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- ISSN
- 1931-857x
- eISSN
- 1522-1466
- DOI
- 10.1152/ajprenal.00045.2020
- Publisher site
- See Article on Publisher Site
Abstract
The mechanisms underlying hypertension are multi-faceted and incompletely understood. New evidence suggests that the G protein-coupled estrogen receptor 1 (GPER1) mediates protective actions within the cardiovascular and renal systems. This minireview focuses on recent advancements in our understanding of the vascular, renal, and cardiac GPER1-mediated mechanisms that influence blood pressure regulation. We emphasize clinical and basic evidence that suggests GPER1 as a novel target to aid therapeutic strategies for hypertension. Furthermore, we discuss current controversies and challenges facing GPER1-related research.
Journal
American Journal of Physiology-Renal Physiology – The American Physiological Society
Published: Oct 1, 2020