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N. Kimura, M. Okuda, K. Inui (2005)
Metformin Transport by Renal Basolateral Organic Cation Transporter hOCT2Pharmaceutical Research, 22
R. Mccance, E. Widdowson (1960)
The acid—base relationships of the foetal fluids of the pigThe Journal of Physiology, 151
D. Sebinger, Mathieu Unbekandt, Veronika Ganeva, A. Ofenbauer, C. Werner, J. Davies (2010)
A Novel, Low-Volume Method for Organ Culture of Embryonic Kidneys That Allows Development of Cortico-Medullary Anatomical OrganizationPLoS ONE, 5
Tomoya Yasujima, Kin-ya Ohta, Katsuhisa Inoue, M. Ishimaru, H. Yuasa (2010)
Evaluation of 4′,6-Diamidino-2-phenylindole as a Fluorescent Probe Substrate for Rapid Assays of the Functionality of Human Multidrug and Toxin Extrusion ProteinsDrug Metabolism and Disposition, 38
F. Staud, L. Červený, Davoud Ahmadimoghaddam, M. Ceckova (2013)
Multidrug and toxin extrusion proteins (MATE/SLC47); role in pharmacokinetics.The international journal of biochemistry & cell biology, 45 9
Daniel Terreros, EM Klaustied (1991)
Renal ontogeny: epithelial transport in the mammalian mesonephric proximal tubule.Annals of clinical and laboratory science, 21 3
Andrew Lickteig, Xingguo Cheng, Lisa Augustine, C. Klaassen, N. Cherrington (2008)
Tissue distribution, ontogeny and induction of the transporters Multidrug and toxin extrusion (MATE) 1 and MATE2 mRNA expression levels in mice.Life sciences, 83 1-2
Yu K
Interaction of Human Organic Anion Transporters 2 and 4 with Organic Anion Transport Inhibitors Experimental Procedures
Harold Moreno-Ortíz, C. Esteban-Pérez, Wael Badran, M. Kent-First (2009)
Isolation and derivation of mouse embryonic germinal cells.Journal of visualized experiments : JoVE, 32
M. Stanier (1960)
The function of the mammalian mesonephrosThe Journal of Physiology, 151
H. Baert (2009)
Werkplekcondities lerend gebruikenDevelopment, 5
Sumito Ito, H. Kusuhara, Miyu Yokochi, Junko Toyoshima, Katsuhisa Inoue, H. Yuasa, Y. Sugiyama (2012)
Competitive Inhibition of the Luminal Efflux by Multidrug and Toxin Extrusions, but Not Basolateral Uptake by Organic Cation Transporter 2, Is the Likely Mechanism Underlying the Pharmacokinetic Drug-Drug Interactions Caused by Cimetidine in the KidneyJournal of Pharmacology and Experimental Therapeutics, 340
K. Tiedemann, L. Welling, Pat Basto (1987)
Structural and functional comparison of mesonephric and metanephric proximal tubulesPediatric Nephrology, 1
G. Youngblood, D. Sweet (2004)
Identification and functional assessment of the novel murine organic anion transporter Oat5 (Slc22a19) expressed in kidney.American journal of physiology. Renal physiology, 287 2
J. Dickerson, R. Mccance (1957)
The Composition and Origin of the Allantoic Fluid in the RabbitDevelopment, 5
J. Jonker, E. Wagenaar, S. Eijl, A. Schinkel (2003)
Deficiency in the Organic Cation Transporters 1 and 2 (Oct1/Oct2 [Slc22a1/Slc22a2]) in Mice Abolishes Renal Secretion of Organic CationsMolecular and Cellular Biology, 23
D. Keppler (2011)
Multidrug resistance proteins (MRPs, ABCCs): importance for pathophysiology and drug therapy.Handbook of experimental pharmacology, 201
Masahiro Okuda, H. Saito, Y. Urakami, Mikihisa Takano, K. Inui (1996)
cDNA cloning and functional expression of a novel rat kidney organic cation transporter, OCT2.Biochemical and biophysical research communications, 224 2
L. Saxén, H. Sariola (1987)
Early organogenesis of the kidneyPediatric Nephrology, 1
J. Davies, J. Routh (1957)
Composition of the foetal fluids of the rabbit.Development, 5
R. Wang, C. Kuo, L. Lien, E. Lien (2003)
Structure–activity relationship: analyses of p‐glycoprotein substrates and inhibitorsJournal of Clinical Pharmacy and Therapeutics, 28
(1937)
The correlation of structure and function in the developing mesonephros and metanephros
J. Jacobsson, T. Haitina, J. Lindblom, R. Fredriksson (2007)
Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family.Genomics, 90 5
Y. Shu, Carlo Bello, L. Mangravite, B. Feng, K. Giacomini (2001)
Functional characteristics and steroid hormone-mediated regulation of an organic cation transporter in Madin-Darby canine kidney cells.The Journal of pharmacology and experimental therapeutics, 299 1
N. Anzai, P. Jutabha, A. Enomoto, H. Yokoyama, H. Nonoguchi, Taku Hirata, K. Shiraya, Xin He, S. Cha, M. Takeda, Hiroki Miyazaki, Takeshi Sakata, K. Tomita, T. Igarashi, Y. Kanai, H. Endou (2005)
Functional Characterization of Rat Organic Anion Transporter 5 (Slc22a19) at the Apical Membrane of Renal Proximal TubulesJournal of Pharmacology and Experimental Therapeutics, 315
G. Ciarimboli, D. Deuster, A. Knief, M. Sperling, Michael Holtkamp, B. Edemir, H. Pavenstädt, C. Lanvers-Kaminsky, A. Zehnhoff-Dinnesen, A. Schinkel, H. Koepsell, H. Jürgens, E. Schlatter (2010)
Organic cation transporter 2 mediates cisplatin-induced oto- and nephrotoxicity and is a target for protective interventions.The American journal of pathology, 176 3
K. Sainio, A. Raatikainen-Ahokas (1999)
Mesonephric kidney--a stem cell factory?The International journal of developmental biology, 43 5
Z. Ni, Z. Bikádi, M. Rosenberg, Qingcheng Mao (2010)
Structure and function of the human breast cancer resistance protein (BCRP/ABCG2).Current drug metabolism, 11 7
B. Monien, C. Müller, N. Bakhiya, C. Donath, H. Frank, A. Seidel, H. Glatt (2009)
Probenecid, an inhibitor of transmembrane organic anion transporters, alters tissue distribution of DNA adducts in 1-hydroxymethylpyrene-treated rats.Toxicology, 262 1
A Enomoto, M Takeda, M Shimoda, S Narikawa, Y Kobayashi, Y Kobayashi, T Yamamoto, T Sekine, SH Cha, T Niwa, H Endou (2002)
Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors, 301
M. Roth, A. Obaidat, B. Hagenbuch (2012)
OATPs, OATs and OCTs: the organic anion and cation transporters of the SLCO and SLC22A gene superfamiliesBritish Journal of Pharmacology, 165
Melanie Lawrence, C-Hong Chang, J. Davies (2015)
Transport of organic anions and cations in murine embryonic kidney development and in serially-reaggregated engineered kidneysScientific Reports, 5
The mesonephros of mammals is a transient renal structure that contributes to various aspects of mammalian fetal development, including the male reproductive system, hematopoietic stem cells, and vascular endothelial cells. The mesonephros develops from the intermediate mesoderm and forms tubules that are segmented in a similar way to the nephrons of the permanent kidney (but lacking loops of Henle). Early studies have suggested that the mesonephros in marsupials and some placental mammals may perform an excretory function, but these studies have not directly shown active transport of organic anions and cations. Excretory function in the rodent mesonephros has not been investigated. Functional characterization of the earliest stages of mammalian renal development is important for our understanding of congenital disease and may help to inform the growing field of renal tissue engineering. Here, we use live uptake and efflux assays in vitro to show that the murine mesonephros is able to transport organic anions and cations through specific transporters from early in its development. Transcript analysis suggests that there are subtle differences between the transporters involved in uptake and efflux by the murine permanent metanephric tubules and by the mesonephric tubules. These data suggest that the mammalian mesonephros can provide an excretory function for the early developing embryo, in addition to the excretory function provided by the placenta.
American Journal of Physiology-Renal Physiology – The American Physiological Society
Published: Jul 1, 2018
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