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N Vij, P Chandramani-Shivalingappa, C Van Westphal, R Hole, M Bodas (2018)
Cigarette smoke-induced autophagy impairment accelerates lung aging, COPD-emphysema exacerbations and pathogenesis, 314
V Deretic, T Saitoh, S Akira (2013)
Autophagy in infection, inflammation and immunity, 13
DM Ferriero (2004)
Neonatal brain injury, 351
J Lawrence, D Xiao, Q Xue, M Rejali, S Yang, L Zhang (2008)
Prenatal nicotine exposure increases heart susceptibility to ischemia/reperfusion injury in adult offspring, 324
Y Li, AM Song, Y Fu, A Walayat, M Yang, J Jian, B Liu, L Xia, L Zhang, D Xiao (2019)
Perinatal nicotine exposure alters Akt/GSK-3β/mTOR/autophagy signaling, leading to development of hypoxic-ischemic-sensitive phenotype in rat neonatal brain, 317
L Peng, Z Yuan, H Ling, K Fukasawa, K Robertson, N Olashaw, J Koomen, J Chen, WS Lane, E Seto (2011)
SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activities, 31
RC Vannucci, JR Connor, DT Mauger, C Palmer, MB Smith, J Towfighi, SJ Vannucci (1999)
Rat model of perinatal hypoxic-ischemic brain damage, 55
T Nguyen, GE Li, H Chen, CG Cranfield, KC McGrath, CA Gorrie (2018)
Maternal e-cigarette exposure results in cognitive and epigenetic alterations in offspring in a mouse model, 31
BR Joubert, SE Håberg, RM Nilsen, X Wang, SE Vollset, SK Murphy, Z Huang, C Hoyo, Ø Midttun, LA Cupul-Uicab, PM Ueland, MC Wu, W Nystad, DA Bell, SD Peddada, SJ London (2012)
450K epigenome-wide scan identifies differential DNA methylation in newborns related to maternal smoking during pregnancy, 120
JY Yager, S Ashwal (2009)
Animal models of perinatal hypoxic–ischemic brain damage, 40
RM Greene, MM Pisano (2019)
Developmental toxicity of e-cigarette aerosols, 111
JB Dwyer, SC McQuown, FM Leslie (2009)
The dynamic effects of nicotine on the developing brain, 122
M Bodas, C Van Westphal, R Carpenter-Thompson, DK Mohanty, N Vij (2016)
Nicotine exposure induces bronchial epithelial cell apoptosis and senescence via ROS mediated autophagy-impairment, 97
L Galluzzi, JM Bravo-San Pedro, K Blomgren, G Kroemer (2016)
Autophagy in acute brain injury, 17
MR Orzabal, ER Lunde-Young, JI Ramirez, SYF Howe, VD Naik, J Lee, CL Heaps, DW Threadgill, J Ramadoss (2019)
Chronic exposure to e-cig aerosols during early development causes vascular dysfunction and offspring growth deficits, 207
D Sundrani, A Narang, S Mehendale, S Joshi, P Chavan-Gautam (2017)
Investigating the expression of MMPs and TIMPs in preterm placenta and role of CpG methylation in regulating MMP-9 expression, 69
Y. Chan, S. Saad, R. Machaalani, B. Oliver, B. Vissel, C. Pollock, N. Jones, Hui Chen (2017)
Maternal Cigarette Smoke Exposure Worsens Neurological Outcomes in Adolescent Offspring with Hypoxic-Ischemic InjuryFrontiers in Molecular Neuroscience, 10
MC Tal, M Sasai, HK Lee, B Yordy, GS Shadel, A Iwasaki (2009)
Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling, 106
D. Xiao, Xiaohui Huang, Shumei Yang, Lubo Zhang (2011)
Antenatal nicotine induces heightened oxidative stress and vascular dysfunction in rat offspringBritish Journal of Pharmacology, 164
NR Bhandari, KD Day, N Payakachat, AM Franks, KR McCain, D Ragland (2018)
Use and risk perception of electronic nicotine delivery systems and tobacco in pregnancy, 28
MJ Zarzuelo, R López-Sepúlveda, M Sánchez, M Romero, M Gómez-Guzmán, Z Ungvary, F Pérez-Vizcaíno, R Jiménez, J Duarte (2013)
SIRT1 inhibits NADPH oxidase activation and protects endothelial function in the rat aorta: implications for vascular aging, 85
MT Verklan (2009)
The chilling details: hypoxic-ischemic encephalopathy, 23
Kurt Meyer, Haitao Zhang, Lubo Zhang (2009)
Direct effect of cocaine on epigenetic regulation of PKCepsilon gene repression in the fetal rat heart.Journal of molecular and cellular cardiology, 47 4
DE Lauterstein, PB Tijerina, K Corbett, BA Oksuz, SS Shen, T Gordon, CB Klein, JT Zelikoff (2016)
Frontal cortex transcriptome analysis of mice exposed to electronic cigarettes during early life stages, 13
Joanna Ruszkiewicz, Ziyan Zhang, F. Gonçalves, Y. Tizabi, J. Zelikoff, M. Aschner (2020)
Neurotoxicity of e-cigarettes.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
G St Helen, C Havel, DA Dempsey, P Jacob, NL Benowitz (2016)
Nicotine delivery, retention and pharmacokinetics from various electronic cigarettes, 111
Q Ma, C Dasgupta, Y Li, NM Bajwa, F Xiong, B Harding, R Hartman, L Zhang (2016)
Inhibition of microRNA-210 provides neuroprotection in hypoxic-ischemic brain injury in neonatal rats, 89
J Espinoza-Derout, KM Hasan, XM Shao, MC Jordan, C Sims, DL Lee, S Sinha, Z Simmons, N Mtume, Y Liu, KP Roos, AP Sinha-Hikim, TC Friedman (2019)
Chronic intermittent electronic cigarette exposure induces cardiac dysfunction and atherosclerosis in apolipoprotein-E knockout mice, 317
Anas Ashour, Hashim Alhussain, U. Rashid, Labiba Abughazzah, I. Gupta, A. Malki, S. Vranić, A. Moustafa (2020)
E-Cigarette Liquid Provokes Significant Embryotoxicity and Inhibits AngiogenesisToxics, 8
H Chen, G Li, YL Chan, T Nguyen, D van Reyk, S Saad, BG Oliver (2018)
Modulation of neural regulators of energy homeostasis, and of inflammation, in the pups of mice exposed to e-cigarettes, 684
J Jian, P Zhang, Y Li, B Liu, Y Zhang, L Zhang, XM Shao, J Zhuang, D Xiao (2020)
Reprogramming of miR-181a/DNA methylation patterns contribute to the maternal nicotine exposure-induced fetal programming of cardiac ischemia-sensitive phenotype in postnatal life, 10
IH Lee, L Cao, R Mostoslavsky, DB Lombard, J Liu, NE Bruns, M Tsokos, FW Alt, T Finkel (2008)
A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy, 105
KA Tekirdag, G Korkmaz, DG Ozturk, R Agami, D Gozuacik (2013)
MIR181A regulates starvation- and rapamycin-induced autophagy through targeting of ATG5, 9
AA Lopez, MM Hiler, EK Soule, CP Ramôa, NV Karaoghlanian, T Lipato, AB Breland, AL Shihadeh, T Eissenberg (2016)
Effects of electronic cigarette liquid nicotine concentration on plasma nicotine and puff topography in tobacco cigarette smokers: a preliminary report, 18
M. Wetendorf, L. Randall, M. Lemma, Sophia Hurr, J. Pawlak, R. Tarran, C. Doerschuk, K. Caron (2019)
E-Cigarette Exposure Delays Implantation and Causes Reduced Weight Gain in Female Offspring Exposed In UteroJournal of the Endocrine Society, 3
H Chen, G Li, YL Chan, DG Chapman, S Sukjamnong, T Nguyen, T Annissa, KC McGrath, P Sharma, BG Oliver (2018)
Maternal e-cigarette exposure in mice alters DNA methylation and lung cytokine expression in offspring, 58
D. Barker, D. Barker (2012)
Sir Richard Doll Lecture. Developmental origins of chronic disease.Public health, 126 3
VF Oliver, M Franchina, AE Jaffe, KE Branham, M Othman, JR Heckenlively, A Swaroop, B Campochiaro, BJ Vote, JE Craig, R Saffery, DA Mackey, J Qian, DJ Zack, AW Hewitt, SL Merbs (2013)
Hypomethylation of the IL17RC promoter in peripheral blood leukocytes is not a hallmark of age-related macular degeneration, 5
FM Menzies, A Fleming, DC Rubinsztein (2015)
Compromised autophagy and neurodegenerative diseases, 16
A Doria, M Gatto, L Punzi (2013)
Autophagy in human health and disease, 368
Yong Li, D. Xiao, Shumei Yang, Lubo Zhang (2013)
Promoter methylation represses AT2R gene and increases brain hypoxic–ischemic injury in neonatal ratsNeurobiology of Disease, 60
Y Li, Q Ma, C Dasgupta, S Halavi, RE Hartman, D Xiao, L Zhang (2017)
Inhibition of DNA methylation in the developing rat brain disrupts sexually dimorphic neurobehavioral phenotypes in adulthood, 54
N. Wagner, Marie Camerota, Cathi Propper (2017)
Prevalence and Perceptions of Electronic Cigarette Use during PregnancyMaternal and Child Health Journal, 21
JR Whittington, PM Simmons, AM Phillips, SK Gammill, R Cen, EF Magann, VM Cardenas (2018)
The use of electronic cigarettes in pregnancy: a review of the literature, 73
YS Hori, A Kuno, R Hosoda, M Tanno, T Miura, K Shimamoto, Y Horio (2011)
Resveratrol ameliorates muscular pathology in the dystrophic mdx mouse, a model for Duchenne muscular dystrophy, 338
V Bahl, S Lin, N Xu, B Davis, YH Wang, P Talbot (2012)
Comparison of electronic cigarette refill fluid cytotoxicity using embryonic and adult models, 34
M Suter, J Ma, A Harris, L Patterson, KA Brown, C Shope, L Showalter, A Abramovici, KM Aagaard-Tillery (2011)
Maternal tobacco use modestly alters correlated epigenome-wide placental DNA methylation and gene expression, 6
Z Chen, L Gong, P Zhang, Y Li, B Liu, L Zhang, J Zhuang, D Xiao (2019)
Epigenetic down-regulation of Sirt 1 via DNA methylation and oxidative stress signaling contributes to the gestational diabetes mellitus-induced fetal programming of heart ischemia-sensitive phenotype in late life, 15
AE Sifat, S Nozohouri, H Villalba, AA Shoyaib, B Vaidya, VT Karamyan, T Abbruscato (2020)
Prenatal electronic cigarette exposure decreases brain glucose utilization and worsens outcome in offspring hypoxic–ischemic brain injury, 153
Y Li, D Xiao, C Dasgupta, F Xiong, W Tong, S Yang, L Zhang (2012)
Perinatal nicotine exposure increases vulnerability of hypoxic-ischemic brain injury in neonatal rats: role of angiotensin II receptors, 43
X Lv, H Jiang, B Li, Q Liang, S Wang, Q Zhao, J Jiao (2014)
The crucial role of Atg5 in cortical neurogenesis during early brain development, 4
S Schmidt (2020)
E-cigarette aerosols and the brain: behavioral and neuroinflammatory changes in prenatally exposed adult mice, 128
P Zhang, Y Li, Y Fu, L Huang, B Liu, L Zhang, XM Shao, D Xiao (2020)
Inhibition of autophagy signaling via 3-methyladenine rescued nicotine-mediated cardiac pathological effects and heart dysfunctions, 16
XM Shao, B Lopez, D Nathan, J Wilson, E Bankole, H Tumoyan, A Munoz, J Espinoza-Derout, KM Hasan, S Chang, C Du, AP Sinha-Hikim, K Lutfy, TC Friedman (2019)
A mouse model for chronic intermittent electronic cigarette exposure exhibits nicotine pharmacokinetics resembling human vapers, 326
BH Han, DM Holtzman (2000)
BDNF protects the neonatal brain from hypoxic-ischemic injury in vivo via the ERK pathway, 20
Maternal e-cigarette (e-cig) exposure is a pressing perinatal health concern. Emerging evidence reveals its potential adverse impacts on brain development in offspring, yet the underlying mechanisms are poorly understood. The present study tested the hypothesis that fetal e-cig exposure induces an aberrant DNA methylation profile in the developing brain, leading to alteration of autophagic flux signaling and programming of a sensitive phenotype to neonatal hypoxic-ischemic encephalopathy (HIE). Pregnant rats were exposed to chronic intermittent e-cig aerosol. Neonates were examined at the age of 9 days old. Maternal e-cig exposure decreased the body weight and brain weight but enhanced the brain-to-body weight ratio in the neonates. E-cig exposure induced a gender-dependent increase in hypoxic-ischemia-induced brain injury in male neonates associated with enhanced reactive oxygen species (ROS) activity. It differentially altered DNA methyltransferase expression and enhanced both global DNA methylation levels and specific CpG methylation at the autophagy-related gene 5 (ATG5) promoter. In addition, maternal e-cig exposure caused downregulations of ATG5, microtubule-associated protein 1 light chain 3β, and sirtuin 1 expression in neonatal brains. Of importance, knockdown of ATG5 in neonatal pups exaggerated neonatal HIE. In conclusion, the present study reveals that maternal e-cig exposure downregulates autophagy-related gene expression via DNA hypermethylation, leading to programming of a hypoxic-ischemic sensitive phenotype in the neonatal brain.
AJP - Regulatory, Integrative and Comparative Physiology – The American Physiological Society
Published: Nov 1, 2021
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