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Recent advances in renal epithelial transport

Recent advances in renal epithelial transport Am J Physiol Renal Physiol 316: F274–F276, 2019; First published December 5, 2018; doi:10.1152/ajprenal.00510.2018. EDITORIAL FOCUS Anita T. Layton Department of Applied Mathematics and School of Pharmacy, University of Waterloo, Waterloo, Ontario, Canada; and Departments of Mathematics, Biomedical Engineering, and Medicine, Duke University, Durham, North Carolina Submitted 30 October 2018; accepted in final form 4 December 2018 Besides the excretion of metabolic wastes, the kidneys regulate Canagliflozin and its effect on plasma uremic toxins were the balance of sodium, potassium, and acid-base (15). Impair- the focus of a study by Mishima et al. (11). In addition to the inhibition of SGLT2, canagliflozin also exerts a modest inhib- ment of certain transport functions is known to play an impor- itory effect on SGLT1. Because SGLT1 is expressed in the S3 tant role in the pathogenesis of diseases such as proteinuria and segment as well as the intestines, canagliflozin may influence hypertension. But despite decades of research, aspects of renal the gastrointestinal environment, which in turn affects the epithelial transport mechanisms have yet to be fully elucidated. accumulation of uremic toxins. Indeed, Mishima et al. showed This editorial focus will highlight recent advances in our that in mice, canagliflozin exerts intestinal http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Physiology-Renal Physiology The American Physiological Society

Recent advances in renal epithelial transport

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References (22)

ISSN
1931-857x
eISSN
1522-1466
DOI
10.1152/ajprenal.00510.2018
Publisher site
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Abstract

Am J Physiol Renal Physiol 316: F274–F276, 2019; First published December 5, 2018; doi:10.1152/ajprenal.00510.2018. EDITORIAL FOCUS Anita T. Layton Department of Applied Mathematics and School of Pharmacy, University of Waterloo, Waterloo, Ontario, Canada; and Departments of Mathematics, Biomedical Engineering, and Medicine, Duke University, Durham, North Carolina Submitted 30 October 2018; accepted in final form 4 December 2018 Besides the excretion of metabolic wastes, the kidneys regulate Canagliflozin and its effect on plasma uremic toxins were the balance of sodium, potassium, and acid-base (15). Impair- the focus of a study by Mishima et al. (11). In addition to the inhibition of SGLT2, canagliflozin also exerts a modest inhib- ment of certain transport functions is known to play an impor- itory effect on SGLT1. Because SGLT1 is expressed in the S3 tant role in the pathogenesis of diseases such as proteinuria and segment as well as the intestines, canagliflozin may influence hypertension. But despite decades of research, aspects of renal the gastrointestinal environment, which in turn affects the epithelial transport mechanisms have yet to be fully elucidated. accumulation of uremic toxins. Indeed, Mishima et al. showed This editorial focus will highlight recent advances in our that in mice, canagliflozin exerts intestinal

Journal

American Journal of Physiology-Renal Physiology – The American Physiological Society

Published: Feb 1, 2019

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