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RL Riley, JB. West (1980)
Development of the three-compartment model for dealing with uneven distribution
RL Riley, A Cournand (1949)
Ideal alveolar air and the analysis of ventilation-perfusion relationships in the lungs, 1
L. Farhi (1967)
Elimination of inert gas by the lung.Respiration physiology, 3 1
Under the three-compartment model of ventilation-perfusion (VA/Q) scatter, Bohr-Enghoff calculation of alveolar deadspace fraction (VDA/VA) uses arterial CO2 partial pressure measurement as an approximation of "ideal" alveolar CO2(ideal PACO2). However, this simplistic model suffers from several inconsistencies. Modelling of realistic physiological distributions of VA and Q instead suggests an alternative concept of "ideal" alveolar gas at the VA/Q ratio where uptake or elimination rate of a gas is maximal. The alveolar-capillary partial pressure at this "modal" point equals the mean of expired alveolar and arterial partial pressures, regardless of VA/Q scatter severity or overall VA/Q. For example, modal ideal PACO2 can be estimated from Estimated modal ideal PACO2 = (PACO2+PaCO2)/2 Using a multicompartment computer model of log normal distributions of VA and Q, agreement of this estimate with the modal ideal PACO2 located at the VA/Q ratio of maximal compartmental VCO2 was assessed across a wide range of severity of VA/Q scatter and overall VA/Q ratio. Agreement of VDA/VA for CO2 from the Bohr equation using modal idealPCO2 with that using the estimated value was also assessed. Estimated modal ideal PACO2 agreed closely with modal ideal PACO2, intraclass correlation (ICC) > 99.9%. There was no significant difference between VDA/VACO2 using either value for ideal PACO2. Modal ideal PACO2 reflects a physiologically realistic concept of ideal alveolar gas where there is maximal gas exchange effectiveness in a physiological distribution of VA/Q, which is generalizable to any inert gas, and is practical to estimate from arterial and end-expired CO2 partial pressures.
Journal of Applied Physiology – The American Physiological Society
Published: Dec 1, 2021
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