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References (60)
-
Yuanyuan Jiang, G. Lu, Laura Trescott, Yuning Hou, X. Guan, Shuo Wang, Angelique Stamenkovich, J. Brunzelle, N. Sirinupong, Chunying Li, Zhe Yang (2013)
New Conformational State of NHERF1-CXCR2 Signaling Complex Captured by Crystal Lattice TrappingPLoS ONE, 8
-
Licui Sun, Junfang Zheng, Qiqi Wang, Ran Song, Hua Liu, R. Meng, T. Tao, Y. Si, Wenguo Jiang, Junqi He (2016)
NHERF1 regulates actin cytoskeleton organization through modulation of α‐actinin‐4 stabilityThe FASEB Journal, 30
-
KL Leslie, GJ Song, S Barrick, VL Wehbi, JP Vilardaga, PM Bauer, A Bisello (2013)
Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) and nuclear factor-κB (NF-κB): a feed-forward loop for systemic and vascular inflammation, 288
-
Damien Garbett, D. Lalonde, A. Bretscher (2010)
The scaffolding protein EBP50 regulates microvillar assembly in a phosphorylation-dependent mannerThe Journal of Cell Biology, 191
-
C. Scala, C. Baier, Luke Evans, P. Williamson, J. Fantini, F. Barrantes (2017)
Relevance of CARC and CRAC Cholesterol-Recognition Motifs in the Nicotinic Acetylcholine Receptor and Other Membrane-Bound Receptors.Current topics in membranes, 80
-
Man Li, A. Mennone, C. Soroka, L. Hagey, Xinshou Ouyang, E. Weinman, J. Boyer (2015)
Na+/H+ exchanger regulatory factor 1 knockout mice have an attenuated hepatic inflammatory response and are protected from cholestatic liver injuryHepatology, 62
-
E. Weinman, D. Steplock, D. Corry, S. Shenolikar (1993)
Identification of the human NHE-1 form of Na(+)-H+ exchanger in rabbit renal brush border membranes.The Journal of clinical investigation, 91 5
-
I. Ghouleh, Daniel Meijles, Stephanie Mutchler, Qiangmin Zhang, S. Sahoo, A. Gorelova, J. Amaral, Andres Rodriguez, Tatyana Mamonova, G. Song, G. Song, A. Bisello, P. Friedman, M. Cifuentes-Pagano, P. Pagano (2016)
Binding of EBP50 to Nox organizing subunit p47phox is pivotal to cellular reactive species generation and altered vascular phenotypeProceedings of the National Academy of Sciences, 113
-
A. Malfettone, N. Silvestris, A. Paradiso, E. Mattioli, G. Simone, A. Mangia (2012)
Overexpression of nuclear NHERF1 in advanced colorectal cancer: association with hypoxic microenvironment and tumor invasive phenotype.Experimental and molecular pathology, 92 3
-
J. Song, J. Bai, W. Yang, E. Gabrielson, D. Chan, Z. Zhang (2007)
Expression and clinicopathological significance of oestrogen‐responsive ezrin–radixin–moesin‐binding phosphoprotein 50 in breast cancerHistopathology, 51
-
Jing Sun, Peng Li, Jian Yang (2019)
Repressing of NHERF1 inhibits liver cancer progression by promoting the production of ROS.Biochemical and biophysical research communications, 509 1
-
Thanh Ho-Bouldoires, A. Clapéron, M. Mergey, D. Wendum, C. Desbois-Mouthon, S. Tahraoui, L. Fartoux, Hamza Chettouh, Fatiha Merabtene, O. Scatton, M. Gaestel, F. Praz, C. Housset, L. Fouassier (2015)
Mitogen-activated protein kinase-activated protein kinase 2 mediates resistance to hydrogen peroxide-induced oxidative stress in human hepatobiliary cancer cells.Free radical biology & medicine, 89
-
Mengyao Ji, D. Fan, Xiao-guang Lv, Xiulan Peng, Xiao-fei Lei, W. Dong (2012)
The detection of EBP50 expression using quantum dot immunohistochemistry in pancreatic cancer tissue and down-regulated EBP50 effect on PC-2 cellsJournal of Molecular Histology, 43
-
Kristen Leslie, G. Song, S. Barrick, Vanessa Wehbi, J. Vilardaga, P. Bauer, A. Bisello (2013)
Ezrin-Radixin-Moesin-binding Phosphoprotein 50 (EBP50) and Nuclear Factor-κB (NF-κB)The Journal of Biological Chemistry, 288
-
A. Mangia, L. Caldarola, S. Dell'endice, E. Scarpi, L. Saragoni, M. Monti, D. Santini, O. Brunetti, G. Simone, N. Silvestris (2015)
The potential predictive role of nuclear NHERF1 expression in advanced gastric cancer patients treated with epirubicin/oxaliplatin/capecitabine first line chemotherapyCancer Biology & Therapy, 16
-
T. Karn, E. Ruckhäberle, L. Hanker, V. Müller, Marcus Schmidt, C. Solbach, R. Gätje, M. Gehrmann, U. Holtrich, M. Kaufmann, A. Rody (2011)
Gene expression profiling of luminal B breast cancers reveals NHERF1 as a new marker of endocrine resistanceBreast Cancer Research and Treatment, 130
-
Xianying Fang, R. Song, Wei Chen, Yuanyuan Yang, Yanhong Gu, Y. Shu, Xuefeng Wu, Xuefeng Wu, Yang Sun, Yan Shen, Qiang Xu (2015)
PRL-3 Promotes the Malignant Progression of Melanoma via Triggering Dephosphorylation and Cytoplasmic Localization of NHERF1.The Journal of investigative dermatology, 135 9
-
R. Cardone, A. Bellizzi, Giovanni Busco, E. Weinman, M. Dell’Aquila, V. Casavola, A. Azzariti, A. Mangia, A. Paradiso, S. Reshkin (2007)
The NHERF1 PDZ2 domain regulates PKA-RhoA-p38-mediated NHE1 activation and invasion in breast tumor cells.Molecular biology of the cell, 18 5
-
M. Greco, Émeline Bon, R. Rubino, L. Guerra, Manuel Bernabé-García, Stefania Cannone, M. Cayuela, Loredana Ciaccia, S. Marionneau-Lambot, T. Oullier, G. Fromont, Roseline Guibon, S. Roger, S. Reshkin, R. Cardone (2019)
Phosphorylation of NHERF1 S279 and S301 differentially regulates breast cancer cell phenotype and metastatic organotropism.Biochimica et biophysica acta. Molecular basis of disease, 1865 1
-
J. Jeong, Wonnam Kim, J. Hens, P. Dann, P. Schedin, P. Friedman, J. Wysolmerski (2019)
NHERF1 is Required for Localization of PMCA2 and Suppression of Early Involution in the Female Lactating Mammary Gland.Endocrinology
-
G. Antalffy, A. Caride, K. Pászty, L. Hegedűs, Rita Padányi, E. Strehler, Á. Enyedi (2011)
Apical localization of PMCA2w/b is enhanced in terminally polarized MDCK cells.Biochemical and biophysical research communications, 410 2
-
J. Molina, F. Morales, Y. Hayashi, K. Aldape, M. Georgescu (2010)
Loss of PTEN binding adapter protein NHERF1 from plasma membrane in glioblastoma contributes to PTEN inactivation.Cancer research, 70 17
-
C. Ketchem, S. Khundmiri, A. Gaweda, Rebecca Murray, B. Clark, E. Weinman, E. Lederer (2015)
Role of Na+/H+ exchanger regulatory factor 1 in forward trafficking of the type IIa Na+-Pi cotransporter.American journal of physiology. Renal physiology, 309 2
-
C. Saponaro, Sara Sergio, Antonio Coluccia, M. Luca, G. Regina, L. Mologni, Valeria Famiglini, Valentina Naccarato, Daniela Bonetti, Candice Gautier, S. Gianni, D. Vergara, M. Salzet, I. Fournier, C. Bucci, R. Silvestri, C. Passerini, M. Maffia, A. Coluccia (2018)
β-catenin knockdown promotes NHERF1-mediated survival of colorectal cancer cells: implications for a double-targeted therapyOncogene, 37
-
A. Malfettone, C. Saponaro, A. Paradiso, G. Simone, A. Mangia (2012)
Peritumoral vascular invasion and NHERF1 expression define an immunophenotype of grade 2 invasive breast cancer associated with poor prognosisBMC Cancer, 12
-
J. Molina, N. Agarwal, F. Morales, Y. Hayashi, K. Aldape, Gilbert Cote, M. Georgescu (2011)
PTEN, NHERF1 and PHLPP form a tumor suppressor network that is disabled in glioblastomaOncogene, 31
-
J. Dai, Lei Wang, A. Sahin, L. Broemeling, M. Schutte, Yong Pan (2004)
NHERF (Na+/H+ Exchanger Regulatory Factor) gene mutations in human breast cancerOncogene, 23
-
Z. Karim, B. Gérard, N. Bakouh, R. Alili, C. Leroy, L. Beck, C. Silve, G. Planelles, P. Ureña-Torres, B. Grandchamp, G. Friedlander, D. Prié (2008)
NHERF1 mutations and responsiveness of renal parathyroid hormone.The New England journal of medicine, 359 11
-
Guifang Du, Chengcheng Hao, Yanan Gu, Zhiyan Wang, W. Jiang, Junqi He, Shan Cheng (2016)
A Novel NHERF1 Mutation in Human Breast Cancer Inactivates Inhibition by NHERF1 Protein in EGFR Signaling.Anticancer research, 36 3
-
A. Bellizzi, A. Mangia, A. Malfettone, R. Cardone, G. Simone, S. Reshkin, A. Paradiso (2011)
Na+/H+ exchanger regulatory factor 1 expression levels in blood and tissue predict breast tumour clinical behaviourHistopathology, 58
-
L. Fouassier, Cheng-yin Duan, A. Feranchak, C. Yun, E. Sutherland, F. Simon, J. Fitz, R. Doctor (2001)
Ezrin‐radixin‐moesin–binding phosphoprotein 50 is expressed at the apical membrane of rat liver epitheliaHepatology, 33
-
A. Bushau-Sprinkle, M. Barati, Caryl Conklin, T. Dupre, K. Gagnon, S. Khundmiri, Barbara Clark, Leah Siskind, M. Doll, M. Rane, M. Brier, S. Coventry, E. Lederer (2019)
Loss of the Na+/H+ Exchange Regulatory Factor 1 Increases Susceptibility to Cisplatin-Induced Acute Kidney Injury.The American journal of pathology, 189 6
-
Jianqing Wang, Fu Qin, Liang Zhu (2015)
Expression of Na+/H+ exchanger regulatory factor 1 in autosomal-dominant polycystic kidney diseaseJournal of International Medical Research, 43
-
T. Bartholow, M. Becich, U. Chandran, A. Parwani (2011)
Immunohistochemical analysis of ezrin-radixin-moesin-binding phosphoprotein 50 in prostatic adenocarcinomaBMC Urology, 11
-
Lei Wang, Y. Qi, Ying Xiong, Zhiqiang Peng, Q. Ma, Yue Zhang, Jian Song, Junfang Zheng (2017)
Ezrin-Radixin-Moesin Binding Phosphoprotein 50 (EBP50) Suppresses the Metastasis of Breast Cancer and HeLa Cells by Inhibiting Matrix Metalloproteinase-2 Activity.Anticancer research, 37 8
-
M. Barati, C. Ketchem, M. Merchant, Walter Kusiak, P. Jose, E. Weinman, A. LeBlanc, E. Lederer, S. Khundmiri (2017)
Loss of NHERF-1 expression prevents dopamine-mediated Na-K-ATPase regulation in renal proximal tubule cells from rat models of hypertension: aged F344 rats and spontaneously hypertensive rats.American journal of physiology. Cell physiology, 313 2
-
Bruce Sneddon, Giovanni Ruiz, Luciana Gallo, K. Xiao, Qiangmin Zhang, Y. Rbaibi, O. Weisz, G. Apodaca, P. Friedman (2016)
Convergent Signaling Pathways Regulate Parathyroid Hormone and Fibroblast Growth Factor-23 Action on NPT2A-mediated Phosphate Transport*The Journal of Biological Chemistry, 291
-
M. Georgescu, Paul Yell, B. Mobley, Ping Shang, T. Georgescu, Shih-Hsiu Wang, P. Canoll, K. Hatanpaa, C. III, J. Raisanen (2015)
NHERF1/EBP50 is an organizer of polarity structures and a diagnostic marker in ependymomaActa Neuropathologica Communications, 3
-
M. Georgescu, F. Morales, J. Molina, Y. Hayashi (2008)
Roles of NHERF1/EBP50 in cancer.Current molecular medicine, 8 6
-
R. Accardi, R. Rubino, M. Scalise, T. Gheit, Naveed Shahzad, Miranda Thomas, L. Banks, C. Indiveri, B. Sylla, R. Cardone, S. Reshkin, M. Tommasino (2011)
E6 and E7 from Human Papillomavirus Type 16 Cooperate To Target the PDZ Protein Na/H Exchange Regulatory Factor 1Journal of Virology, 85
-
Feng-lian Yang, Yanan Gu, Zehang Zhao, Jing Huang, W. Jiang, Shan Cheng (2017)
NHERF1 Suppresses Lung Cancer Cell Migration by Regulation of Epithelial-Mesenchymal Transition.Anticancer research, 37 8
-
T. Shibata, M. Chuma, A. Kokubu, M. Sakamoto, S. Hirohashi (2003)
EBP50, a β‐catenin–associating protein, enhances Wnt signaling and is over‐expressed in hepatocellular carcinomaHepatology, 38
-
A. Mangia, Giulia Partipilo, L. Schirosi, C. Saponaro, D. Galetta, A. Catino, A. Scattone, G. Simone (2015)
Fine Needle Aspiration Cytology: A Tool to Study NHERF1 Expression as a Potential Marker of Aggressiveness in Lung CancerMolecular Biotechnology, 57
-
A. Tabrizi, S. Kalloger, M. Köbel, Jane Cipollone, C. Roskelley, Erika Mehl, Blake Gilks (2010)
Primary Ovarian Mucinous Carcinoma of Intestinal Type: Significance of Pattern of Invasion and Immunohistochemical Expression Profile in a Series of 31 CasesInternational Journal of Gynecological Pathology, 29
-
A. Mangia, A. Chiriatti, A. Bellizzi, A. Malfettone, B. Stea, Francesso Zito, Stephen Reshkin, G. Simone, A. Paradiso (2009)
Biological role of NHERF1 protein expression in breast cancerHistopathology, 55
-
E. Weinman, E. Lederer (2012)
NHERF-1 and the regulation of renal phosphate reabsoption: a tale of three hormones.American journal of physiology. Renal physiology, 303 3
-
M. Katoh (2018)
Multi-layered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/β-catenin signaling activation (Review)International Journal of Molecular Medicine, 42
-
S. Shenolikar, James Voltz, C. Minkoff, J. Wade, E. Weinman (2002)
Targeted disruption of the mouse NHERF-1 gene promotes internalization of proximal tubule sodium-phosphate cotransporter type IIa and renal phosphate wastingProceedings of the National Academy of Sciences of the United States of America, 99
-
M. Favia, L. Guerra, T. Fanelli, R. Cardone, S. Monterisi, F. Sole, S. Castellani, Mingmin Chen, U. Seidler, S. Reshkin, M. Conese, V. Casavola (2010)
Na+/H+ Exchanger Regulatory Factor 1 Overexpression-dependent Increase of Cytoskeleton Organization Is Fundamental in the Rescue of F508del Cystic Fibrosis Transmembrane Conductance Regulator in Human Airway CFBE41o- CellsMolecular Biology of the Cell, 21
-
R. Cardone, M. Greco, M. Capulli, E. Weinman, Giovanni Busco, A. Bellizzi, V. Casavola, Ester Antelmi, B. Ambruosi, M. Dell’Aquila, A. Paradiso, A. Teti, N. Rucci, S. Reshkin (2012)
NHERF1 acts as a molecular switch to program metastatic behavior and organotropism via its PDZ domainsMolecular Biology of the Cell, 23
-
L. Wang, Yucong Du, M. Ji, W. Wang, N. Zhan, Q-S Zhou, W.-G. Dong (2014)
Reduced EBP50 expression or mis-localization of the EBP50 protein is associated with the malignant progression of esophageal squamous cell carcinoma.European review for medical and pharmacological sciences, 18 24
-
E. Kreimann, M. Ratajska, Alina Kuźniacka, Brenda Demacopulo, M. Stukan, J. Limon (2015)
A novel splicing mutation in the SLC9A3R1 gene in tumors from ovarian cancer patients.Oncology letters, 10 6
-
David Bryant, Julie Roignot, A. Datta, Arend Overeem, Minji Kim, Wei Yu, Xiao Peng, D. Eastburn, A. Ewald, Z. Werb, K. Mostov (2014)
A molecular switch for the orientation of epithelial cell polarization.Developmental cell, 31 2
-
Hong Cheng, Jianquan Li, R. Fazlieva, Zhongping Dai, Z. Bu, H. Roder (2009)
Autoinhibitory interactions between the PDZ2 and C-terminal domains in the scaffolding protein NHERF1.Structure, 17 5
-
K. Kislin, Wendy McDonough, J. Eschbacher, B. Armstrong, M. Berens (2009)
NHERF-1: modulator of glioblastoma cell migration and invasion.Neoplasia, 11 4
-
S. Schmieder, Masaaki Nagai, R. Orlando, T. Takeda, M. Farquhar (2004)
Podocalyxin activates RhoA and induces actin reorganization through NHERF1 and Ezrin in MDCK cells.Journal of the American Society of Nephrology : JASN, 15 9
-
Javier Vaquero, T. Ho-Bouldoires, A. Clapéron, L. Fouassier (2017)
Role of the PDZ-scaffold protein NHERF1/EBP50 in cancer biology: from signaling regulation to clinical relevanceOncogene, 36
-
L. Schirosi, A. Mazzotta, G. Opinto, R. Pinto, G. Graziano, S. Tommasi, L. Fucci, G. Simone, A. Mangia (2016)
β-catenin interaction with NHERF1 and RASSF1A methylation in metastatic colorectal cancer patientsOncotarget, 7
-
C. Saponaro, A. Vagheggini, E. Scarpi, Matteo Centonze, I. Catacchio, Ondina Popescu, M. Pastena, F. Giotta, N. Silvestris, A. Mangia (2018)
NHERF1 and tumor microenvironment: a new scene in invasive breast carcinomaJournal of Experimental & Clinical Cancer Research : CR, 37
-
S. Khundmiri, E. Weinman, D. Steplock, J. Cole, Aamir Ahmad, Patrick Baumann, M. Barati, M. Rane, E. Lederer (2005)
Parathyroid hormone regulation of NA+,K+-ATPase requires the PDZ 1 domain of sodium hydrogen exchanger regulatory factor-1 in opossum kidney cells.Journal of the American Society of Nephrology : JASN, 16 9
- ISSN
- 1931-857x
- eISSN
- 1522-1466
- DOI
- 10.1152/ajprenal.00467.2019
- Publisher site
- See Article on Publisher Site
Abstract
Na+/H+ exchange regulatory factor 1 (NHERF1), a member of a PDZ scaffolding protein family, was first identified as an organizer of membrane-bound protein complexes composed of hormone receptors, signal transduction pathways, and electrolyte and mineral transporters and channels. NHERF1 is involved in the regulation of Na+/H+ exchanger 3, Na+-dependent phosphate transporter 2a, and Na+-K+-ATPase through its ability to scaffold these transporters to the plasma membrane, allowing regulation of these protein complexes with their associated hormone receptors. Recently, NHERF1 has received increased interest in its involvement in a variety of functions, including cell structure and trafficking, tumorigenesis and tumor behavior, inflammatory responses, and tissue injury. In this review, we highlight the evidence for the expansive role of NHERF1 in cell biology and speculate on the implications for renal physiology and pathophysiology.
Journal
American Journal of Physiology-Renal Physiology – The American Physiological Society
Published: Mar 1, 2020