Access the full text.
Sign up today, get DeepDyve free for 14 days.
S. DiGiovanni, S. Nielsen, E. Christensen, M. Knepper (1994)
Regulation of collecting duct water channel expression by vasopressin in Brattleboro rat.Proceedings of the National Academy of Sciences of the United States of America, 91 19
G. Lindop, P. Padfield (1975)
The renal pathology in a case of lithium-induced diabetes insipidus.Journal of Clinical Pathology, 28
T Katsura, CE Gustafson, DA Ausiello, D Brown (1997)
Protein kinase A phosphorylation is involved in regulated exocytosis of aquaporin-2 in transfected LLC-PK1 cells, 272
W. Kim, S. Nam, Arum Choi, Yu-mi Kim, S. Park, Hong Kim, Hyang Kim, K. Han, Chul-woo Yang, Myung-Shik Lee, Yong Kim, Jin Kim (2019)
Atg7-dependent canonical autophagy regulates the degradation of aquaporin 2 in prolonged hypokalemiaScientific Reports, 9
W. Rosenthal, A. Seibold, A. Antaramián, M. Lonergan, M. Arthus, G. Hendy, M. Birnbaumer, D. Bichet (1992)
Molecular identification of the gene responsible for congenital nephrogenic diabetes insipidusNature, 359
A. Iervolino, Federica Prosperi, Luigi Motte, Federica Petrillo, M. Spagnuolo, M. D'Acierno, Sabrina Siccardi, A. Perna, B. Christensen, S. Frische, G. Capasso, F. Trepiccione (2020)
Potassium depletion induces cellular conversion in the outer medullary collecting duct altering Notch signaling pathwayScientific Reports, 10
GW Rutecki, JW Cox, GW Robertson, LL Francisco, TF Ferris (1982)
Urinary concentrating ability and antidiuretic hormone responsiveness in the potassium-depleted dog, 100
H Amlal, CM Krane, Q Chen, M Soleimani (2000)
Early polyuria and urinary concentrating defect in potassium deprivation, 279
H. Yalamanchili, S. Calp-Inal, X. Zhou, D. Choudhury (2018)
Hypokalemic NephropathyKidney International Reports, 3
Fumiaki Ando, E. Sohara, T. Morimoto, N. Yui, Naohiro Nomura, Eriko Kikuchi, Daiei Takahashi, Takayasu Mori, A. Vandewalle, T. Rai, S. Sasaki, Y. Kondo, S. Uchida (2016)
Wnt5a induces renal AQP2 expression by activating calcineurin signalling pathwayNature Communications, 7
S. Tingskov, H. Mutsaers, R. Nørregaard (2020)
Estrogen regulates aquaporin-2 expression in the kidney.Vitamins and hormones, 112
Y Matsumura, S Uchida, T Rai, S Sasaki, F Marumo (1997)
Transcriptional regulation of aquaporin-2 water channel gene by cAMP, 8
S. Walter, A. Shore, D. Shirley (1988)
Effect of potassium depletion on renal tubular function in the rat.Clinical science, 75 6
M. Elkjaer, T. Kwon, Weidong Wang, J. Nielsen, M. Knepper, J. Frøkiaer, S. Nielsen (2002)
Altered expression of renal NHE3, TSC, BSC-1, and ENaC subunits in potassium-depleted rats.American journal of physiology. Renal physiology, 283 6
Catherine Kim, A. Ricardo, E. Boyko, C. Christophi, M. Temprosa, K. Watson, X. Pi-Sunyer, R. Kalyani (2018)
Sex Hormones and Measures of Kidney Function in the Diabetes Prevention Program Outcomes StudyThe Journal of Clinical Endocrinology & Metabolism, 104
BE McFarlin, Y Chen, TS Priver, DL Ralph, A Mercado, G Gamba, MS Madhur, AA McDonough (2020)
Coordinate adaptations of skeletal muscle and kidney to maintain extracellular [K+] during K+-deficient diet, 319
D. Henry (2015)
In The Clinic: Hyponatremia.Annals of internal medicine, 163 3
A Manitius, H Levitin, D Beck, FH Epstein (1960)
On the mechanism of impairment of renal concentrating ability in potassium deficiency, 39
M Peters, N Jeck, S Reinalter, A Leonhardt, B Tonshoff, GG Klaus, M Konrad, HW Seyberth (2002)
Clinical presentation of genetically defined patients with hypokalemic salt-losing tubulopathies, 112
BK Kishore, JM Terris, MA Knepper (1996)
Quantitation of aquaporin-2 abundance in microdissected collecting ducts: axial distribution and control by AVP, 271
N. Goswami, J. Reichmuth, Annarita Mise, B. Brix, A. Roessler, M. Centrone, M. Ranieri, Annamaria Russo, N. Santo, G. Tamma, F. Sasso, G. Valenti (2018)
Comparison between men and women of volume regulating hormones and aquaporin-2 excretion following graded central hypovolemiaEuropean Journal of Applied Physiology, 119
M Greenlee, CS Wingo, AA McDonough, J-H Youn, BC Kone (2009)
Narrative review: evolving concepts in potassium homeostasis and hypokalemia, 150
JP Kulka, CM Pearson, SL Robins (1950)
A distinctive vacuolar nephropathy associated with intestinal disease, 26
J Loffing (2004)
Paradoxical antidiuretic effect of thiazides in diabetes insipidus: another piece in the puzzle, 15
N. Beck, S. Webster (1976)
Impaired urinary concentrating ability and cyclic AMP in K+-depleted rat kidney.The American journal of physiology, 231 4
Ju-Young Jung, K. Madsen, K. Han, Chul-Woo Yang, M. Knepper, J. Sands, Jin Kim (2003)
Expression of urea transporters in potassium-depleted mouse kidney.American journal of physiology. Renal physiology, 285 6
JL Vinas, CJ Porter, A Douvris, M Spence, A Gutsol, JA Zimpelmann, K Tailor, PA Campbell, KD Burns (2020)
Sex diversity in proximal tubule and endothelial gene expression in mice with ischemic acute kidney injury, 134
S. Khositseth, P. Uawithya, P. Somparn, Komgrid Charngkaew, Nattakan Thippamom, J. Hoffert, F. Saeed, D. Payne, Shu-Hui Chen, R. Fenton, T. Pisitkun, T. Pisitkun (2015)
Autophagic degradation of aquaporin-2 is an early event in hypokalemia-induced nephrogenic diabetes insipidusScientific Reports, 5
PR Uldall, AG Awad, WO McCormick, LB Carter, T Gonsick, CL Grass, MI Kugelmass (1981)
Renal function in patients receiving long-term lithium therapy, 124
KH Raymond, KK Davidson, TD McKinney (1985)
In vivo and in vitro studies of urinary concentrating ability in potassium-depleted rabbits, 76
D. Bockenhauer, D. Bichet (2013)
Inherited secondary nephrogenic diabetes insipidus: concentrating on humans.American journal of physiology. Renal physiology, 304 8
R. Morris, E. Hoorn, M. Knepper (2006)
Hypokalemia in a mouse model of Gitelman's syndrome.American journal of physiology. Renal physiology, 290 6
Cary Boyd-Shiwarski, C. Weaver, Rebecca Beacham, Daniel Shiwarski, K. Connolly, Lubika Nkashama, Stephanie Mutchler, Shawn Griffiths, Sophia Knoell, Romano Sebastiani, Evan Ray, Allison Marciszyn, A. Subramanya (2020)
Effects of extreme potassium stress on blood pressure and renal tubular sodium transport.American journal of physiology. Renal physiology
Takashi Matsuda, T. Hiyama, F. Niimura, T. Matsusaka, A. Fukamizu, Kenta Kobayashi, Kazuto Kobayashi, M. Noda (2016)
Distinct neural mechanisms for the control of thirst and salt appetite in the subfornical organNature Neuroscience, 20
H. Moeller, M. Knepper, R. Fenton (2009)
Serine 269 phosphorylated aquaporin-2 is targeted to the apical membrane of collecting duct principal cells.Kidney international, 75 3
A. Terker, Chong Zhang, J. McCormick, Rebecca Lazelle, Chengbiao Zhang, Nicholas Meermeier, Dominic Siler, Hae Park, Yi Fu, D. Cohen, A. Weinstein, Wen‐Hui Wang, Chao‐ling Yang, D. Ellison (2015)
Potassium modulates electrolyte balance and blood pressure through effects on distal cell voltage and chloride.Cell metabolism, 21 1
ID Weiner, CS Wingo (1997)
Hypokalemia–consequences, causes, and correction, 8
A Seibold, P Brabet, W Rosenthal, M Birnbaumer (1992)
Structure and chromosomal localization of the human antidiuretic hormone receptor gene, 51
LE Earley, J Orloff (1962)
The mechanism of antidiuresis associated with the administration of hydrochlorothiazide to patients with vasopressin-resistant diabetes insipidus, 41
PI Nedvetsky, V Tabor, G Tamma, S Beulshausen, P Skroblin, A Kirschner, K Mutig, M Boltzen, O Petrucci, A Vossenkamper, B Wiesner, S Bachmann, W Rosenthal, E Klussmann (2010)
Reciprocal regulation of aquaporin-2 abundance and degradation by protein kinase A and p38-MAP kinase, 21
P. Welling (2016)
Roles and Regulation of Renal K Channels.Annual review of physiology, 78
M Goldberg (1981)
Hyponatremia, 65
Turgay Saritas, Victor Puelles, X. Su, J. McCormick, P. Welling, D. Ellison (2018)
Optical Clearing in the Kidney Reveals Potassium-Mediated Tubule RemodelingCell reports, 25
Pei Chen, J. Guzman, P. Leong, Li Yang, A. Perianayagam, E. Babilonia, Jennifer Ho, J. Youn, Wen Wang, A. McDonough (2006)
Modest dietary K+ restriction provokes insulin resistance of cellular K+ uptake and phosphorylation of renal outer medulla K+ channel without fall in plasma K+ concentration.American journal of physiology. Cell physiology, 290 5
U Hasler, V Leroy, US Jeon, R Bouley, M Dimitrov, JA Kim, D Brown, HM Kwon, PY Martin, E Feraille (2008)
NF-κB modulates aquaporin-2 transcription in renal collecting duct principal cells, 283
D Marples, J Frokiaer, J Dorup, MA Knepper, S Nielsen (1996)
Hypokalemia-induced downregulation of aquaporin-2 water channel expression in rat kidney medulla and cortex, 97
G-H Kim, JW Lee, YK Oh, HR Chang, KW Joo, KY Na, J-H Earm, MA Knepper, JS Han (2004)
Antidiuretic effect of hydrochlorothiazide in lithium-induced nephrogenic diabetes insipidus is associated with upregulation of aquaporin-2, Na-Cl co-transporter, and epithelial sodium channel, 15
S. Smith, T. Lasater (1950)
A Diabetes Insipidus-like Condition Produced in Dogs by a Potassium Deficient DietProceedings of the Society for Experimental Biology and Medicine, 74
JP Mallie, DG Bichet, ML Halperin (1997)
Effective water clearance and tonicity balance: the excretion of water revisited, 20
BM Christensen, M Zelenina, A Aperia, S Nielsen (2000)
Localization and regulation of PKA-phosphorylated AQP2 in response to V2-receptor agonist/antagonist treatment, 278
S Reungjui, CA Roncal, W Sato, OY Glushakova, BP Croker, S-I Suga, X Ouyang, K Tungsanga, T Nakagawa, RJ Johnson, W Mu (2008)
Hypokalemic nephropathy is associated with impaired angiogenesis, 19
J. Hadchouel, D. Ellison, G. Gamba (2016)
Regulation of Renal Electrolyte Transport by WNK and SPAK-OSR1 Kinases.Annual review of physiology, 78
D. Wysowski, C. Kornegay, P. Nourjah, A. Trontell (2003)
Sex and age differences in serum potassium in the United States.Clinical chemistry, 49 1
PR Grimm, R Coleman, E Delpire, PA Welling (2017)
Constitutively active SPAK causes hyperkalemia by activating NCC and remodeling distal tubules, 28
R. Luke, R. Lyerly, J. Anderson, J. Galla, T. Kotchen (1982)
Effect of potassium depletion on renin release.Kidney international, 21 1
JK Kim, BA Jackson, RM Edwards, TP Dousa (1982)
Effect of potassium depletion on the vasopressin-sensitive cyclic AMP system in rat outer medullary tubules, 99
A. Nair, Wei Yanhong, T. Paunescu, R. Bouley, Dennis Brown (2019)
Sex-dependent differences in water homeostasis in wild-type and V-ATPase B1-subunit deficient micePLoS ONE, 14
SI Suga, MI Phillips, PE Ray, JA Raleigh, CP Vio, YG Kim, M Mazzali, KL Gordon, J Hughes, RJ Johnson (2001)
Hypokalemia induces renal injury and alterations in vasoactive mediators that favor salt sensitivity, 281
Walter Hollander, Robert Winters, Franklin Williams, John Bradley, Jean Oliver, Louis Welt (1957)
Defect in the renal tubular reabsorption of water associated with potassium depletion in rats.The American journal of physiology, 189 3
D. Benos, Edward Abraham, Peter Wagner, Megan Greenlee, C. Wingo, A. McDonough, J. Youn, B. Kone
Physiology in Medicine: a Series of Articles Linking Medicine with Science Physiology in Medicine: Narrative Review: Evolving Concepts in Potassium Homeostasis and Hypokalemia Normal Potassium Balance and Renal Potassium Excretion
A. McDonough, C. Thompson, J. Youn (2002)
Skeletal muscle regulates extracellular potassium.American journal of physiology. Renal physiology, 282 6
K. Fushimi, S. Sasaki, F. Marumo (1997)
Phosphorylation of Serine 256 Is Required for cAMP-dependent Regulatory Exocytosis of the Aquaporin-2 Water Channel*The Journal of Biological Chemistry, 272
Zhijian Wang, Peng Sun, Wenming Xing, Chu-Yang Pan, Daohong Lin, Wen‐Hui Wang (2010)
Decrease in dietary K intake stimulates the generation of superoxide anions in the kidney and inhibits K secretory channels in the CCD.American journal of physiology. Renal physiology, 298 6
D. Shirley, S. Walter, J. Laycock (1982)
The antidiuretic effect of chronic hydrochlorothiazide treatment in rats with diabetes insipidus: renal mechanisms.Clinical science, 63 6
E-Y Park, W-Y Kim, Y-M Kim, J-H Lee, K-H Han, I-D Weiner, J Kim (2012)
Proposed mechanism in the change of cellular composition in the outer medullary collecting duct during potassium homeostasis, 27
E. Tahaei, R. Coleman, Turgay Saritas, D. Ellison, P. Welling (2020)
Distal Convoluted Tubule Sexual Dimorphism Revealed by Advanced 3D-Imaging.American journal of physiology. Renal physiology
Allan-Hermann Pool, Tongtong Wang, David Stafford, Rebecca Chance, Sangjun Lee, J. Ngai, Yuki Oka (2020)
The cellular basis of distinct thirst modalitiesNature, 588
E. Nordøy, D. Stijfhoorn, A. Råheim, A. Blix (1992)
Water flux and early signs of entrance into phase III of fasting in grey seal pups.Acta physiologica Scandinavica, 144 4
S. Sinha, N. Dwivedi, Shixin Tao, A. Jamadar, Vijayakumar Kakade, M. Neil, R. Weiss, Jonathan Enders, J. Calvet, S. Thomas, Reena Rao (2019)
Targeting the Vasopressin Type 2 Receptor for Renal Cell Carcinoma TherapyOncogene, 39
Teddy Musselman, Zheng Zhang, S. Masilamani (2010)
Differential regulation of the bumetanide-sensitive cotransporter (NKCC2) by ovarian hormonesSteroids, 75
L. Xie, J. Hoffert, C. Chou, Ming-Jiun Yu, T. Pisitkun, M. Knepper, R. Fenton (2010)
Quantitative analysis of aquaporin-2 phosphorylation.American journal of physiology. Renal physiology, 298 4
T Berl, SL Linas, GA Aisenbrey, RJ Anderson (1977)
On the mechanism of polyuria in potassium depletion: the role of polydipsia, 60
LC Veiras, ACC Girardi, J Curry, L Pei, DL Ralph, A Tran, RC Castelo-Branco, N Pastor-Soler, CT Arranz, ASL Yu, AA McDonough (2017)
Sexual dimorphic pattern of renal transporters and electrolyte homeostasis, 28
Brandon McFarlin, Yuhan Chen, Taylor Priver, D. Ralph, A. Mercado, G. Gamba, M. Madhur, A. McDonough (2020)
Coordinate adaptations of skeletal muscle and kidney to adjust extracellular [K+] during K+ deficient diet in mice.American journal of physiology. Cell physiology
J. Sullivan, E. Gillis (2017)
Sex and gender differences in hypertensive kidney injury.American journal of physiology. Renal physiology, 313 4
J. Hoffert, T. Pisitkun, Guanghui Wang, Rong‐Fong Shen, M. Knepper (2006)
Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites.Proceedings of the National Academy of Sciences of the United States of America, 103 18
Luciano Mendoza, Kelly Hyndman (2019)
The contribution of collecting duct NOS1 to the concentrating mechanisms in male and female mice.American journal of physiology. Renal physiology
A Datta, C-R Yang, K Limbutara, C-L Chou, MM Rinschen, V Raghuram, MA Knepper (2020)
PKA-independent vasopressin signaling in renal collecting duct, 34
D. Bolignano, M. Medici, G. Coppolino, M. Sciortino, F. Merlo, S. Campo, Valentina Donato, A. Venuti, A. Sturiale, D. Zaccaria, A. Buemi, A. Lacquaniti, M. Buemi (2010)
Aquaretic inhibits renal cancer proliferation: Role of vasopressin receptor-2 (V2-R).Urologic oncology, 28 6
Jae Lee, M. Alsady, C. Chou, Theun Groot, P. Deen, M. Knepper, C. Ecelbarger (2018)
Single-tubule RNA-Seq uncovers signaling mechanisms that defend against hyponatremia in SIADH.Kidney international, 93 1
Min Gao, R. Cao, Shengnan Du, Xiao Jia, Senfeng Zheng, Shizheng Huang, Qifei Han, Jia Liu, Xiaoyan Zhang, Yi-fei Miao, Jihong Kang, J. Gustafsson, Y. Guan (2015)
Disruption of prostaglandin E2 receptor EP4 impairs urinary concentration via decreasing aquaporin 2 in renal collecting ductsProceedings of the National Academy of Sciences, 112
J. Morello, D. Bichet (1998)
Nephrogenic diabetes insipidus.The American journal of medicine, 105 5
C. Ortiz, D. Costa, B. Boeuf (1978)
Water and Energy Flux in Elephant Seal Pups Fasting under Natural ConditionsPhysiological Zoology, 51
The association between diabetes insipidus (DI) and chronic dietary potassium deprivation is well known but it remains uncertain how the disorder develops and whether it is influenced by the sexual dimorphism in potassium handling. Here, we determine the plasma potassium (PK) threshold for DI in male and female mice and ascertain if the DI is initiated by polydipsia, or a central or nephrogenic defect. C57BL6J mice were randomized to a control diet or to graded reductions in dietary K+ for 8 days, and kidney function and transporters involved in water balance were characterized. We found male and female mice develop polyuria and secondary polydipsia. Altered water balance coincides with a decrease in AQP2 phosphorylation and apical localization despite increased levels of the vasopressin surrogate marker, copeptin. No change in the protein abundance of the urea transporter, UT-A1, was observed. NKCC2 decreased only in males. DDAVP treatment failed to reverse water diuresis in K+-restricted mice. These findings indicate that even small fall in PK is associated with nephrogenic DI (NDI), coincident with the development of altered AQP2 regulation, implicating low PK as a causal trigger of NDI. We found PK decreased more in females, and consequently females were more prone to develop NDI. Together these data indicate that AQP2 regulation is disrupted by a small decrease in PK and the response is influenced by sexual dimorphism in potassium handling. These findings provide new insights into the mechanisms linking water and potassium balances, and support defining the disorder as "Potassium-Dependent NDI."
American Journal of Physiology-Renal Physiology – The American Physiological Society
Published: May 1, 2021
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.