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Am J Physiol Renal Physiol 320: F1028–F1029, 2021. First published May 3, 2021; doi:10.1152/ajprenal.00160.2021 EDITORIAL 1,2 David Sheikh-Hamad Division of Nephrology and Selzman Institute for Kidney Health, Department of Medicine, Baylor College of Medicine, Houston, Texas and Center for Translational Research on Inflammatory Diseases, Michael E. Debakey Veterans Affairs Medical Center, Houston, Texas Lactate, an end product of glycolysis, is produced and used LDHB proteins decrease globally in models of chronic kidney continuously in many cells under both aerobic and anaerobic disease. In vitro studies in proximal tubule cells have shown conditions, as a result of substrate supply and equilibrium dy- increased LDHA following hypoxia without a change in LDHB. namics (1). The metabolism of lactate is mediated by lactate The authors’ data suggest that proximal tubules are lactate pro- dehydrogenase (LDH), which is highly expressed in the kid- ducers, whereas distal nephron segments are lactate consum- ney; the location and identity of kidney LDH isoforms have ers. In essence, lactate may be shuttled from the proximal not been clearly defined. There are four LDH genes and five nephron to the distal nephron as fuel or for signaling, a plausi- LDH isoenzymes: LDH-1–LDH-5 (2). Kidney LDH is a tetramer
American Journal of Physiology-Renal Physiology – The American Physiological Society
Published: Jun 1, 2021
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