Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Pathogenesis of obstructive sleep apnea in people living with HIV

Pathogenesis of obstructive sleep apnea in people living with HIV Obstructive sleep apnea (OSA) is highly prevalent in people living with HIV (PLWH), and might contribute to frequently reported symptoms and co-morbidities. Traditional risk factors for OSA are often absent in PLWH, suggesting that HIV or HIV medications might predispose to OSA. Therefore, we measured the anatomical and non-anatomical traits important for OSA pathogenesis in those with and without HIV. We recruited virally-suppressed PLWH who had been previously diagnosed with OSA (PLWH+OSA) adherent to positive airway pressure (PAP) therapy, along with age, gender and body mass index (BMI) matched OSA controls. All participants underwent a baseline polysomnogram to assess OSA severity, and a second overnight research sleep study during which the airway pressure was adjusted slowly or rapidly to measure the OSA traits. Seventeen PLWH+OSA and 17 OSA control participants were studied (median age 58 IQR[54, 65] years, BMI 30.7 [28.4, 31,8] kg/m2, apnea-hypopnea index 46 [24, 74]/h. The groups were similar, although PLWH+OSA demonstrated greater sleepiness (despite PAP) and worse sleep efficiency on baseline polysomnography. On physiological testing during sleep, there were no statistically significant differences in OSA traits (including Veupnea, Varousal, Vpassive, Vactive, and loop gain) between PLWH+OSA and OSA controls, using mixed-effects modeling to account for age, gender, and BMI, and incorporating each repeated measurement (range 72-334 measures/trait). Our data suggest that well treated HIV does not substantially impact the pathogenesis of OSA. Given similar underlying physiology, existing available therapeutic approaches are likely to be adequate to manage OSA in PLWH, which might improve symptoms and co-morbidities. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Applied Physiology The American Physiological Society

Pathogenesis of obstructive sleep apnea in people living with HIV

Download PDF
8 pages

Loading next page...
 
/lp/the-american-physiological-society/pathogenesis-of-obstructive-sleep-apnea-in-people-living-with-hiv-NyoorBPGty

References (36)

ISSN
8750-7587
eISSN
1522-1601
DOI
10.1152/japplphysiol.00591.2021
Publisher site
See Article on Publisher Site

Abstract

Obstructive sleep apnea (OSA) is highly prevalent in people living with HIV (PLWH), and might contribute to frequently reported symptoms and co-morbidities. Traditional risk factors for OSA are often absent in PLWH, suggesting that HIV or HIV medications might predispose to OSA. Therefore, we measured the anatomical and non-anatomical traits important for OSA pathogenesis in those with and without HIV. We recruited virally-suppressed PLWH who had been previously diagnosed with OSA (PLWH+OSA) adherent to positive airway pressure (PAP) therapy, along with age, gender and body mass index (BMI) matched OSA controls. All participants underwent a baseline polysomnogram to assess OSA severity, and a second overnight research sleep study during which the airway pressure was adjusted slowly or rapidly to measure the OSA traits. Seventeen PLWH+OSA and 17 OSA control participants were studied (median age 58 IQR[54, 65] years, BMI 30.7 [28.4, 31,8] kg/m2, apnea-hypopnea index 46 [24, 74]/h. The groups were similar, although PLWH+OSA demonstrated greater sleepiness (despite PAP) and worse sleep efficiency on baseline polysomnography. On physiological testing during sleep, there were no statistically significant differences in OSA traits (including Veupnea, Varousal, Vpassive, Vactive, and loop gain) between PLWH+OSA and OSA controls, using mixed-effects modeling to account for age, gender, and BMI, and incorporating each repeated measurement (range 72-334 measures/trait). Our data suggest that well treated HIV does not substantially impact the pathogenesis of OSA. Given similar underlying physiology, existing available therapeutic approaches are likely to be adequate to manage OSA in PLWH, which might improve symptoms and co-morbidities.

Journal

Journal of Applied Physiology – The American Physiological Society

Published: Dec 1, 2021

There are no references for this article.