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Mike Mueckler (1953–2021): the father of the mammalian SLC2 glucose transporter family

Mike Mueckler (1953–2021): the father of the mammalian SLC2 glucose transporter family Am J Physiol Endocrinol Metab 321: E490–E492, 2021. First published August 23, 2021; doi:10.1152/ajpendo.00290.2021 EDITORIAL Mike Mueckler (1953–2021): the father of the mammalian SLC2 glucose transporter family 1 2 David E. James and Bernard Thorens Charles Perkins Centre, School of Life and Environmental Sciences and School of Medical Sciences, The University of Sydney, Camperdown, New South Wales, Australia and Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland Mike Mueckler pioneered the molecular analysis of mamma- the human erythrocyte glucose transporter and had lian facilitative glucose transport, one of the most funda- approached Lodish about the possibility of using the antibody mental biological processes of cellular energy homeostasis. to clone the glucose transporter, something that had never He was the first person to describe the molecular cloning of been done before. Mike took this on as his postdoctoral pro- mammalian facilitative glucose transporter in 1985. This ject using the cavalier approach of expression cloning using study paved the way for an entire field of pursuit that contin- Gus’ antibody to screen a cDNA library derived from HepG2 ues to this day and for which Mike is largely credited. Mike cells that they knew had http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Endocrinology and Metabolism The American Physiological Society

Mike Mueckler (1953–2021): the father of the mammalian SLC2 glucose transporter family

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ISSN
0193-1849
eISSN
1522-1555
DOI
10.1152/ajpendo.00290.2021
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Abstract

Am J Physiol Endocrinol Metab 321: E490–E492, 2021. First published August 23, 2021; doi:10.1152/ajpendo.00290.2021 EDITORIAL Mike Mueckler (1953–2021): the father of the mammalian SLC2 glucose transporter family 1 2 David E. James and Bernard Thorens Charles Perkins Centre, School of Life and Environmental Sciences and School of Medical Sciences, The University of Sydney, Camperdown, New South Wales, Australia and Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland Mike Mueckler pioneered the molecular analysis of mamma- the human erythrocyte glucose transporter and had lian facilitative glucose transport, one of the most funda- approached Lodish about the possibility of using the antibody mental biological processes of cellular energy homeostasis. to clone the glucose transporter, something that had never He was the first person to describe the molecular cloning of been done before. Mike took this on as his postdoctoral pro- mammalian facilitative glucose transporter in 1985. This ject using the cavalier approach of expression cloning using study paved the way for an entire field of pursuit that contin- Gus’ antibody to screen a cDNA library derived from HepG2 ues to this day and for which Mike is largely credited. Mike cells that they knew had

Journal

AJP - Endocrinology and Metabolism – The American Physiological Society

Published: Oct 1, 2021

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