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Bibi Hasnain, A. Mooradian (2004)
Recent trials of antioxidant therapy: what should we be telling our patients?Cleveland Clinic journal of medicine, 71 4
K. Hosohata, H. Ando, A. Fujimura (2012)
Urinary Vanin-1 As a Novel Biomarker for Early Detection of Drug-Induced Acute Kidney InjuryJournal of Pharmacology and Experimental Therapeutics, 341
J. Wedel, P. Jansen, P. Botman, F. Rutjes, J. Schalkwijk, J. Hillebrands (2016)
Pharmacological Inhibition of Vanin Activity Attenuates Transplant Vasculopathy in Rat Aortic AllograftsTransplantation, 100
Carlotta Cavicchio, M. Benedusi, Erika Pambianchi, A. Pecorelli, F. Cervellati, V. Savelli, D. Calamandrei, E. Maellaro, G. Rispoli, E. Maioli, G. Valacchi (2017)
Potassium Ascorbate with Ribose: Promising Therapeutic Approach for Melanoma TreatmentOxidative Medicine and Cellular Longevity, 2017
M Gyurászová, AG Kovalčíková, E Renczés, K Kmeťová, P Celec, J Bábíčková, Ľ Tóthová (2019)
Oxidative stress in animal models of acute and chronic renal failure, 2019
G Bjelakovic, D Nikolova, LL Gluud, RG Simonetti, C Gluud (2008)
Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases, 2
E. Lonn, J. Bosch, S. Yusuf, P. Sheridan, J. Pogue, J. Arnold, C. Ross, A. Arnold, P. Sleight, J. Probstfield, G. Dagenais (2005)
Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial.JAMA, 293 11
N Koumallos, A Sepehripour, I Dimarakis, A Paschalis, A Nasir, N Yonan, I. Laher (2014)
Reactive oxygen species biology and angiotensin regulation of human vascular tone—the role of angiotensin-converting enzyme (ACE) inhibitors and AT1 receptor blockers (ARBs)
T Nitto, K Onodera (2013)
Linkage between coenzyme A metabolism and inflammation: roles of pantetheinase, 123
C. Baigent, R. Lennon (2018)
Should We Increase GFR with Bardoxolone in Alport Syndrome?Journal of the American Society of Nephrology : JASN, 29 2
K. Hosohata (2017)
Biomarkers for Chronic Kidney Disease Associated with High Salt IntakeInternational Journal of Molecular Sciences, 18
Carole Berruyer, L. Pouyet, V. Millet, F. Martin, A. Legoffic, Alexandra Canonici, S. Garcia, C. Bagnis, P. Naquet, F. Galland (2006)
Vanin-1 licenses inflammatory mediator production by gut epithelial cells and controls colitis by antagonizing peroxisome proliferator-activated receptor γ activityThe Journal of Experimental Medicine, 203
L. Ling, Hai-tao Lu, Hai-feng Wang, Mei-jia Shen, Hong-bo Zhang (2019)
MicroRNA-203 Acts as a Potent Suppressor in Septic Shock by Alleviating Lung Injury via Inhibition of VNN1Kidney and Blood Pressure Research, 44
S. Washino, K. Hosohata, D. Jin, S. Takai, T. Miyagawa (2018)
Early urinary biomarkers of renal tubular damage by a high‐salt intake independent of blood pressure in normotensive ratsClinical and Experimental Pharmacology and Physiology, 45
Adrian Davies, Alan Holt (2018)
Why antioxidant therapies have failed in clinical trials.Journal of theoretical biology, 457
Thomas Gensollen, C. Bourges, P. Rihet, Agathe Rostan, V. Millet, T. Noguchi, V. Bourdon, H. Sobol, L. Dubuquoy, B. Bertin, M. Fumery, P. Desreumaux, J. Colombel, X. Hébuterne, P. Hofman, P. Naquet, F. Galland (2013)
Functional Polymorphisms in the Regulatory Regions of the VNN1 Gene Are Associated with Susceptibility to Inflammatory Bowel DiseasesInflammatory Bowel Diseases, 19
Bing Zhang, C. Lo, Lei Shen, R. Sood, Carol Jones, K. Cusmano-Ozog, S. Park-Snyder, W. Wong, M. Jeng, T. Cowan, E. Engleman, J. Zehnder (2011)
The role of vanin-1 and oxidative stress-related pathways in distinguishing acute and chronic pediatric ITP.Blood, 117 17
F. Leth, Db Hall, J. Lange, P. Reiss (2006)
Plasma lipid concentrations after 1.5 years of exposure to nevirapine or efavirenz together with stavudine and lamivudineHIV Medicine, 7
J. Kanabus-Kaminska, M. Feeley, H. Birnboim (1988)
Simultaneous protective and damaging effects of cysteamine on intracellular DNA of leukocytes.Free radical biology & medicine, 4 3
B. Ruan, D. Cole, Paul Wu, A. Quazi, K. Page, Jill Wright, N. Huang, J. Stock, K. Nocka, A. Aulabaugh, R. Krykbaev, L. Fitz, N. Wolfman, M. Fleming (2010)
A fluorescent assay suitable for inhibitor screening and vanin tissue quantification.Analytical biochemistry, 399 2
Tim Fugmann, B. Borgia, C. Révész, M. Godó, C. Forsblom, P. Hamar, H. Holthöfer, D. Neri, C. Roesli (2011)
Proteomic identification of vanin-1 as a marker of kidney damage in a rat model of type 1 diabetic nephropathy.Kidney international, 80 3
P. Jansen, J. Diepen, B. Ritzen, P. Zeeuwen, I. Cacciatore, C. Cornacchia, I. Vlijmen-Willems, Erik Heuvel, P. Botman, R. Blaauw, P. Hermkens, F. Rutjes, J. Schalkwijk (2013)
Discovery of small molecule vanin inhibitors: new tools to study metabolism and disease.ACS chemical biology, 8 3
H. Selye, S. Szabó (1973)
Experimental Model for Production of Perforating Duodenal Ulcers by Cysteamine in the RatNature, 244
SK Myung, W Ju, B Cho, SW Oh, SM Park, BK Koo, BJ Park (2013)
Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials, 346
A Duni, V Liakopoulos, S Roumeliotis, D Peschos, E Dounousi (2019)
Oxidative stress in the pathogenesis and evolution of chronic kidney disease: untangling Ariadne’s thread, 20
Siyu Chen, Wenxiang Zhang, C-W Tang, Xiaoli Tang, Li Liu, Chang Liu (2014)
Vanin-1 Is a Key Activator for Hepatic GluconeogenesisDiabetes, 63
BL Coelho, LG Rocha, KS Scarabelot, DL Scheffer, MM Ronsani, PC Silveira, LA Silva, CT Souza, RA Pinho (2010)
Physical exercise prevents the exacerbation of oxidative stress parameters in chronic kidney disease, 20
M. Sagoo, L. Gnudi (2018)
Diabetic nephropathy: Is there a role for oxidative stress?Free radical biology & medicine, 116
H. Kang, S. Ahn, Peter Choi, Y. Ko, S. Han, Frank Chinga, Ae Park, Jianling Tao, K. Sharma, J. Pullman, E. Bottinger, I. Goldberg, K. Suszták (2014)
Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis developmentNature Medicine, 21
D. Socci, K. Bjugstad, H. Jones, J. Pattisapu, G. Arendash (1999)
Evidence That Oxidative Stress Is Associated with the Pathophysiology of Inherited Hydrocephalus in the H-Tx Rat ModelExperimental Neurology, 155
Marije Velde, K. Matsushita, J. Coresh, B. Astor, M. Woodward, A. Levey, P. Jong, R. Gansevoort, Marije Velde, A. Levey, P. Jong, M. El-Nahas, K. Eckardt, B. Kasiske, T. Ninomiya, J. Chalmers, S. MacMahon, M. Tonelli, B. Hemmelgarn, F. Sacks, G. Curhan, A. Collins, Suying Li, Shu‐Cheng Chen, K. Cohort, Brian Lee, A. Ishani, J. Neaton, K. Svendsen, J. Mann, S. Yusuf, K. Teo, P. Gao, R. Nelson, W. Knowler, H. Bilo, H. Joosten, N. Kleefstra, K. Groenier, P. Auguste, Kasper Veldhuis, Yaping Wang, Laura Camarata, B. Thomas, Tom Manley (2011)
Lower estimated glomerular filtration rate and higher albuminuria are associated with all-cause and cardiovascular mortality. A collaborative meta-analysis of high-risk population cohorts.Kidney international, 79 12
B. Kaskow, J. Proffit, J. Blangero, E. Moses, E. Moses, L. Abraham (2012)
Diverse biological activities of the vascular non-inflammatory molecules - the Vanin pantetheinases.Biochemical and biophysical research communications, 417 2
R Marchioli, G Levantesi, A Macchia, RM Marfisi, GL Nicolosi, L Tavazzi, G Tognoni, F Valagussa (2006)
Vitamin E increases the risk of developing heart failure after myocardial infarction: results from the GISSI-Prevenzione trial, 7
F Martin, MF Penet, F Malergue, H Lepidi, A Dessein, F Galland, M de Reggi, P Naquet, B Gharib (2004)
Vanin-1–/– mice show decreased NSAID- and Schistosoma-induced intestinal inflammation associated with higher glutathione stores, 113
F. Sánchez-Muñoz, L. Amezcua-Guerra, M. Macías-Palacios, R. Márquez-Velasco, R. Bojalil (2013)
Vanin-1 as a potential novel biomarker for active nephritis in systemic lupus erythematosusLupus, 22
M. Coughlan, K. Sharma (2016)
Challenging the dogma of mitochondrial reactive oxygen species overproduction in diabetic kidney disease.Kidney international, 90 2
K. Hosohata, H. Ando, Y. Fujiwara, A. Fujimura (2011)
Vanin-1: a potential biomarker for nephrotoxicant-induced renal injury.Toxicology, 290 1
G. Pitari, F. Malergue, F. Martin, J. Philippe, Maria Massucci, C. Chabret, B. Maras, S. Dupré, P. Naquet, F. Galland (2000)
Pantetheinase activity of membrane‐bound Vanin‐1: lack of free cysteamine in tissues of Vanin‐1 deficient miceFEBS Letters, 483
L Pouyet, C Roisin-Bouffay, A Clément, V Millet, S Garcia, L Chasson, N Issaly, A Rostan, P Hofman, P Naquet, F Galland (2010)
Epithelial vanin-1 controls inflammation-driven carcinogenesis in the colitis-associated colon cancer model, 16
Carole Berruyer, F. Martin, R. Castellano, A. Macone, F. Malergue, S. Garrido‐Urbani, V. Millet, J. Imbert, S. Duprè, G. Pitari, P. Naquet, F. Galland (2004)
Vanin-1−/− Mice Exhibit a Glutathione-Mediated Tissue Resistance to Oxidative StressMolecular and Cellular Biology, 24
Daryl Okamura, Nadia Bahrami, S. Ren, Katie Pasichnyk, J. Williams, J. Gangoiti, J. López-Guisa, Ikuyo Yamaguchi, B. Barshop, J. Duffield, A. Eddy (2014)
Cysteamine modulates oxidative stress and blocks myofibroblast activity in CKD.Journal of the American Society of Nephrology : JASN, 25 1
K. Singbartl, J. Kellum (2012)
AKI in the ICU: definition, epidemiology, risk stratification, and outcomes.Kidney international, 81 9
JK Liao, U Laufs (2005)
Pleiotropic effects of statins, 45
F. Galland, F. Malergue, H. Bazin, M. Mattei, M. Aurrand-Lions, C. Theillet, P. Naquet (1998)
Two human genes related to murine vanin-1 are located on the long arm of human chromosome 6.Genomics, 53 2
Takumi Yoshida, M. Kurella, F. Beato, Hyunsuk Min, J. Ingelfinger, R. Stears, R. Swinford, S. Gullans, S. Tang (2002)
Monitoring changes in gene expression in renal ischemia-reperfusion in the rat.Kidney international, 61 5
Kengo Yamawaki, H. Kanda, R. Shimazaki (2018)
Nrf2 activator for the treatment of kidney diseasesToxicology and Applied Pharmacology, 360
P Pavlakou, V Liakopoulos, T Eleftheriadis, M Mitsis, E Dounousi (2017)
Oxidative stress and acute kidney injury in critical illness: pathophysiologic mechanisms—biomarkers—interventions, and future perspectives, 2017
Oxidative stress is a key concept in basic, translational and clinical research to understand the pathophysiology of various disorders, including cardiovascular and renal diseases. While attempts to directly reduce oxidative stress with redox-active substances have until now largely failed to prove clinical benefit, indirect approaches to combat oxidative stress enzymatically gain further attention as potential therapeutic strategies. The pantetheinase Vanin-1 is expressed on kidney proximal tubular cells and its reaction product cysteamine is described to negatively affect redox homeostasis by inhibiting the replenishment of cellular anti-oxidative glutathione stores. Vanin-1 deficient mice were shown to be protected against various oxidative stress damages. The aim of this study was to elucidate whether pharmacological inhibition of Vanin-1 protects mice from oxidative stress related acute or chronic kidney injury as well. By studying renal ischemia reperfusion injury and Col4α3-/- (Alport syndrome) mice and in vitro hypoxia/reoxygenation on human proximal tubular cells we found that treatment with a selective and potent Vanin‑1 inhibitor resulted in ample inhibition of enzymatic activity in vitro and in vivo. However, surrogate parameters of metabolic and redox homeostasis were only partially and insufficiently affected. Consequently, apoptosis and reactive oxygen species level in tubular cells as well as overall kidney function and fibrotic processes were not improved by Vanin-1 inhibition. We thus conclude that Vanin-1 functionality in the context of cardiovascular diseases needs further investigations and the biological relevance of pharmacological Vanin-1 inhibition for the treatment of kidney diseases remains to be proven.
American Journal of Physiology-Renal Physiology – The American Physiological Society
Published: Jan 1, 2021
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