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Landscape of GPCR expression along the mouse nephron

Landscape of GPCR expression along the mouse nephron Kidney transport and other renal functions are regulated by multiple G protein-coupled receptors (GPCRs) expressed along the renal tubule. The rapid, recent appearance of comprehensive unbiased gene expression data in the various renal tubule segments, chiefly RNA-seq and protein mass spectrometry data, has provided a means of identifying patterns of GPCR expression along the renal tubule. To allow for comprehensive mapping, we first curated a comprehensive list of GPCRs in the genomes of mice, rats, and humans (https://hpcwebapps.cit.nih.gov/ESBL/Database/GPCRs/), using multiple online data sources. We used this list to mine segment-specific and cell-type specific expression data from RNA-seq studies in microdissected mouse tubule segments to identify GPCRs that are selectively expressed in discrete tubule segments. Comparisons of these mapped mouse GPCRs with other omics datasets as well as functional data from isolated perfused tubule and micro-puncture studies confirms patterns of expression for well-known receptors and identifies poorly studied GPCRs that are likely to play roles in regulation of renal tubule function. Thus, we provide data resources for GPCR expression across the renal tubule, highlighting both well-known GPCRs and understudied receptors in order to provide guidance for future studies. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Physiology-Renal Physiology The American Physiological Society

Landscape of GPCR expression along the mouse nephron

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ISSN
1931-857x
eISSN
1522-1466
DOI
10.1152/ajprenal.00077.2021
Publisher site
See Article on Publisher Site

Abstract

Kidney transport and other renal functions are regulated by multiple G protein-coupled receptors (GPCRs) expressed along the renal tubule. The rapid, recent appearance of comprehensive unbiased gene expression data in the various renal tubule segments, chiefly RNA-seq and protein mass spectrometry data, has provided a means of identifying patterns of GPCR expression along the renal tubule. To allow for comprehensive mapping, we first curated a comprehensive list of GPCRs in the genomes of mice, rats, and humans (https://hpcwebapps.cit.nih.gov/ESBL/Database/GPCRs/), using multiple online data sources. We used this list to mine segment-specific and cell-type specific expression data from RNA-seq studies in microdissected mouse tubule segments to identify GPCRs that are selectively expressed in discrete tubule segments. Comparisons of these mapped mouse GPCRs with other omics datasets as well as functional data from isolated perfused tubule and micro-puncture studies confirms patterns of expression for well-known receptors and identifies poorly studied GPCRs that are likely to play roles in regulation of renal tubule function. Thus, we provide data resources for GPCR expression across the renal tubule, highlighting both well-known GPCRs and understudied receptors in order to provide guidance for future studies.

Journal

American Journal of Physiology-Renal Physiology – The American Physiological Society

Published: Jul 1, 2021

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  • Human distribution and release of a putative new gut hormone, peptide YY
    Adrian, TE; Ferri, GL; Bacarese-Hamilton, AJ; Fuessl, HS; Polak, JM; Bloom, SR
  • The pancreatic polypeptide (PP-Fold) family: gastrointestinal, vascular, and feeding behavioral implications
    Hazelwood, RL
  • Localization of neuropeptide Y and its C-terminal flanking peptide in human renal tissue
    Grouzmann, E; Alvarez-Bolado, G; Meyer, C; Osterheld, MC; Burnier, M; Brunner, HR; Waeber, B
  • Mechanism of neuropeptide Y inhibition of vasopressin action in rat cortical collecting tubule
    Dillingham, MA; Anderson, RJ
  • Role of neuropeptide Y in the regulation of kidney function
    Winaver, J; Abassi, Z; Zukowska, Z; Feuerstein, GZ.
  • Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF
    Filardo, EJ; Quinn, JA; Bland, KI; Frackelton, AR
  • Discovery of three novel G-protein-coupled receptor genes
    O'Dowd, BF; Nguyen, T; Marchese, A; Cheng, R; Lynch, KR; Heng, HH; Kolakowski, LF; George, SR
  • A transmembrane intracellular estrogen receptor mediates rapid cell signaling
    Revankar, CM; Cimino, DF; Sklar, LA; Arterburn, JB; Prossnitz, ER
  • Mapping of sex hormone receptors and their modulators along the nephron of male and female mice
    Grimont, A; Bloch-Faure, M; El Abida, B; Crambert, G
  • Rapid aldosterone-mediated signaling in the DCT increases activity of the thiazide-sensitive NaCl cotransporter
    Cheng, L; Poulsen, SB; Wu, Q; Esteva-Font, C; Olesen, ETB; Peng, L; Olde, B; Leeb-Lundberg, LMF; Pisitkun, T; Rieg, T; Dimke, H; Fenton, RA
  • G protein-coupled estrogen receptor 1 as a novel regulator of blood pressure
    Gohar, EY
  • Migration of CD4 T cells and dendritic cells toward sphingosine 1-phosphate (S1P) is mediated by different receptor subtypes: S1P regulates the functions of murine mature dendritic cells via S1P receptor type 3
    Maeda, Y; Matsuyuki, H; Shimano, K; Kataoka, H; Sugahara, K; Chiba, K
  • Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5
    Ancellin, N; Hla, T
  • Orphan GPR110 (ADGRF1) targeted by N-docosahexaenoylethanolamine in development of neurons and cognitive function
    Lee, JW; Huang, BX; Kwon, H; Rashid, MA; Kharebava, G; Desai, A; Patnaik, S; Marugan, J; Kim, HY
  • Adhesion G protein-coupled receptors: opportunities for drug discovery
    Bassilana, F; Nash, M; Ludwig, MG
  • Adhesion GPCRs in kidney development and disease
    Cazorla-Vázquez, S; Engel, FB
  • Mechanisms of adhesion G protein-coupled receptor activation
    Vizurraga, A; Adhikari, R; Yeung, J; Yu, M; Tall, GG
  • Activation of adhesion G protein-coupled receptors: agonist specificity of stachel sequence-derived peptides
    Demberg, LM; Winkler, J; Wilde, C; Simon, KU; Schon, J; Rothemund, S; Schoneberg, T; Promel, S; Liebscher, I
  • A forward chemical genetic screen reveals gut microbiota metabolites that modulate host physiology
    Chen, H; Nwe, PK; Yang, Y; Rosen, CE; Bielecka, AA; Kuchroo, M; Cline, GW; Kruse, AC; Ring, AM; Crawford, JM; Palm, NW
  • G protein-coupled receptor 56 and collagen III, a receptor-ligand pair, regulates cortical development and lamination
    Luo, R; Jeong, SJ; Jin, Z; Strokes, N; Li, S; Piao, X
  • The adhesion GPCR latrophilin/CIRL shapes mechanosensation
    Scholz, N; Gehring, J; Guan, C; Ljaschenko, D; Fischer, R; Lakshmanan, V; Kittel, RJ; Langenhan, T
  • LPA receptor heterodimerizes with CD97 to amplify LPA-initiated RHO-dependent signaling and invasion in prostate cancer cells
    Ward, Y; Lake, R; Yin, JJ; Heger, CD; Raffeld, M; Goldsmith, PK; Merino, M; Kelly, K
  • Interstitial fibrosis in obstructive nephropathy
    Sharma, AK; Mauer, SM; Kim, Y; Michael, AF
  • Characterization and functional study of a cluster of four highly conserved orphan adhesion-GPCR in mouse
    Promel, S; Waller-Evans, H; Dixon, J; Zahn, D; Colledge, WH; Doran, J; Carlton, MB; Grosse, J; Schoneberg, T; Russ, AP; Langenhan, T
  • Analysis of CD97 expression and manipulation: antibody treatment but not gene targeting curtails granulocyte migration
    Veninga, H; Becker, S; Hoek, RM; Wobus, M; Wandel, E; van der Kaa, J; van der Valk, M; de Vos, AF; Haase, H; Owens, B; van der Poll, T; van Lier, RA; Verbeek, JS; Aust, G; Hamann, J
  • Gpr97 exacerbates AKI by mediating Sema3A signaling
    Fang, W; Wang, Z; Li, Q; Wang, X; Zhang, Y; Sun, Y; Tang, W; Ma, C; Sun, J; Li, N; Yi, F
  • Structures of the glucocorticoid-bound adhesion receptor GPR97-Go complex
    Ping, YQ; Mao, C; Xiao, P; Zhao, RJ; Jiang, Y; Yang, Z; An, WT; Shen, DD; Yang, F; Zhang, H; Qu, C; Shen, Q; Tian, C; Li, ZJ; Li, S; Wang, GY; Tao, X; Wen, X; Zhong, YN; Yang, J; Yi, F; Yu, X; Xu, HE; Zhang, Y; Sun, JP
  • Colocalization of H+-ATPase and band 3 anion exchanger in rabbit collecting duct intercalated cells
    Schuster, VL; Fejes-Toth, G; Naray-Fejes-Toth, A; Gluck, S
  • Neural control of renal function
    DiBona, GF; Kopp, UC
  • Effect of catecholamines on fluid reabsorption by the isolated proximal convoluted tubule
    Bello-Reuss, E
  • Alpha 2 adrenergic agonists stimulate Na+-H+ antiport activity in the rabbit renal proximal tubule
    Nord, EP; Howard, MJ; Hafezi, A; Moradeshagi, P; Vaystub, S; Insel, PA
  • Evidence that alpha-1-adrenergic stimuli specifically increase gluconeogenesis of the isolated proximal convoluted tubule in the rat
    Nakada, J; Yamada, H; Endou, H
  • Inhibition of α2-adrenergic agonists on AVP-induced cAMP accumulation in isolated collecting tubule of the rat kidney
    Chabardès, D; Montégut, M; Imbert-Teboul, M; Morel, F
  • Functional characterization of the alpha adrenergic receptor modulating the hydroosmotic effect of vasopressin on the rabbit cortical collecting tubule
    Krothapalli, RK; Suki, WN
  • Modulation of the hydro-osmotic effect of vasopressin on the rabbit cortical collecting tubule by adrenergic agents
    Krothapalli, RK; Duffy, WB; Senekjian, HO; Suki, WN
  • Effects of catecholamines on electrolyte transport in cortical collecting tubule
    Iino, Y; Troy, JL; Brenner, BM
  • Sympathetic stimulation of thiazide-sensitive sodium chloride cotransport in the generation of salt-sensitive hypertension
    Terker, AS; Yang, CL; McCormick, JA; Meermeier, NP; Rogers, SL; Grossmann, S; Trompf, K; Delpire, E; Loffing, J; Ellison, DH
  • Norepinephrine-induced stimulation of Kir4.1/Kir5.1 is required for the activation of NaCl transporter in distal convoluted tubule
    Duan, XP; Gu, L; Xiao, Y; Gao, ZX; Wu, P; Zhang, YH; Meng, XX; Wang, JL; Zhang, DD; Lin, DH; Wang, WH; Gu, R
  • Renin release from isolated afferent arterioles
    Itoh, S; Carretero, OA; Murray, RD
  • Beta2-adrenergic receptor in kidney biology: a current prospective
    Arif, E; Nihalani, D
  • Role of α2-adrenoceptors in hypertension: focus on renal sympathetic neurotransmitter release, inflammation, and sodium homeostasis
    Hering, L; Rahman, M; Potthoff, SA; Rump, LC; Stegbauer, J
  • Renal sympathetic nerve-derived signaling in acute and chronic kidney diseases
    Noh, MR; Jang, HS; Kim, J; Padanilam, BJ
  • LPA receptor signaling: pharmacology, physiology, and pathophysiology
    Yung, YC; Stoddard, NC; Chun, J
  • Lysophosphatidic acid signaling in diabetic nephropathy
    Lee, JH; Kim, D; Oh, YS; Jun, HS
  • Blocking lysophosphatidic acid receptor 1 signaling inhibits diabetic nephropathy in db/db mice
    Li, HY; Oh, YS; Choi, JW; Jung, JY; Jun, HS
  • EGF and angiotensin II modulate lysophosphatidic acid LPA1 receptor function and phosphorylation state
    Colín-Santana, CC; Avendaño-Vázquez, SE; Alcántara-Hernández, R; García-Sáinz, JA
  • Defining an olfactory receptor function in airway smooth muscle cells
    Aisenberg, WH; Huang, J; Zhu, W; Rajkumar, P; Cruz, R; Santhanam, L; Natarajan, N; Yong, HM; De Santiago, B; Oh, JJ; Yoon, AR; Panettieri, RA; Homann, O; Sullivan, JK; Liggett, SB; Pluznick, JL; An, SS
  • Olfactory, taste, and photo sensory receptors in non-sensory organs: it just makes sense
    Dalesio, NM; Barreto, OS; Pluznick, JL; Berkowitz, DE
  • Characterization of the olfactory receptors expressed in human spermatozoa
    Flegel, C; Vogel, F; Hofreuter, A; Schreiner, BS; Osthold, S; Veitinger, S; Becker, C; Brockmeyer, NH; Muschol, M; Wennemuth, G; Altmuller, J; Hatt, H; Gisselmann, G
  • Therapeutic potential of ectopic olfactory and taste receptors
    Lee, SJ; Depoortere, I; Hatt, H
  • Characterizing novel olfactory receptors expressed in the murine renal cortex
    Halperin Kuhns, VL; Sanchez, J; Sarver, DC; Khalil, Z; Rajkumar, P; Marr, KA; Pluznick, JL
  • Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation
    Pluznick, JL; Protzko, RJ; Gevorgyan, H; Peterlin, Z; Sipos, A; Han, J; Brunet, I; Wan, LX; Rey, F; Wang, T; Firestein, SJ; Yanagisawa, M; Gordon, JI; Eichmann, A; Peti-Peterdi, J; Caplan, MJ
  • Functional expression of the olfactory signaling system in the kidney
    Pluznick, JL; Zou, D-J; Zhang, X; Yan, Q; Rodriguez-Gil, DJ; Eisner, C; Wells, E; Greer, CA; Wang, T; Firestein, S; Schnermann, J; Caplan, MJ
  • A renal olfactory receptor aids in kidney glucose handling
    Shepard, BD; Cheval, L; Peterlin, Z; Firestein, S; Koepsell, H; Doucet, A; Pluznick, JL
  • Renal olfactory receptor 1393 contributes to the progression of type 2 diabetes in a diet-induced obesity model
    Shepard, BD; Koepsell, H; Pluznick, JL
  • Dopamine and renal function and blood pressure regulation
    Armando, I; Villar, VA; Jose, PA
  • Dopamine activates noradrenergic receptors in the preoptic area
    Cornil, CA; Balthazart, J; Motte, P; Massotte, L; Seutin, V
  • Dopamine mimics the cardioprotective effect of ischemic preconditioning via activation of α1-adrenoceptors in the isolated rat heart
    Lazou, A; Markou, T; Zioga, M; Vasara, E; Efstathiou, A; Gaitanaki, C
  • Selectivities of some agonists acting at α1- and α2-adrenoceptors in the rat vas deferens
    Leedham, JA; Pennefather, JN
  • Impact of angiotensin type 1A receptors in principal cells of the collecting duct on blood pressure and hypertension
    Chen, D; Stegbauer, J; Sparks, MA; Kohan, D; Griffiths, R; Herrera, M; Gurley, SB; Coffman, TM
  • Regulation of sodium transporters in the thick ascending limb of rat kidney: response to angiotensin II
    Kwon, T-H; Nielsen, J; Kim, Y-H; Knepper, MA; Frøkiær, J; Nielsen, S
  • Differential regulation of Na+ transporters along nephron during ANG II-dependent hypertension: distal stimulation counteracted by proximal inhibition
    Nguyen, MT; Lee, DH; Delpire, E; McDonough, AA
  • Role of the collecting duct renin angiotensin system in regulation of blood pressure and renal function
    Ramkumar, N; Kohan, DE
  • Effects of angiotensin II on electrolyte transport in the early and late distal tubule in rat kidney
    Wang, T; Giebisch, G
  • Single-cell transcriptome profiling of the kidney glomerulus identifies key cell types and reactions to injury
    Chung, JJ; Goldstein, L; Chen, YJ; Lee, J; Webster, JD; Roose-Girma, M; Paudyal, SC; Modrusan, Z; Dey, A; Shaw, AS
  • RNA-Seq profiling of microdissected glomeruli identifies potential biomarkers for human IgA nephropathy
    Park, S; Yang, SH; Jeong, CW; Moon, KC; Kim, DK; Joo, KW; Kim, YS; Lee, JW; Lee, H
  • An online resource for GPCR structure determination and analysis
    Munk, C; Mutt, E; Isberg, V; Nikolajsen, LF; Bibbe, JM; Flock, T; Hanson, MA; Stevens, RC; Deupi, X; Gloriam, DE