Access the full text.
Sign up today, get DeepDyve free for 14 days.
P. Ernsberger, R. Koletsky, J. Friedman (1999)
Molecular Pathology in the Obese Spontaneous Hypertensive Koletsky Rat: A Model of Syndrome XAnnals of the New York Academy of Sciences, 892
K. Okamoto, K. Aoki (1963)
Development of a strain of spontaneously hypertensive rats.Japanese circulation journal, 27
J. Osmond, J. Mintz, D. Stepp (2010)
Preventing increased blood pressure in the obese Zucker rat improves severity of stroke.American journal of physiology. Heart and circulatory physiology, 299 1
S. Prabhakar, J. Starnes, S. Shi, B. Lonis, R. Tran (2007)
Diabetic nephropathy is associated with oxidative stress and decreased renal nitric oxide production.Journal of the American Society of Nephrology : JASN, 18 11
A. Geurts, G. Cost, Yevgeniy Freyvert, B. Zeitler, Jeffrey Miller, Vivian Choi, Shirin Jenkins, Adam Wood, X. Cui, Xiangdong Meng, Anna Vincent, Stephen Lam, M. Michalkiewicz, Rebecca Schilling, J. Foeckler, S. Kalloway, H. Weiler, S. Ménoret, I. Anegon, G. Davis, Lei Zhang, E. Rebar, P. Gregory, F. Urnov, H. Jacob, R. Buelow (2009)
Knockout Rats via Embryo Microinjection of Zinc-Finger NucleasesScience, 325
O. Rafikova, E. Salah, S. Tofovic (2008)
Renal and metabolic effects of tempol in obese ZSF1 rats--distinct role for superoxide and hydrogen peroxide in diabetic renal injury.Metabolism: clinical and experimental, 57 10
Z. Ruben, J. Miller, E. Rohrbacher, G. Walsh (1984)
A potential model for a human disease: spontaneous cardiomyopathy-congestive heart failure in SHR/N-cp rats.Human pathology, 15 10
J. Siwy, C. Zoja, J. Klein, A. Benigni, Wiliam Mullen, B. Mayer, H. Mischak, J. Jankowski, R. Stevens, A. Vlahou, S. Kossida, P. Perco, F. Bahlmann (2012)
Evaluation of the Zucker Diabetic Fatty (ZDF) Rat as a Model for Human Disease Based on Urinary Peptidomic ProfilesPLoS ONE, 7
Anookh Mohanan, Ramesh Gupta, A. Dubey, Vikrant Jagtap, A. Mandhare, Ramesh Gupta, V. Chauthaiwale, C. Dutt (2011)
TRC120038, a Novel Dual AT1/ETA Receptor Blocker for Control of Hypertension, Diabetic Nephropathy, and Cardiomyopathy in ob-ZSF1 RatsInternational Journal of Hypertension, 2011
Hussen Machado, H. Pinheiro, M. Terra, M. Guerra, R. Paula, V. Peters (2012)
[Dissociation of antihypertensive and metabolic response to losartan and spironolactone in experimental rats with metabolic sindrome].Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia, 34 4
Victor Bilan, E. Salah, S. Bastacky, H. Jones, R. Mayers, B. Zinker, S. Poucher, S. Tofovic (2011)
Diabetic nephropathy and long-term treatment effects of rosiglitazone and enalapril in obese ZSF1 rats.The Journal of endocrinology, 210 3
N. Auberval, S. Dal, W. Bietiger, M. Pinget, N. Jeandidier, E. Maillard-Pedracini, V. Schini-Kerth, S. Sigrist (2014)
Metabolic and oxidative stress markers in Wistar rats after 2 months on a high-fat dietDiabetology & Metabolic Syndrome, 6
J. Hall, E. Crook, Daniel Jones, M. Wofford, P. Dubbert (2002)
Mechanisms of obesity-associated cardiovascular and renal disease.The American journal of the medical sciences, 324 3
M. Khan, J. Neckář, Breana Cummens, G. Wahl, J. Imig (2014)
Azilsartan Decreases Renal and Cardiovascular Injury in the Spontaneously Hypertensive Obese RatCardiovascular Drugs and Therapy, 28
J. Henegar, S. Bigler, Lisa Henegar, S. Tyagi, J. Hall (2001)
Functional and structural changes in the kidney in the early stages of obesity.Journal of the American Society of Nephrology : JASN, 12 6
Clause Bt (1998)
The Wistar Institute Archives: rats (not mice) and history.
P. Turnbaugh, F. Bäckhed, L. Fulton, J. Gordon (2008)
Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome.Cell host & microbe, 3 4
K. Griffin, M. Abu-Naser, I. Abu-Amarah, M. Picken, G. Williamson, A. Bidani (2007)
Dynamic blood pressure load and nephropathy in the ZSF1 (fa/fa cp) model of type 2 diabetes.American journal of physiology. Renal physiology, 293 5
Magdalena Alonso-Galicia, M. Brands, D. Zappe, J. Hall (1996)
Hypertension in obese Zucker rats. Role of angiotensin II and adrenergic activity.Hypertension, 28 6
T. Zucker, L. Zucker (1963)
Fat accretion and growth in the rat.The Journal of nutrition, 80
S. Mccune, P. Baker, H. Stills (1990)
SHHF/Mcc-cp Rat: Model of Obesity, Non-insulin-dependent Diabetes, and Congestive Heart FailureIlar Journal, 32
N. Ishizaka, Y. Ishizaka, E. Toda, K. Koike, G. Seki, R. Nagai, M. Yamakado (2007)
Association between Obesity and Chronic Kidney Disease in Japanese: Differences in Gender and Hypertensive Status?Hypertension Research, 30
G. Bray, D. York (1979)
Hypothalamic and genetic obesity in experimental animals: an autonomic and endocrine hypothesis.Physiological reviews, 59 3
R. Kelley, A. Bruce, Tom Spencer, Eric Werdin, R. Ilagan, Sumana Choudhury, Elias Rivera, Shay Wallace, K. Guthrie, M. Jayo, Fengfeng Xu, Anjali Rao, B. Humphreys, S. Presnell, T. Bertram (2013)
A Population of Selected Renal Cells Augments Renal Function and Extends Survival in the ZSF1 Model of Progressive Diabetic NephropathyCell Transplantation, 22
Jian Cao, Kazuyoshi Inoue, K. Sodhi, N. Puri, S. Peterson, R. Rezzani, N. Abraham (2012)
High‐Fat Diet Exacerbates Renal Dysfunction in SHR: Reversal by Induction of HO‐1–Adiponectin AxisObesity, 20
T. Coimbra, T. Coimbra, T. Coimbra, Ulf Janssen, Ulf Janssen, Ulf Janssen, H. Gröne, T. Ostendorf, T. Ostendorf, T. Ostendorf, U. Kunter, U. Kunter, U. Kunter, Hartmut Schmidt, Hartmut Schmidt, Hartmut Schmidt, G. Brabant, G. Brabant, G. Brabant, J. Floege, J. Floege, J. Floege (2000)
Early events leading to renal injury in obese Zucker (fatty) rats with type II diabetes.Kidney international, 57 1
K. Sandberg, H. Ji (2012)
Sex differences in primary hypertensionBiology of Sex Differences, 3
B. Swinburn, G. Sacks, K. Hall, K. McPherson, D. Finegood, M. Moodie, S. Gortmaker (2011)
The global obesity pandemic: shaped by global drivers and local environmentsThe Lancet, 378
Christian Dijk, Nynke Oosterhuis, Y. Xu, M. Brandt, W. Paulus, L. Heerebeek, D. Duncker, M. Verhaar, D. Fontoura, A. Lourenço, A. Leite-Moreira, I. Falcão-Pires, J. Joles, Caroline Cheng (2016)
Distinct Endothelial Cell Responses in the Heart and Kidney Microvasculature Characterize the Progression of Heart Failure With Preserved Ejection Fraction in the Obese ZSF1 Rat With Cardiorenal Metabolic SyndromeCirculation: Heart Failure, 9
S. Rabot, Mathieu Membrez, A. Bruneau, P. Gérard, T. Harach, M. Moser, F. Raymond, R. Mansourian, C. Chou (2010)
Germ-free C57BL/6J mice are resistant to high-fat-diet-induced insulin resistance and have altered cholesterol metabolism.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 24 12
F. Stevenson, C. Wheeldon, M. Gades, H. Goor, Judith Stern (2001)
Hyperphagia as a mediator of renal disease initiation in obese Zucker rats.Obesity research, 9 8
A. Neto, Felipe Rossi, Rodrigo Amarante, Nara Buriti, Gabriel Saheb, Marçal Rossi (2009)
Effect of weight loss after Roux-en-Y gastric bypass, on renal function and blood pressure in morbidly obese patients.Journal of nephrology, 22 5
Montani Jp, V. Antic, Zhihong Yang, A. Dulloo (2002)
Pathways from obesity to hypertension: from the perspective of a vicious triangleInternational Journal of Obesity, 26
J. Heyen, E. Blasi, K. Nikula, R. Rocha, H. Daust, G. Frierdich, J. Vleet, P. Ciechi, E. Mcmahon, A. Rudolph (2002)
Structural, functional, and molecular characterization of the SHHF model of heart failure.American journal of physiology. Heart and circulatory physiology, 283 5
P. Ernsberger, Janean Johnson, T. Rosenthal, D. Mirelman, R. Koletsky (2007)
Therapeutic actions of allylmercaptocaptopril and captopril in a rat model of metabolic syndrome.American journal of hypertension, 20 8
G. Chertow, Chi-yuan Hsu, K. Johansen (2006)
The enlarging body of evidence: obesity and chronic kidney disease.Journal of the American Society of Nephrology : JASN, 17 6
Rebecca Gelber, T. Kurth, A. Kausz, J. Manson, Julie Buring, A. Levey, J. Gaziano (2005)
Association between body mass index and CKD in apparently healthy men.American journal of kidney diseases : the official journal of the National Kidney Foundation, 46 5
R. Ley, F. Bäckhed, P. Turnbaugh, C. Lozupone, R. Knight, J. Gordon (2005)
Obesity alters gut microbial ecology.Proceedings of the National Academy of Sciences of the United States of America, 102 31
E. Ionescu, J. Sauter, B. Jeanrenaud (1985)
Abnormal oral glucose tolerance in genetically obese (fa/fa) rats.The American journal of physiology, 248 5 Pt 1
David White, Yanping Wang, Streamson Chua, Jay Morgenstern, Rudolph Leibel, Heinz Baumann, L. Tartaglia (1997)
Constitutive and impaired signaling of leptin receptors containing the Gln --> Pro extracellular domain fatty mutation.Proceedings of the National Academy of Sciences of the United States of America, 94 20
Jonathan Nizar, Wuxing Dong, Robert McClellan, M. Labarca, Yuehan Zhou, J. Wong, Donald Goens, Mingming Zhao, Nona Velarde, D. Bernstein, M. Pellizzon, L. Satlin, Vivek Bhalla (2016)
Na+-sensitive elevation in blood pressure is ENaC independent in diet-induced obesity and insulin resistance.American journal of physiology. Renal physiology, 310 9
Gerard D’Angelo, J. Mintz, J. Tidwell, A. Schreihofer, D. Pollock, D. Stepp (2006)
Exaggerated Cardiovascular Stress Responses and Impaired β-Adrenergic–Mediated Pressor Recovery in Obese Zucker RatsHypertension, 48
Di Zhang, Hong Huo, Yingnan Zhang, Q. Zeng (2007)
[Roles of 20-HETE on physiologic and pathologic regulation in organism].Sheng li ke xue jin zhan [Progress in physiology], 38 2
T. Ninomiya, Y. Kiyohara (2007)
Albuminuria and chronic kidney disease in association with the metabolic syndrome.Journal of the cardiometabolic syndrome, 2 2
F. Spradley, Kyu-Tae Kang, Jennifer Pollock (2013)
Short‐term hypercaloric diet induces blunted aortic vasoconstriction and enhanced vasorelaxation via increased nitric oxide synthase 3 activity and expression in Dahl salt‐sensitive ratsActa Physiologica, 207
Volker Vallon, K. Richter, R. Blantz, S. Thomson, Hartmut Osswald (1999)
Glomerular hyperfiltration in experimental diabetes mellitus: potential role of tubular reabsorption.Journal of the American Society of Nephrology : JASN, 10 12
L. Gallo, E. Wright, V. Vallon (2015)
Probing SGLT2 as a therapeutic target for diabetes: Basic physiology and consequencesDiabetes & Vascular Disease Research, 12
G. Youcef, A. Olivier, C. L'Huillier, C. Labat, R. Fay, Lina Tabcheh, S. Toupance, R. Rodriguez-Guéant, D. Bergerot, F. Jaisser, P. Lacolley, F. Zannad, Laurent Vallar, A. Pizard (2014)
Simultaneous Characterization of Metabolic, Cardiac, Vascular and Renal Phenotypes of Lean and Obese SHHF RatsPLoS ONE, 9
H. Komura, Ikuo Nomura, K. Kitamura, K. Kuwasako, J. Kato (2013)
Gender difference in relationship between body mass index and development of chronic kidney diseaseBMC Research Notes, 6
S. Knight, Jianghe Yuan, Siddhartha Roy, J. Imig (2008)
Simvastatin and Tempol Protect Against Endothelial Dysfunction and Renal Injury in a Model of Obesity and HypertensionThe FASEB Journal, 22
S. Chua, D. White, X. Wu-Peng, Shun-Mei Liu, Nori Okada, E. Kershaw, Wendy Chung, L. Power-Kehoe, M. Chua, L. Tartaglia, R. Leibel (1996)
Phenotype of fatty Due to Gln269Pro Mutation in the Leptin Receptor (Lepr)Diabetes, 45
Qingrong Pan, Yan-Long Ren, Jianhua Zhu, Yanjin Hu, Jin-Su Zheng, H. Fan, Yuan Xu, Guang Wang, Wen-Xian Liu (2014)
Resveratrol Increases Nephrin and Podocin Expression and Alleviates Renal Damage in Rats Fed a High-Fat DietNutrients, 6
J. Clark, Cathy Palmer, W. Shaw (1983)
The Diabetic Zucker Fatty RatProceedings of the Society for Experimental Biology and Medicine, 173
Anne-Émilie Declèves, A. Mathew, R. Cunard, K. Sharma (2011)
AMPK mediates the initiation of kidney disease induced by a high-fat diet.Journal of the American Society of Nephrology : JASN, 22 10
Abdul Khan, J. Imig (2011)
Telmisartan provides better renal protection than valsartan in a rat model of metabolic syndrome.American journal of hypertension, 24 7
S. Bagby (2004)
Obesity-initiated metabolic syndrome and the kidney: a recipe for chronic kidney disease?Journal of the American Society of Nephrology : JASN, 15 11
Asnawi Abdullah, F. Amin, F. Hanum, J. Stoelwinder, S. Tanamas, Rory Wolf, E. Wong, A. Peeters (2016)
Estimating the risk of type-2 diabetes using obese-years in a contemporary population of the Framingham StudyGlobal Health Action, 9
Donald Wesson, Neil Kurtzman, Pedro Frommer (1985)
Massive obesity and nephrotic proteinuria with a normal renal biopsy.Nephron, 40 2
C. Marques, M. Meireles, Sónia Norberto, J. Leite, Joana Freitas, D. Pestana, A. Faria, C. Calhau (2016)
High-fat diet-induced obesity Rat model: a comparison between Wistar and Sprague-Dawley RatAdipocyte, 5
Takuya Hattori, Tamayo Murase, Miwa Takatsu, Kai Nagasawa, Natsumi Matsuura, Shogo Watanabe, T. Murohara, K. Nagata (2014)
Dietary Salt Restriction Improves Cardiac and Adipose Tissue Pathology Independently of Obesity in a Rat Model of Metabolic SyndromeJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 3
W. Fenske, S. Dubb, M. Bueter, F. Seyfried, K. Patel, F. Tam, A. Frankel, C. Roux (2013)
Effect of bariatric surgery-induced weight loss on renal and systemic inflammation and blood pressure: a 12-month prospective study.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery, 9 4
K. Stemmer, D. Perez-Tilve, G. Ananthakrishnan, A. Bort, R. Seeley, M. Tschöp, D. Dietrich, P. Pfluger (2012)
High-fat-diet-induced obesity causes an inflammatory and tumor-promoting microenvironment in the rat kidneyDisease Models & Mechanisms, 5
Asphalt Mixes (2011)
DEVELOPMENT OF A
I. Wahba, R. Mak (2007)
Obesity and obesity-initiated metabolic syndrome: mechanistic links to chronic kidney disease.Clinical journal of the American Society of Nephrology : CJASN, 2 3
S. Grundy, D. Becker, L. Clark, R. Cooper, M. Denke, James Howard, D. Hunninghake, D. Illingworth, R. Luepker, P. Mcbride, J. Mckenney, R. Pasternak, N. Stone, L. Horn, H. Brewer, J. Cleeman, N. Ernst, D. Gordon, D. Levy, B. Rifkind, J. Rossouw, P. Savage, S. Haffner, D. Orloff, M. Proschan, J. Schwartz, C. Sempos, Susan Shero, Elaine Murray, Susan Keller, Angela Jehle, T. Ganiats, Gary Graham (2015)
National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
J. Saliba, Nader Kasim, Robyn Tamboli, J. Isbell, Pamela Marks, I. Feurer, Alp Ikizler, N. Abumrad (2010)
Roux-en-Y gastric bypass reverses renal glomerular but not tubular abnormalities in excessively obese diabetics.Surgery, 147 2
Shitalkumar Zambad, Siralee Munshi, A. Dubey, Ramesh Gupta, R. Busiello, A. Lanni, F. Goglia, Ramesh Gupta, V. Chauthaiwale, C. Dutt (2011)
TRC150094 attenuates progression of nontraditional cardiovascular risk factors associated with obesity and type 2 diabetes in obese ZSF1 ratsDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 4
P. Bravo, S. Morse, D. Borne, Erwin Aguilar, E. Reisin (2006)
Leptin and Hypertension in ObesityVascular Health and Risk Management, 2
A. Daniels, D. Linz, M. Bilsen, H. Rütten, T. Sadowski, S. Ruf, H. Juretschke, C. Neumann‐Haefelin, C. Munts, G. Vusse, F. Nieuwenhoven (2012)
Long‐term severe diabetes only leads to mild cardiac diastolic dysfunction in Zucker diabetic fatty ratsEuropean Journal of Heart Failure, 14
S. Seliger, C. Davis, C. Stehman-Breen (2001)
Gender and the progression of renal diseaseCurrent Opinion in Nephrology and Hypertension, 10
S. Navaneethan, Hans Yehnert (2009)
Bariatric surgery and progression of chronic kidney disease.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery, 5 6
J. Vora, S. Zimsen, D. Houghton, S. Anderson (1996)
Evolution of metabolic and renal changes in the ZDF/Drt-fa rat model of type II diabetes.Journal of the American Society of Nephrology : JASN, 7 1
J. Frisbee (2005)
Hypertension‐Independent Microvascular Rarefaction in the Obese Zucker Rat Model of the Metabolic SyndromeMicrocirculation, 12
J. Chen, P. Muntner, L. Hamm, Daniel Jones, V. Batuman, V. Fonseca, P. Whelton, Jiang He (2004)
The Metabolic Syndrome and Chronic Kidney Disease in U.S. AdultsAnnals of Internal Medicine, 140
A. Dobrian, S. Schriver, A. Khraibi, R. Prewitt (2004)
Pioglitazone Prevents Hypertension and Reduces Oxidative Stress in Diet-Induced ObesityHypertension: Journal of the American Heart Association, 43
Hui-mei Chen, Zhi-Hong Liu, C. Zeng, Shijun Li, Qing-wen Wang, Lei‐shi Li (2006)
Podocyte lesions in patients with obesity-related glomerulopathy.American journal of kidney diseases : the official journal of the National Kidney Foundation, 48 5
A. Geurts, G. Cost, S. Remy, X. Cui, L. Tesson, C. Usal, S. Ménoret, H. Jacob, I. Anegon, R. Buelow (2010)
Generation of gene-specific mutated rats using zinc-finger nucleases.Methods in molecular biology, 597
L. Dahl, M. Heine, L. Tassinari (1962)
EFFECTS OF CHRONIC EXCESS SALT INGESTIONThe Journal of Experimental Medicine, 115
AE Declèves, Z Zolkipli, J Satriano, L Wang, T Nakayama, M Rogac, TP Le, JL Nortier, MG Farquhar, RK Naviaux, K Sharma (2014)
Regulation of lipid accumulation by AMP-activated kinase in high fat diet-induced kidney injury, 85
(2016)
Dual A 1 / A 2 B Receptor Blockade Improves Cardiac and Renal Outcomes in a Rat Model of Heart Failure with Preserved Ejection Fraction
M. McCaleb, J. Sredy (1992)
Metabolic abnormalities of the hyperglycemic obese Zucker rat.Metabolism: clinical and experimental, 41 5
Zhencheng Yan, Yinxing Ni, Peijian Wang, Jian Chen, Hong-bo He, Jing Sun, T. Cao, Jing Chen, Zhigang Zhao, Zhidan Luo, Lina Chen, Daoyan Liu, Zhiming Zhu (2013)
Peroxisome proliferator‐activated receptor delta protects against obesity‐related glomerulopathy through the P38 MAPK pathwayObesity, 21
Chunhua Jin, Sean O'Boyle, Daniel Kleven, Jennifer Pollock, D. Pollock, J. White (2014)
Antihypertensive and anti‐inflammatory actions of combined azilsartan and chlorthalidone in Dahl salt‐sensitive rats on a high‐fat, high‐salt dietClinical and Experimental Pharmacology and Physiology, 41
Andreas Beyer, G. Raffai, Brian Weinberg, K. Fredrich, J. Lombard (2012)
Dahl Salt-Sensitive Rats Are Protected Against Vascular Defects Related to Diet-Induced ObesityHypertension, 60
J. Corsetti, Janet Sparks, Richard Peterson, Robert Smith, Charles Sparks (2000)
Effect of dietary fat on the development of non-insulin dependent diabetes mellitus in obese Zucker diabetic fatty male and female rats.Atherosclerosis, 148 2
K. O'dea, S. Koletsky (1977)
Effect of caloric restriction on basal insulin levels and the in vivo lipogenesis and glycogen synthesis from glucose in the Koletsky obese rat.Metabolism: clinical and experimental, 26 7
N. Vaziri, Jakk Wong, M. Pahl, Y. Piceno, Jun Yuan, T. DeSantis, Z. Ni, Tien-Hung Nguyen, G. Andersen (2013)
Chronic kidney disease alters intestinal microbial flora.Kidney international, 83 2
H. Kramer, Anand Saranathan, A. Luke, R. Durazo-Arvizu, G. Cao, S. Hou, R. Cooper (2006)
Increasing body mass index and obesity in the incident ESRD population.Journal of the American Society of Nephrology : JASN, 17 5
Natsumi Matsuura, Chiharu Asano, Kai Nagasawa, S. Ito, Yusuke Sano, Yuji Minagawa, Yuichiro Yamada, Takuya Hattori, Shogo Watanabe, T. Murohara, K. Nagata (2015)
Effects of pioglitazone on cardiac and adipose tissue pathology in rats with metabolic syndrome.International journal of cardiology, 179
Kasi McPherson, Lateia Taylor, Ashley Johnson, S. Didion, A. Geurts, M. Garrett, J. Williams (2016)
Early development of podocyte injury independently of hyperglycemia and elevations in arterial pressure in nondiabetic obese Dahl SS leptin receptor mutant rats.American journal of physiology. Renal physiology, 311 4
Takuya Hattori, Tamayo Murase, M. Ohtake, T. Inoue, H. Tsukamoto, Miwa Takatsu, Yosuke Kato, Katsunori Hashimoto, T. Murohara, K. Nagata (2011)
Characterization of a new animal model of metabolic syndrome: the DahlS.Z-Leprfa/Leprfa ratNutrition & Diabetes, 1
C. Maric, J. Hall (2011)
Obesity, metabolic syndrome and diabetic nephropathy.Contributions to nephrology, 170
N. Yokoi, Masayuki Hoshino, Shihomi Hidaka, Eri Yoshida, Masayuki Beppu, Ritsuko Hoshikawa, K. Sudo, A. Kawada, S. Takagi, S. Seino (2013)
A Novel Rat Model of Type 2 Diabetes: The Zucker Fatty Diabetes Mellitus ZFDM RatJournal of Diabetes Research, 2013
S. Paulsen, N. Vrang, L. Larsen, P. Larsen, J. Jelsing (2010)
Stereological assessment of pancreatic beta‐cell mass development in male Zucker Diabetic Fatty (ZDF) rats: correlation with pancreatic beta‐cell functionJournal of Anatomy, 217
H. Chung, J. Lim, M. Kim, S. Shin, Sungjin Chung, B. Choi, H. Kim, Yong‐Soo Kim, C. Park, Y. Chang (2012)
High-fat diet-induced renal cell apoptosis and oxidative stress in spontaneously hypertensive rat are ameliorated by fenofibrate through the PPARα-FoxO3a-PGC-1α pathway.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 27 6
F. Mauvais-Jarvis (2015)
Sex differences in metabolic homeostasis, diabetes, and obesityBiology of Sex Differences, 6
A. Nagae, M. Fujita, H. Kawarazaki, H. Matsui, K. Ando, T. Fujita (2009)
Effect of High Fat Loading in Dahl Salt-Sensitive RatsClinical and Experimental Hypertension, 31
S. Tofovic, H. Kusaka, C. Kost, S. Bastacky (2000)
RENAL FUNCTION AND STRUCTURE IN DIABETIC, HYPERTENSIVE, OBESE ZDFxSHHF-HYBRID RATSRenal Failure, 22
Youfa Wang, Xiaoli Chen, M. Klag, B. Caballero (2006)
Epidemic of childhood obesity: implications for kidney disease.Advances in chronic kidney disease, 13 4
A. Ramezani, D. Raj (2014)
The gut microbiome, kidney disease, and targeted interventions.Journal of the American Society of Nephrology : JASN, 25 4
O. Michaelis, K. Ellwood, J. Judge, N. Schoene, C. Hansen (1984)
Effect of dietary sucrose on the SHR/N-corpulent rat: a new model for insulin-independent diabetes.The American journal of clinical nutrition, 39 4
Xue Cai, C. Lister, Robin Buckingham, L. Pickavance, John Wilding, J. Arch, Shelagh Wilson, G. Williams (2000)
Down-regulation of orexin gene expression by severe obesity in the rats: studies in Zucker fatty and zucker diabetic fatty rats and effects of rosiglitazone.Brain research. Molecular brain research, 77 1
A. Elmarakby, J. Imig (2009)
Obesity is the major contributor to vascular dysfunction and inflammation in high-fat diet hypertensive rats.Clinical science, 118 4
M. Kanauchi, K. Kanauchi, K. Kimura, Tomoko Inoue, Yoshihiko Saito (2006)
Associations of chronic kidney disease with the metabolic syndrome in non-diabetic elderly.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 21 12
M. Praga, E. Hernández, J. Herrero, E. Morales, Y. Revilla, R. Díaz‐González, J. Rodicio (2000)
Influence of obesity on the appearance of proteinuria and renal insufficiency after unilateral nephrectomy.Kidney international, 58 5
D. Linz, M. Hohl, Jonathan Schütze, F. Mahfoud, T. Speer, B. Linz, T. Hübschle, H. Juretschke, R. Dechend, J. Geisel, H. Rütten, M. Böhm (2015)
Progression of kidney injury and cardiac remodeling in obese spontaneously hypertensive rats: the role of renal sympathetic innervation.American journal of hypertension, 28 2
G. Bryce, Patricia Johnson, Ann Sullivan, Judith Stern (1977)
Insulin and Glucagon: Plasma Levels and Pancreatic Release in the Genetically Obese Zucker RatHormone and Metabolic Research, 9
Manabu Ogura, M. Urabe, T. Akimoto, Akira Onishi, C. Ito, Takayuki Ito, Tomonori Tsukahara, Hiroaki Mizukami, A. Kume, S. Muto, Eiji Kusano, Keiya Ozawa (2011)
Interleukin-10 expression induced by adeno-associated virus vector suppresses proteinuria in Zucker obese ratsGene Therapy, 19
AnookhMohanan, A. Dubey, Vikrant Jagtap, A. Mandhare, Ramesh Gupta, V. Chauthaiwale, C. Dutt (2014)
TRC 120038 , a Novel Dual AT 1 / ET A Receptor Blocker for Control of Hypertension , Diabetic Nephropathy , and Cardiomyopathy in ob-ZSF 1 Rats
Miwa Takatsu, Chieko Nakashima, Keiji Takahashi, Tamayo Murase, Takuya Hattori, Hiromi Ito, T. Murohara, K. Nagata (2013)
Calorie Restriction Attenuates Cardiac Remodeling and Diastolic Dysfunction in a Rat Model of Metabolic SyndromeHypertension, 62
B. Jose, S. Ford, P. Super, G. Thomas, I. Dasgupta, S. Taheri (2013)
The Effect of Biliopancreatic Diversion Surgery on Renal Function—a Retrospective StudyObesity Surgery, 23
S. Khan, M. Sattar, N. Abdullah, H. Rathore, A. Ahmad, M. Abdulla, E. Johns (2017)
Improvement in baroreflex control of renal sympathetic nerve activity in obese Sprague Dawley rats following immunosuppressionActa Physiologica, 221
V. Vallon, S. Thomson (2017)
Targeting renal glucose reabsorption to treat hyperglycaemia: the pleiotropic effects of SGLT2 inhibitionDiabetologia, 60
J. Ruiz-Tovar, L. Giner, Felipe Sarro-Sobrin, Maria Alsina, M. Marco, L. Craver (2015)
Laparoscopic Sleeve Gastrectomy Prevents the Deterioration of Renal Function in Morbidly Obese Patients Over 40 YearsObesity Surgery, 25
Chunhua Jin, Yejoo Jeon, Daniel Kleven, J. Pollock, John White, D. Pollock (2014)
Combined Endothelin A Blockade and Chlorthalidone Treatment in a Rat Model of Metabolic SyndromeThe Journal of Pharmacology and Experimental Therapeutics, 351
A. Dobrian, Michael Davies, R. Prewitt, T. Lauterio (2000)
Development of hypertension in a rat model of diet-induced obesity.Hypertension, 35 4
Ian Bloor, S. Sebert, R. Mahajan, M. Symonds (2012)
The Influence of Sex on Early Stage Markers of Kidney Dysfunction in Response to Juvenile ObesityHypertension, 60
Jesus Dominguez, Pengfei Wu, John Hawes, M. Deeg, J. Walsh, S. Packer, Miki Nagase, Constance Temm, E. Goss, Richard Peterson (2006)
Renal injury: similarities and differences in male and female rats with the metabolic syndrome.Kidney international, 69 11
B. Clause (1998)
The Wistar Institute Archives: rats (not mice) and history.The Mendel newsletter; archival resources for the history of genetics & allied sciences, 7
A. Friedman, S. Moe, W. Fadel, M. Inman, S. Mattar, Z. Shihabi, S. Quinney (2013)
Predicting the Glomerular Filtration Rate in Bariatric Surgery PatientsAmerican Journal of Nephrology, 39
Yongli Zhao, Guohua Li, Yuchuan Wang, Zheng-juan Liu (2018)
Alteration of Connexin43 expression in a rat model of obesity-related glomerulopathy.Experimental and molecular pathology, 104 1
J. Friedman, T. Ishizuka, Shan Liu, C. Farrell, D. Bedol, R. Koletsky, H. Kaung, P. Ernsberger (1997)
Reduced insulin receptor signaling in the obese spontaneously hypertensive Koletsky rat.American journal of physiology. Endocrinology and metabolism, 273 5
Nuttawud Chueakula, Krit Jaikumkao, Phatchawan Arjinajarn, A. Pongchaidecha, V. Chatsudthipong, N. Chattipakorn, A. Lungkaphin (2018)
Diacerein alleviates kidney injury through attenuating inflammation and oxidative stress in obese insulin‐resistant ratsFree Radical Biology and Medicine, 115
S. Koletsky (1973)
Obese spontaneously hypertensive rats--a model for study of atherosclerosis.Experimental and molecular pathology, 19 1
F. Spradley, Carmen Miguel, J. Hobbs, D. Pollock, J. Pollock (2013)
Mycophenolate mofetil prevents high-fat diet–induced hypertension and renal glomerular injury in Dahl SS ratsPhysiological Reports, 1
S. Knight, J. Quigley, Jianghe Yuan, Siddhartha Roy, A. Elmarakby, J. Imig (2008)
Endothelial Dysfunction and the Development of Renal Injury in Spontaneously Hypertensive Rats Fed a High-Fat DietHypertension, 51
S. Hoshi, Y. Shu, Fusayo Yoshida, T. Inagaki, J. Sonoda, Teruo Watanabe, K. Nomoto, M. Nagata (2002)
Podocyte Injury Promotes Progressive Nephropathy in Zucker Diabetic Fatty RatsLaboratory Investigation, 82
Youfa Wang, Xiaoli Chen, Y. Song, B. Caballero, L. Cheskin (2008)
Association between obesity and kidney disease: a systematic review and meta-analysis.Kidney international, 73 1
S. Khan, Munavvar Sattar, N. Abdullah, H. Rathore, M. Abdulla, Ashfaq Ahmad, E. Johns (2015)
Obesity depresses baroreflex control of renal sympathetic nerve activity and heart rate in Sprague Dawley rats: role of the renal innervationActa Physiologica, 214
P. Poirier, Thomas Giles, George Bray, Yuling Hong, Judith Stern, F. Pi-Sunyer, Robert Eckel (2006)
Obesity and Cardiovascular Disease: Pathophysiology, Evaluation, and Effect of Weight Loss: An Update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Disease From the Obesity Committee of the Council on Nutrition, Physical Activity, and MetabolismCirculation, 113
Paul Huang (2009)
A comprehensive definition for metabolic syndromeDisease Models & Mechanisms, 2
(2009)
MichalkF324 RENAL DISEASE IN OBESE RAT MODELS AJP-Renal Physiol
M. Hennes, S. Mccune, E. Shrago, A. Kissebah (1990)
Synergistic Effects of Male Sex and Obesity on Hepatic Insulin Dynamics in SHR/Mcc-cp RatDiabetes, 39
Johanna Kuhlmann, C. Neumann‐Haefelin, Ulrich Belz, Jü Kalisch, H. Juretschke, Marion Stein, Elke Kleinschmidt, W. Kramer, A. Herling, N.-H
Intramyocellular Lipid and Insulin Resistance a Longitudinal in Vivo H-spectroscopic Study in Zucker Diabetic Fatty Rats
P. Turnbaugh, R. Ley, M. Mahowald, V. Magrini, E. Mardis, J. Gordon (2006)
An obesity-associated gut microbiome with increased capacity for energy harvestNature, 444
T. Imam, Heidi Fischer, Bocheng Jing, R. Burchette, Shayna Henry, S. Derose, K. Coleman (2017)
Estimated GFR Before and After Bariatric Surgery in CKD.American journal of kidney diseases : the official journal of the National Kidney Foundation, 69 3
A. Chagnac, T. Weinstein, A. Korzets, E. Ramadan, J. Hirsch, U. Gafter (2000)
Glomerular hemodynamics in severe obesity.American journal of physiology. Renal physiology, 278 5
R. Danda, N. Habiba, Hernan Rincon-Choles, B. Bhandari, J. Barnes, H. Abboud, P. Pergola (2005)
Kidney involvement in a nongenetic rat model of type 2 diabetes.Kidney international, 68 6
M. Navarro-Díaz, A. Serra, R. Romero, J. Bonet, Beatriu Bayés, M. Homs, N. Pérez, J. Bonal (2006)
Effect of drastic weight loss after bariatric surgery on renal parameters in extremely obese patients: long-term follow-up.Journal of the American Society of Nephrology : JASN, 17 12 Suppl 3
H. Yanagihara, K. Ushijima, Y. Arakawa, K. Aizawa, A. Fujimura (2016)
Effects of telmisartan and olmesartan on insulin sensitivity and renal function in spontaneously hypertensive rats fed a high fat diet.Journal of pharmacological sciences, 131 3
Emmanuel Cosson, Emmanuel Cosson, Paul Valensi, Dominique Laude, Didier Mesangeau, Hubert Dabiré (2009)
Arterial stiffness and the autonomic nervous system during the development of Zucker diabetic fatty rats.Diabetes & metabolism, 35 5
M. Kurella, J. Lo, G. Chertow (2005)
Metabolic syndrome and the risk for chronic kidney disease among nondiabetic adults.Journal of the American Society of Nephrology : JASN, 16 7
K. Takaya, Y. Ogawa, J. Hiraoka, K. Hosoda, Y. Yamori, K. Nakao, R. Koletsky (1996)
Nonsense mutation of leptin receptor in the obese spontaneously hypertensive Koletsky ratNature Genetics, 14
A. Polichnowski, Hector Licea-Vargas, M. Picken, Jianrui Long, Rashmi Bisla, G. Williamson, A. Bidani, K. Griffin (2015)
Glomerulosclerosis in the diet-induced obesity model correlates with sensitivity to nitric oxide inhibition but not glomerular hyperfiltration or hypertrophy.American journal of physiology. Renal physiology, 309 9
T. Srivastava (2006)
Nondiabetic consequences of obesity on kidneyPediatric Nephrology, 21
D. Mostafa, Rasha Nasra, N. Zahran, M. Ghoneim (2016)
Pleiotropic protective effects of Vitamin D against high fat diet-induced metabolic syndrome in rats: One for all.European journal of pharmacology, 792
F. Bäckhed, J. Manchester, C. Semenkovich, J. Gordon (2007)
Mechanisms underlying the resistance to diet-induced obesity in germ-free miceProceedings of the National Academy of Sciences, 104
M. Gades, M. Gades, H. Goor, H. Goor, G. Kaysen, G. Kaysen, P. Johnson, P. Johnson, B. Horwitz, B. Horwitz, J. Stern, J. Stern (1999)
Brief periods of hyperphagia cause renal injury in the obese Zucker rat.Kidney international, 56 5
S. Tofovic, E. Salah, G. Smits, E. Whalley, B. Ticho, A. Deykin, E. Jackson (2016)
Dual A1/A2B Receptor Blockade Improves Cardiac and Renal Outcomes in a Rat Model of Heart Failure with Preserved Ejection FractionThe Journal of Pharmacology and Experimental Therapeutics, 356
J. Perucca, N. Bouby, P. Valeix, L. Bankir (2007)
Sex difference in urine concentration across differing ages, sodium intake, and level of kidney disease.American journal of physiology. Regulatory, integrative and comparative physiology, 292 2
J. Spence (2013)
Faculty Opinions recommendation of Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report.
Qin Zhang, K. Davis, D. Hoffmann, V. Vaidya, Ronald Brown, P. Goering (2014)
Urinary biomarkers track the progression of nephropathy in hypertensive and obese rats.Biomarkers in medicine, 8 1
Jiao He, G. Yuan, Fangxiao Cheng, Junqing Zhang, Xiaohui Guo (2017)
Mast Cell and M1 Macrophage Infiltration and Local Pro-Inflammatory Factors Were Attenuated with Incretin-Based Therapies in Obesity-Related GlomerulopathyMetabolic Syndrome and Related Disorders, 15
E. Ejerblad, C. Fored, P. Lindblad, J. Fryzek, J. Mclaughlin, O. Nyrén (2006)
Obesity and risk for chronic renal failure.Journal of the American Society of Nephrology : JASN, 17 6
A. Chagnac, T. Weinstein, M. Herman, J. Hirsh, U. Gafter, Y. Ori (2003)
The effects of weight loss on renal function in patients with severe obesity.Journal of the American Society of Nephrology : JASN, 14 6
LK Dahl, M Heine, L Tassinari (1962)
Effects of chronia excess salt ingestion. Evidence that genetic factors play an important role in susceptibility to experimental hypertension, 115
A. Dobrian, M. Davies, S. Schriver, T. Lauterio, R. Prewitt (2001)
Oxidative Stress in a Rat Model of Obesity-Induced HypertensionHypertension: Journal of the American Heart Association, 37
J. Hall, J. Henegar, T. Dwyer, Jiankang Liu, A. Silva, J. Kuo, Lakshmi Tallam (2004)
Is obesity a major cause of chronic kidney disease?Advances in renal replacement therapy, 11 1
Carine Boustany-Kari, P. Harrison, Hongxing Chen, Kathleen Lincoln, H. Qian, Holly Clifford, Hong Wang, Xiaomei Zhang, K. Gueneva-Boucheva, T. Bosanac, D. Wong, R. Fryer, J. Richman, Christopher Sarko, S. Pullen (2016)
A Soluble Guanylate Cyclase Activator Inhibits the Progression of Diabetic Nephropathy in the ZSF1 RatThe Journal of Pharmacology and Experimental Therapeutics, 356
Anne-Émilie Declèves, Z. Zolkipli, J. Satriano, Lin Wang, T. Nakayama, M. Rogac, Thuy Le, J. Nortier, M. Farquhar, R. Naviaux, K. Sharma (2014)
Regulation of lipid accumulation by AMP-activated kinase [corrected] in high fat diet-induced kidney injury.Kidney international, 85 3
M. Praga (2002)
Obesity--a neglected culprit in renal disease.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 17 7
Diabetes and hypertension are the major causes of chronic kidney disease (CKD). Epidemiological studies within the last few decades have revealed that obesity-associated renal disease is an emerging epidemic and that the increasing prevalence of obesity parallels the increased rate of CKD. This has led to the inclusion of obesity as an independent risk factor for CKD. A major complication when studying the relationship between obesity and renal injury is that cardiovascular and metabolic disorders that may result from obesity including hyperglycemia, hypertension, and dyslipidemia, or the cluster of these disorders [defined as the metabolic syndrome, (MetS)] also contribute to the development and progression of renal disease. The associations between hyperglycemia and hypertension with renal disease have been reported extensively in patients suffering from obesity. Currently, there are several obese rodent models (high-fat diet-induced obesity and leptin signaling dysfunction) that exhibit characteristics of MetS. However, the available obese rodent models currently have not been used to investigate the impact of obesity alone on the development of renal injury before hypertension and/or hyperglycemia. Therefore, the aim of this review is to describe the incidence and severity of renal disease in these rodent models of obesity and determine which models are suitable to study the independent effects obesity on the development and progression of renal disease.
American Journal of Physiology-Renal Physiology – The American Physiological Society
Published: Feb 1, 2019
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.