Access the full text.
Sign up today, get DeepDyve free for 14 days.
Vikram Sundararaghavan, P. Sindhwani, T. Hinds (2016)
Glucuronidation and UGT isozymes in bladder: new targets for the treatment of uroepithelial carcinomas?Oncotarget, 8
Chunling Li, Yu Lin, R. Luo, Shaoming Chen, Feifei Wang, P. Zheng, M. Levi, Tianxin Yang, Weidong Wang (2016)
Intrarenal renin-angiotensin system mediates fatty acid-induced ER stress in the kidney.American journal of physiology. Renal physiology, 310 5
D. Jump, D. Botolin, Yun Wang, Jinghua Xu, Barbara Christian, O. Demeure (2005)
Fatty acid regulation of hepatic gene transcription.The Journal of nutrition, 135 11
T. Hinds, P. Hosick, Shujuan Chen, R. Tukey, Michael Hankins, A. Nestor-Kalinoski, D. Stec (2017)
Mice with hyperbilirubinemia due to Gilbert's syndrome polymorphism are resistant to hepatic steatosis by decreased serine 73 phosphorylation of PPARα.American journal of physiology. Endocrinology and metabolism, 312 4
Yu Lin, P. Chang, Fu-Chang Hu, Mei‐Hwei Chang, Y. Ni (2009)
Variants in the UGT1A1 Gene and the Risk of Pediatric Nonalcoholic Fatty Liver DiseasePediatrics, 124
Yu-min Liu, Xiong-Jun Wang, A. Nawaz, Zhaohong Kong, Yanzhong Hong, Changhe Wang, Jun-jian Zhang (2011)
Wogonin ameliorates lipotoxicity-induced apoptosis of cultured vascular smooth muscle cells via interfering with DAG-PKC pathway, 32
A. Vries, P. Ruggenenti, X. Ruan, M. Praga, J. Cruzado, I. Bajema, V. D’Agati, H. Lamb, D. Barlovič, R. Hojs, M. Abbate, Rosa Rodriquez, C. Mogensen, E. Porrini (2014)
Fatty kidney: emerging role of ectopic lipid in obesity-related renal disease.The lancet. Diabetes & endocrinology, 2 5
T. Hinds, K. Burns, P. Hosick, L. McBeth, A. Nestor-Kalinoski, H. Drummond, Abdulhadi Alamodi, Michael Hankins, J. Heuvel, D. Stec (2016)
Biliverdin Reductase A Attenuates Hepatic Steatosis by Inhibition of Glycogen Synthase Kinase (GSK) 3β Phosphorylation of Serine 73 of Peroxisome Proliferator-activated Receptor (PPAR) α*The Journal of Biological Chemistry, 291
Min-Sun Kwak, Donghee Kim, G. Chung, S. Kang, M. Park, Y. Kim, Jung‐Hwan Yoon, Hyo‐suk Lee (2012)
Serum bilirubin levels are inversely associated with nonalcoholic fatty liver diseaseClinical and molecular hepatology, 18
H. Yokoi, M. Yanagita (2016)
Targeting the fatty acid transport protein CD36, a class B scavenger receptor, in the treatment of renal disease.Kidney international, 89 4
Cristina Martínez-García, Adriana Izquierdo-Lahuerta, Yurena Vivas, Ismael Velasco, T. Yeo, Sheldon Chen, G. Medina-Gómez (2015)
Renal Lipotoxicity-Associated Inflammation and Insulin Resistance Affects Actin Cytoskeleton Organization in PodocytesPLoS ONE, 10
D. Bauer, Matthew Canver, S. Orkin (2014)
Generation of genomic deletions in mammalian cell lines via CRISPR/Cas9.Journal of visualized experiments : JoVE, 95
Yaxi Chen, Z. Varghese, X. Ruan (2014)
The molecular pathogenic role of inflammatory stress in dysregulation of lipid homeostasis and hepatic steatosisGenes & Diseases, 1
Mariko Soumura, S. Kume, K. Isshiki, N. Takeda, S. Araki, Yuki Tanaka, T. Sugimoto, Masami Chin‐Kanasaki, Y. Nishio, M. Haneda, D. Koya, A. Kashiwagi, H. Maegawa, T. Uzu (2010)
Oleate and eicosapentaenoic acid attenuate palmitate-induced inflammation and apoptosis in renal proximal tubular cell.Biochemical and biophysical research communications, 402 2
Z. Jenko-Pražnikar, A. Petelin, Mihaela Jurdana, L. Žiberna (2013)
Serum bilirubin levels are lower in overweight asymptomatic middle-aged adults: an early indicator of metabolic syndrome?Metabolism: clinical and experimental, 62 7
H. Kang, S. Ahn, Peter Choi, Y. Ko, S. Han, Frank Chinga, Ae Park, Jianling Tao, K. Sharma, J. Pullman, E. Bottinger, I. Goldberg, K. Suszták (2014)
Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis developmentNature Medicine, 21
D. Bolignano, G. Coppolino, S. Campo, Carmela Aloisi, G. Nicocia, N. Frisina, M. Buemi (2007)
Neutrophil Gelatinase-Associated Lipocalin in Patients with Autosomal-Dominant Polycystic Kidney DiseaseAmerican Journal of Nephrology, 27
E. Rigney, O. Phillips, T. Mantle (1988)
Some physical and immunological properties of ox kidney biliverdin reductase.The Biochemical journal, 255 2
M. Maines (2007)
Biliverdin reductase: PKC interaction at the cross-talk of MAPK and PI3K signaling pathways.Antioxidants & redox signaling, 9 12
Michael Hall, J. Carmo, Alexandre Silva, L. Juncos, Zhen Wang, J. Hall
International Journal of Nephrology and Renovascular Disease Dovepress Obesity, Hypertension, and Chronic Kidney Disease
S. Datta, H. Dudek, Xu Tao, S. Masters, H. Fu, Y. Gotoh, M. Greenberg (1997)
Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death MachineryCell, 91
Urszula Florczyk, S. Gołda, Agata Zięba, J. Cisowski, A. Józkowicz, J. Dulak (2011)
Overexpression of biliverdin reductase enhances resistance to chemotherapeutics.Cancer letters, 300 1
Elias Katsoulieris, J. Mabley, Mohamed Samai, M. Sharpe, I. Green, P. Chatterjee (2010)
Lipotoxicity in renal proximal tubular cells: relationship between endoplasmic reticulum stress and oxidative stress pathways.Free radical biology & medicine, 48 12
M. Maines (2005)
New insights into biliverdin reductase functions: linking heme metabolism to cell signaling.Physiology, 20
L. Belo, H. Nascimento, M. Kohlová, E. Bronze-da-Rocha, J. Fernandes, E. Costa, C. Catarino, L. Aires, H. Mansilha, P. Rocha-Pereira, A. Quintanilha, C. Rêgo, A. Santos-Silva (2014)
Body Fat Percentage Is a Major Determinant of Total Bilirubin Independently of UGT1A1*28 Polymorphism in Young ObesePLoS ONE, 9
A. Herms, M. Bosch, N. Ariotti, Babu Reddy, A. Fajardo, Andrea Fernández-Vidal, A. Alvarez-Guaita, M. Fernández-Rojo, Carles Rentero, F. Tebar, C. Enrich, M. Geli, R. Parton, S. Gross, A. Pol (2013)
Cell-to-Cell Heterogeneity in Lipid Droplets Suggests a Mechanism to Reduce LipotoxicityCurrent Biology, 23
M. Herman-Edelstein, P. Scherzer, A. Tobar, M. Levi, U. Gafter (2014)
Altered renal lipid metabolism and renal lipid accumulation in human diabetic nephropathyJournal of Lipid Research, 55
G. Danaei, Yuan Lu, Gitanjali Singh, Emily Carnahan, Gretchen Stevens, Melanie Cowan, F. Farzadfar, J. Lin, M. Finucane, M. Rao, Y. Khang, L. Riley, Dariush Arian, Stephen Lim, M. Ezzati, G. Aamodt, Z. Abdeen, N. Abdella, H. Rahim, J. Addo, W. Aekplakorn, Mustafa Afifi, E. Agabiti-Rosei, C. Salinas, C. Agyemang, Mohammed Ali, Mohamed Ali, M. Al-Nsour, A. Al-Nuaim, Ramachandran Ambady, E. Angelantonio, P. Aro, F. Azizi, B. Babu, A. Bahalim, C. Barbagallo, M. Barbieri, A. Barceló, S. Barreto, H. Barros, L. Bautista, A. Benetos, P. Bjerregaard, C. Björkelund, Simona Bo, M. Bobák, E. Bonora, M. Botana, P. Bovet, Juergen Breckenkamp, M. Breteler, G. Broda, Ian Brown, M. Bursztyn, A. León, H. Campos, F. Cappuccio, V. Capuano, E. Casiglia, M. Castellano, K. Castetbon, L. Cea, Chih Chang, N. Chaouki, S. Chatterji, Chien-Jen Chen, Zhengming Chen, Jin Choi, Lily Chua, R. Cífková, L. Cobiac, R. Cooper, A. Corsi, M. Costanza, C. Craig, R. Dankner, S. Dastgiri, E. Delgado, G. Dinç, Y. Doi, G. Dong, E. d’Orsi, N. Dragano, A. Drewnowski, R. Eggertsen, P. Elliott, A. Engeland, C. Erem, A. Esteghamati, C. Fall, Jianxue Fan, C. Ferreccio, L. Fezeu, J. Firmo, H. Florez, N. Fornés, F. Fowkes, G. Franceschini, F. Frisk, F. Fuchs, E. Fuller, L. Getz, S. Giampaoli, L. Gómez, J. Gómez-Zumaquero, Sidsel Iversen, Janet Grant, Ramiro Carvajal, M. Gulliford, Rajeev Gupta, P. Gupta, O. Gureje, H. Gutierrez, T. Hansen, J. Hata, Jiang He, N. Heim, J. Heinrich, T. Hemmingsson, A. Hennis, W. Herman, V. Herrera, S. Ho, M. Holdsworth, G. Frisman, W. Hopman, A. Hussain, A. Husseini, M. Ibrahim, Nayu Ikeda, B. Jacobsen, H. Jaddou, T. Jafar, M. Janghorbani, G. Jasienska, M. Joffres, J. Jonas, O. Kadiki, O. Kalter‐Leibovici, R. Kamadjeu, S. Kaptoge, I. Karalis, M. Kastarinen, J. Katz, L. Keinan-Boker, P. Kelly, O. Khalilzadeh, S. Kiechl, Ki Kim, Y. Kiyohara, J. Kobayashi, Maressa Krause, R. Kubínová, P. Kurjata, Y. Kusuma, T. Lam, A. Langhammer, C. Lawes, C. Le, J. Lee, C. Lévy‐Marchal, S. Lewington, Yanping Li, Yuqiu Li, T. Lim, Xu Lin, Cheng-Chieh Lin, Hsien-Ho Lin, L. Lind, L. Lissner, Xiaoqing Liu, P. López-Jaramillo, R. Lorbeer, G. Ma, Stefan Ma, F. Macià, D. Maclean, S. Maggi, D. Magliano, Marcia Makdisse, G. Mancia, T. Mannami, P. Marques-Vidal, J. Mbanya, N. McFarlane‐Anderson, R. Miccoli, J. Miettola, H. Minh, J. Miquel, J. Miranda, M. Mohamed, V. Mohan, S. Mohanna, A. Mokdad, W. Mollentze, D. Morales, K. Morgan, M. Muiesan, S. Muntoni, I. Nabipour, T. Nakagami, V. Nangia, B. Nemesure, M. Neovius, K. Nerhus, F. Nervi, H. Neuhauser, Minh Nguyen, T. Ninomiya, M. Noale, Sang Oh, T. Ohkubo, O. Olivieri, A. Önal, A. Onat, M. Oróstegui, H. Ouédraogo, W. Pan, D. Panagiotakos, F. Panza, Yongsoo Park, V. Passos, M. Pednekar, P. Pelizzari, M. Peres, Pérez Pérez, R. Perez-Fernandez, R. Pichardo, H. Phua, F. Pistelli, P. Plans, M. Polakowska, N. Poulter, D. Prabhakaran, Q. Qiao, M. Rafiei, O. Raitakari, L. Ramos, S. Rampal, L. Rampal, F. Rasmussen, K. Reddy, J. Redón, Luis Revilla, V. Reyes‐García, Ragab Roaeid, C. Robinson, F. Rodríguez‐Artalejo, R. Rojas-Martínez, Kimmo Ronkainen, L. Rosero-Bixby, Gregory Roth, H. Sachdev, José Sánchez, S. Sanisoğlu, S. Sans, N. Sarrafzadegan, M. Scazufca, B. Schaan, N. Schapochnik, H. Schelleman, I. Schneider, C. Schooling, Bernhard Schwarz, C. Şekuri, M. Sereday, L. Serra-Majem, J. Shaw, A. Shera, Zumin Shi, R. Shiri, X. Shu, D. Silva, Eglé Silva, L. Simons, Margaret Smith, S. Söderberg, S. Soebardi, V. Solfrizzi, E. Sonestedt, A. Soysal, P. Stattin, A. Stein, G. Stergiou, J. Stessman, A. Sudo, M. Suka, V. Sundh, K. Sundquist, J. Sundström, A. Swai, E. Tai, K. Tambs, F. Tesfaye, G. Thomas, M. Thorogood, R. Tilvis, M. Tobias, L. Torheim, P. Trenkwalder, J. Tuomilehto, J. Tur, C. Tzourio, A. Uhernik, F. Ukoli, N. Unwin, S. Hoorn, M. Vanderpump, J. Varo, M. Veierød, G. Velásquez-Melendez, M. Verschuren, Lucie Viet, S. Villalpando, J. Vioque, P. Vollenweider, S. Volpato, Ningli Wang, Y. Wang, M. Ward, S. Waspadji, X. Welin, G. Whitlock, L. Wilhelmsen, J. Willeit, M. Woodward, D. Wormser, J. Xavier, Fei Xu, Liang Xu, A. Yamamoto, Gonghuan Yang, Xiaoguang Yang, L. Yeh, Jin-Sang Yoon, Q. You, Z. Yu, Jian Zhang, Lei Zhang, W. Zheng, Maigeng Zhou (2014)
Cardiovascular disease, chronic kidney disease, and diabetes mortality burden of cardiometabolic risk factors from 1980 to 2010: a comparative risk assessment.The lancet. Diabetes & endocrinology, 2 8
K. Puri, V. Nobili, K. Melville, C. Corte, M. Sartorelli, R. Lopez, A. Feldstein, N. Alkhouri (2013)
Serum Bilirubin Level Is Inversely Associated With Nonalcoholic Steatohepatitis in ChildrenJournal of Pediatric Gastroenterology and Nutrition, 57
L. Mandel (1985)
Metabolic substrates, cellular energy production, and the regulation of proximal tubular transport.Annual review of physiology, 47
J. Zha, H. Harada, E. Yang, J. Jockel, S. Korsmeyer (1996)
Serine Phosphorylation of Death Agonist BAD in Response to Survival Factor Results in Binding to 14-3-3 Not BCL-XLCell, 87
ME Hall, JM do Carmo, AA da Silva, LA Juncos, Z Wang, JE Hall (2014)
Obesity, hypertension, and chronic kidney disease, 7
Abdul-Rizaq Hamoud, L. Weaver, D. Stec, T. Hinds (2018)
Bilirubin in the Liver–Gut Signaling AxisTrends in Endocrinology & Metabolism, 29
T. Hinds, K. Sodhi, Charles Meadows, Larisa Fedorova, N. Puri, Dong Kim, S. Peterson, J. Shapiro, N. Abraham, A. Kappas (2013)
Increased HO-1 Levels Ameliorate Fatty Liver Development Through a Reduction of Heme and Recruitment of FGF21Obesity (Silver Spring, Md.), 22
F. Karadag, C. Sengul, Y. Enli, Kamuran Karakulah, H. Alacam, B. Kaptanoǧlu, Ozgur Kalkanci, H. Herken (2017)
Relationship between Serum Bilirubin Levels and Metabolic Syndrome in Patients with Schizophrenia Spectrum DisordersClinical Psychopharmacology and Neuroscience, 15
J. Lu, M. Molnar, Adnan Naseer, Margit Mikkelsen, K. Kalantar-Zadeh, C. Kovesdy (2015)
Association of age and BMI with kidney function and mortality: a cohort study.The lancet. Diabetes & endocrinology, 3 9
J. Mishra, Q. Ma, A. Prada, M. Mitsnefes, K. Zahedi, Jun Yang, J. Barasch, P. Devarajan (2003)
Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury.Journal of the American Society of Nephrology : JASN, 14 10
S. Adeosun, Kyle Moore, D. Lang, Assumpta Nwaneri, T. Hinds, D. Stec (2018)
A Novel Fluorescence-Based Assay for the Measurement of Biliverdin Reductase Activity.Reactive oxygen species, 5 13
D. Stec, K. John, Christopher Trabbic, Amarjit Luniwal, Michael Hankins, J. Baum, T. Hinds (2016)
Bilirubin Binding to PPARα Inhibits Lipid AccumulationPLoS ONE, 11
Katalin Susztak, Emilio Ciccone, Peter McCue, Kumar Sharma, Erwin Böttinger (2005)
Multiple Metabolic Hits Converge on CD36 as Novel Mediator of Tubular Epithelial Apoptosis in Diabetic NephropathyPLoS Medicine, 2
N. Abumrad, C. Coburn, A. Ibrahimi (1999)
Membrane proteins implicated in long-chain fatty acid uptake by mammalian cells: CD36, FATP and FABPm.Biochimica et biophysica acta, 1441 1
L. Peso, M. González‐García, C. Page, R. Herrera, G. Núñez (1997)
Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt.Science, 278 5338
L. Weaver, Abdul-Rizaq Hamoud, D. Stec, T. Hinds (2018)
Biliverdin reductase and bilirubin in hepatic disease.American journal of physiology. Gastrointestinal and liver physiology, 314 6
T. Haverty, C. Kelly, W. Hines, P. Amenta, M. Watanabe, R. Harper, N. Kefalides, E. Neilson (1988)
Characterization of a renal tubular epithelial cell line which secretes the autologous target antigen of autoimmune experimental interstitial nephritisThe Journal of Cell Biology, 107
Luke O’Brien, P. Hosick, K. John, D. Stec, T. Hinds (2015)
Biliverdin reductase isozymes in metabolismTrends in Endocrinology & Metabolism, 26
J. Mishra, K. Mori, Q. Ma, C. Kelly, J. Barasch, P. Devarajan (2004)
Neutrophil Gelatinase-Associated Lipocalin: A Novel Early Urinary Biomarker for Cisplatin NephrotoxicityAmerican Journal of Nephrology, 24
Ramesh Kumar, A. Rastogi, J. Maras, S. Sarin (2012)
Unconjugated hyperbilirubinemia in patients with non-alcoholic fatty liver disease: a favorable endogenous response.Clinical biochemistry, 45 3
Obesity and increased lipid availability have been implicated in the development and progression of chronic kidney disease. One of the major sites of renal lipid accumulation is in the proximal tubule cells of the kidney, suggesting that these cells may be susceptible to lipotoxicity. We previously demonstrated that loss of hepatic biliverdin reductase A (BVRA) causes fat accumulation in livers of mice on a high-fat diet. To determine the role of BVRA in mouse proximal tubule cells, we generated a CRISPR targeting BVRA for a knockout in mouse proximal tubule cells (BVRA KO). The BVRA KO cells had significantly less metabolic potential and mitochondrial respiration, which was exacerbated by treatment with palmitic acid, a saturated fatty acid. The BVRA KO cells also showed increased intracellular triglycerides which were associated with higher fatty acid uptake gene cluster of differentiation 36 as well as increased de novo lipogenesis as measured by higher neutral lipids. Additionally, neutrophil gelatinase-associated lipocalin 1 expression, annexin-V FITC staining, and lactate dehydrogenase assays all demonstrated that BVRA KO cells are more sensitive to palmitic acid-induced lipotoxicity than wild-type cells. Phosphorylation of BAD which plays a role in cell survival pathways, was significantly reduced in palmitic acid-treated BVRA KO cells. These data demonstrate the protective role of BVRA in proximal tubule cells against saturated fatty acid-induced lipotoxicity and suggest that activating BVRA could provide a benefit in protecting from obesity-induced kidney injury.
American Journal of Physiology-Renal Physiology – The American Physiological Society
Published: Aug 1, 2018
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.