Physiology,Eroglu et al. (6)studied plasma massive proteinuria with subsequent hypoalbuminemia, EVs from 20 children with steroid-sensitive NS (SSNS) in both and edema. This can lead to secondary issues, including relapse and remission stage and compared those EVs with 10 hypercholesterolemia, increased risk of infection and venous healthy controls

Journal

American Journal of Physiology-Renal PhysiologyThe American Physiological Society

Published: Nov 1, 2021

References